CB1 Receptor Imaging in Anorexia

描述（由申请人提供）：该项目旨在提供与神经性厌食症体重调节相关的适应不良过程的转化模型，同时为该患者群体开发新型治疗方法奠定基础。我们的建议旨在提供两个主要的压力反应系统，内源性大麻素（eCB）系统和糖皮质激素的功能，这为这些系统的未来研究奠定了基础，测试这些患者的具体干预措施。这项建议是 一项为期2年的研究，涉及N=10名无药物体重恢复的AN女性（AN REC）和10名健康年龄和体重匹配的对照（CONT），参与一项磁共振成像（MRI）、一项PET研究和激素评估。我们提出了一个模型，在AN的适应不良的神经行为反应与体重调节的结果从受损的eCB信号和神经内分泌信号不足。) 公共卫生相关性：该项目旨在提供神经性厌食症中与体重调节相关的适应不良过程的转化模型，同时也为该患者群体开发新的治疗方法奠定基础。我们的建议旨在提供两个主要的压力反应系统，内源性大麻素（eCB）系统和糖皮质激素的功能，这为这些系统的未来研究奠定了基础，测试这些患者的具体干预措施。这项建议是 一项为期2年的研究，涉及N=10名无药物体重恢复的AN女性（AN REC）和10名健康年龄和体重匹配的对照（CONT），参与一项磁共振成像（MRI）、一项PET研究和激素评估。

DESCRIPTION (provided by applicant): This project aims to provide a translational model of the maladaptive processes associated with weight regulation in anorexia nervosa but in addition to lay the foundation to develop novel treatment developments for this patient population. Our proposal aims to provide an integrative view on the functions of two major stress-response systems, the endocannabinoid (eCB) system and glucocorticoids, which lays the foundation for future studies of these systems testing specific interventions for these patients. This proposal is a 2-year study involving N=10 medication free weight restored women with AN (AN REC) and 10 healthy age and weight matched controls (CONT) to participate in one magnetic resonance imaging (MRI), one PET study, and hormonal assessments. We propose a model that in AN the maladaptive neurobehavioral response related to weight regulation results from impaired eCB signaling and insufficient neuroendocrine signaling. ) PUBLIC HEALTH RELEVANCE: This project aims to provide a translational model of the maladaptive processes associated with weight regulation in anorexia nervosa but in addition to lay the foundation to develop novel treatment developments for this patient population. Our proposal aims to provide an integrative view on the functions of two major stress-response systems, the endocannabinoid (eCB) system and glucocorticoids, which lays the foundation for future studies of these systems testing specific interventions for these patients. This proposal is a 2-year study involving N=10 medication free weight restored women with AN (AN REC) and 10 healthy age and weight matched controls (CONT) to participate in one magnetic resonance imaging (MRI), one PET study, and hormonal assessments.