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CB1 Receptor Imaging in Anorexia

厌食症中的 CB1 受体成像

基本信息

批准号：
8302068
负责人：
ALEXANDER NEUMEISTER
金额：
$ 26.33万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-04-01 至 2014-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8302068
关键词：
Adipose tissue Affect Age Anorexia Anorexia Nervosa Anti-Anxiety Agents Anxiety Behavior Behavioral Binding Body Weight Body Weight decreased CNR1 gene Cerebrum Clinical Diet Dietary intake Eating Endocannabinoids Enzymes Estrogens Exhibits Female Food Foundations Fright Functional disorder Future Gender Genetic Genetic Polymorphism Genetic Transcription Glucocorticoids Gonadal Hormones Hormonal Hormones Hospitalization Hydrocortisone Hypothalamic structure Image Individual Intervention Leptin Ligands Magnetic Resonance Imaging Mediating Modeling Neurobiology Neurosecretory Systems Nucleus Accumbens Obsession Opiates Ovarian Patients Peripheral Pharmaceutical Preparations Pituitary Gland Play Positron-Emission Tomography Prevalence Process Production Recruitment Activity Regulation Relapse Reproduction Role Serotonin Severities Sex Characteristics Shapes Signal Transduction Source Starvation Stimulus Stress Stress and Coping Symptoms System Testing Testosterone Therapeutic Weight Weight Gain Woman Work acute traumatic stress disorder anandamide base biological adaptation to stress dehydroepiandrosterone driving behavior energy balance fatty acid amide hydrolase hypercortisolemia inhibitor/antagonist mRNA Expression male meetings men mortality neurobehavioral novel patient population preclinical study radioligand receptor receptor binding receptor density receptor expression response restoration restraint success therapy development weight maintenance

项目摘要

DESCRIPTION (provided by applicant): This project aims to provide a translational model of the maladaptive processes associated with weight regulation in anorexia nervosa but in addition to lay the foundation to develop novel treatment developments for this patient population. Our proposal aims to provide an integrative view on the functions of two major stress-response systems, the endocannabinoid (eCB) system and glucocorticoids, which lays the foundation for future studies of these systems testing specific interventions for these patients. This proposal is a 2-year study involving N=10 medication free weight restored women with AN (AN REC) and 10 healthy age and weight matched controls (CONT) to participate in one magnetic resonance imaging (MRI), one PET study, and hormonal assessments. We propose a model that in AN the maladaptive neurobehavioral response related to weight regulation results from impaired eCB signaling and insufficient neuroendocrine signaling. ) PUBLIC HEALTH RELEVANCE: This project aims to provide a translational model of the maladaptive processes associated with weight regulation in anorexia nervosa but in addition to lay the foundation to develop novel treatment developments for this patient population. Our proposal aims to provide an integrative view on the functions of two major stress-response systems, the endocannabinoid (eCB) system and glucocorticoids, which lays the foundation for future studies of these systems testing specific interventions for these patients. This proposal is a 2-year study involving N=10 medication free weight restored women with AN (AN REC) and 10 healthy age and weight matched controls (CONT) to participate in one magnetic resonance imaging (MRI), one PET study, and hormonal assessments.

描述（由申请人提供）：该项目旨在提供与神经性厌食症体重调节相关的适应不良过程的转化模型，同时为该患者群体开发新型治疗方法奠定基础。我们的建议旨在提供两个主要的压力反应系统，内源性大麻素（eCB）系统和糖皮质激素的功能，这为这些系统的未来研究奠定了基础，测试这些患者的具体干预措施。这项建议是一项为期2年的研究，涉及N=10名无药物体重恢复的AN女性（AN REC）和10名健康年龄和体重匹配的对照（CONT），参与一项磁共振成像（MRI）、一项PET研究和激素评估。我们提出了一个模型，在AN的适应不良的神经行为反应与体重调节的结果从受损的eCB信号和神经内分泌信号不足。) 公共卫生关系：该项目旨在提供神经性厌食症中与体重调节相关的适应不良过程的转化模型，同时也为该患者群体开发新的治疗方法奠定基础。我们的建议旨在提供两个主要的压力反应系统，内源性大麻素（eCB）系统和糖皮质激素的功能，这为这些系统的未来研究奠定了基础，测试这些患者的具体干预措施。这项建议是一项为期2年的研究，涉及N=10名无药物体重恢复的AN女性（AN REC）和10名健康年龄和体重匹配的对照（CONT），参与一项磁共振成像（MRI）、一项PET研究和激素评估。