Yogurt beverages as a vehicle to deliver high dose probiotics

酸奶饮料作为提供高剂量益生菌的载体

基本信息

  • 批准号:
    8491751
  • 负责人:
  • 金额:
    $ 31.7万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-09-01 至 2016-03-31
  • 项目状态:
    已结题

项目摘要

Abstract: Probiotics are live microorganisms that, when administered in sufficient amounts, may improve health. Often, probiotics are ingested as supplements in powder, pill or liquid forms, designed specifically for medicinal benefit. Yogurt can be an effective delivery vehicle for probiotics, but generally yogurts available in the United States are not formulated with attention to optimal probiotic strains or dose. Yogurt is also an attractive delivery agent because of its popularity with parents and children, likely improving compliance. We propose to evaluate yogurt formulated with a probiotic strain at a dose that results in recovery in stools. The long-term goal of this project is to demonstrate that a probiotic-containing yogurt beverage can be used successfully as a vehicle for delivering health-enhancing probiotics to children. The specific goals of this study are to determine if a yogurt drink containing Bifidobacterium lactis (Bb-12) at a minimum 1010 colony forming units (CFU)/per serving can prevent antibiotic-associated diarrhea (AAD). We have three specific aims to accomplish these goals. Aim #1: To determine if consumption of a yogurt drink containing a high dose of probiotics decreases the incidence of antibiotic-associated diarrhea in children ages 1-3 taking a penicillin-class antibiotic compared to a matching placebo drink. Aim #2: To evaluate the feasibility of children consuming a drinkable yogurt on a regular daily basis when the children are ill. Aim #3: To determine if the supplemental Bb-12 probiotics survive the gastrointestinal tract and can be recovered from the stools of participants consuming the Bb-12 yogurt drink. This proposal is in direct response to a PA and our Aims are in consort with NCCAM's mission. NCCAM has identified areas of research needing further investigation, stating, "Use of adequately defined products and optimal dosage schedules in studies decreases the risk of failures that might discourage further research into otherwise promising modalities." Therefore, NCCAM recommends studies designed to: 1) determine active ingredients, pharmacology, bioavailability and optimal dosing; 2) identify surrogate markers; and, 3) assess study feasibility. The outcomes of these studies will form the basis for designing larger trials with an enhanced ability to detect a meaningful positive effect of the therapy under study. A readily available yogurt with high dose probiotics has the potential to positively impact the health of children around the world, as yogurt will likely be more appealing to both children and their parents for long term consumption than pharmaceutical-like probiotic preparations.
文摘:

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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DANIEL J MERENSTEIN其他文献

DANIEL J MERENSTEIN的其他文献

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{{ truncateString('DANIEL J MERENSTEIN', 18)}}的其他基金

A Phase II randomized controlled trial to evaluate the role of BB-12 in antibiotic-associated diarrhea and its effects on the gut microbiome
一项 II 期随机对照试验,旨在评估 BB-12 在抗生素相关性腹泻中的作用及其对肠道微生物组的影响
  • 批准号:
    10425501
  • 财政年份:
    2021
  • 资助金额:
    $ 31.7万
  • 项目类别:
Exploratory Pilot Studies to Demonstrate Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics
探索性试点研究展示预防抗生素相关腹泻的机制和益生菌的作用
  • 批准号:
    10480824
  • 财政年份:
    2018
  • 资助金额:
    $ 31.7万
  • 项目类别:
Exploratory Pilot Studies to Demonstrate Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics
探索性试点研究展示预防抗生素相关腹泻的机制和益生菌的作用
  • 批准号:
    10264947
  • 财政年份:
    2018
  • 资助金额:
    $ 31.7万
  • 项目类别:
Exploratory Pilot Studies to Demonstrate Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics
探索性试点研究展示预防抗生素相关腹泻的机制和益生菌的作用
  • 批准号:
    10222939
  • 财政年份:
    2018
  • 资助金额:
    $ 31.7万
  • 项目类别:
A Phase II randomized controlled trial to evaluate the role of BB-12 in antibiotic-associated diarrhea and its effects on the gut microbiome
一项 II 期随机对照试验,旨在评估 BB-12 在抗生素相关性腹泻中的作用及其对肠道微生物组的影响
  • 批准号:
    9296802
  • 财政年份:
    2017
  • 资助金额:
    $ 31.7万
  • 项目类别:
Yogurt beverages as a vehicle to deliver high dose probiotics
酸奶饮料作为提供高剂量益生菌的载体
  • 批准号:
    7314203
  • 财政年份:
    2009
  • 资助金额:
    $ 31.7万
  • 项目类别:
Yogurt beverages as a vehicle to deliver high dose probiotics
酸奶饮料作为提供高剂量益生菌的载体
  • 批准号:
    8440639
  • 财政年份:
    2009
  • 资助金额:
    $ 31.7万
  • 项目类别:
Yogurt beverages as a vehicle to deliver high dose probiotics
酸奶饮料作为提供高剂量益生菌的载体
  • 批准号:
    7937876
  • 财政年份:
    2009
  • 资助金额:
    $ 31.7万
  • 项目类别:
THE DRINK STUDY-DECREASING RATES OF ILLNESSES IN KIDS
饮料研究——降低儿童患病率
  • 批准号:
    7608332
  • 财政年份:
    2006
  • 资助金额:
    $ 31.7万
  • 项目类别:

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