CB1 Receptor Imaging in Anorexia

描述(由申请人提供)：该项目旨在为神经性厌食症患者体重调节相关的适应不良过程提供一个翻译模型，同时也为为这一患者群体开发新的治疗方法奠定基础。我们的建议旨在对两个主要的应激反应系统--内源性大麻素(ECB)系统和糖皮质激素系统的功能提供一个综合的观点，为未来对这些系统测试针对这些患者的特定干预措施的研究奠定基础。这项建议是 一项为期两年的研究涉及N=10名无药物体重的女性(REC)和10名年龄和体重匹配的健康对照组(CONT)，她们参加了一项磁共振成像(MRI)、一项PET研究和激素评估。我们提出了一个模型，在AN中，与体重调节相关的适应不良神经行为反应是由于ECB信号受损和神经内分泌信号不足造成的。) 公共卫生相关性：该项目旨在提供与神经性厌食症患者体重调节相关的适应不良过程的翻译模型，同时也为为这类患者群体开发新的治疗方法奠定基础。我们的建议旨在对两个主要的应激反应系统--内源性大麻素(ECB)系统和糖皮质激素系统的功能提供一个综合的观点，为未来对这些系统测试针对这些患者的特定干预措施的研究奠定基础。这项建议是 一项为期两年的研究涉及N=10名无药物体重的女性(REC)和10名年龄和体重匹配的健康对照组(CONT)，她们参加了一项磁共振成像(MRI)、一项PET研究和激素评估。

DESCRIPTION (provided by applicant): This project aims to provide a translational model of the maladaptive processes associated with weight regulation in anorexia nervosa but in addition to lay the foundation to develop novel treatment developments for this patient population. Our proposal aims to provide an integrative view on the functions of two major stress-response systems, the endocannabinoid (eCB) system and glucocorticoids, which lays the foundation for future studies of these systems testing specific interventions for these patients. This proposal is a 2-year study involving N=10 medication free weight restored women with AN (AN REC) and 10 healthy age and weight matched controls (CONT) to participate in one magnetic resonance imaging (MRI), one PET study, and hormonal assessments. We propose a model that in AN the maladaptive neurobehavioral response related to weight regulation results from impaired eCB signaling and insufficient neuroendocrine signaling. ) PUBLIC HEALTH RELEVANCE: This project aims to provide a translational model of the maladaptive processes associated with weight regulation in anorexia nervosa but in addition to lay the foundation to develop novel treatment developments for this patient population. Our proposal aims to provide an integrative view on the functions of two major stress-response systems, the endocannabinoid (eCB) system and glucocorticoids, which lays the foundation for future studies of these systems testing specific interventions for these patients. This proposal is a 2-year study involving N=10 medication free weight restored women with AN (AN REC) and 10 healthy age and weight matched controls (CONT) to participate in one magnetic resonance imaging (MRI), one PET study, and hormonal assessments.