CB1 Receptor Imaging in Anorexia

描述（由申请人提供）：本项目旨在提供神经性厌食症中与体重调节相关的适应不良过程的翻译模型，同时为开发针对该患者群体的新治疗方案奠定基础。我们的建议旨在提供两个主要的应激反应系统，内源性大麻素（eCB）系统和糖皮质激素功能的综合观点，为这些系统的未来研究奠定基础，为这些患者测试特定的干预措施。这个建议是

DESCRIPTION (provided by applicant): This project aims to provide a translational model of the maladaptive processes associated with weight regulation in anorexia nervosa but in addition to lay the foundation to develop novel treatment developments for this patient population. Our proposal aims to provide an integrative view on the functions of two major stress-response systems, the endocannabinoid (eCB) system and glucocorticoids, which lays the foundation for future studies of these systems testing specific interventions for these patients. This proposal is a 2-year study involving N=10 medication free weight restored women with AN (AN REC) and 10 healthy age and weight matched controls (CONT) to participate in one magnetic resonance imaging (MRI), one PET study, and hormonal assessments. We propose a model that in AN the maladaptive neurobehavioral response related to weight regulation results from impaired eCB signaling and insufficient neuroendocrine signaling. ) PUBLIC HEALTH RELEVANCE: This project aims to provide a translational model of the maladaptive processes associated with weight regulation in anorexia nervosa but in addition to lay the foundation to develop novel treatment developments for this patient population. Our proposal aims to provide an integrative view on the functions of two major stress-response systems, the endocannabinoid (eCB) system and glucocorticoids, which lays the foundation for future studies of these systems testing specific interventions for these patients. This proposal is a 2-year study involving N=10 medication free weight restored women with AN (AN REC) and 10 healthy age and weight matched controls (CONT) to participate in one magnetic resonance imaging (MRI), one PET study, and hormonal assessments.