Kappa Opioid Receptor Imaging in PTSD

描述（由申请人提供）：该项目旨在提供一个翻译模型的适应性和适应不良反应的主要压力源与创伤的潜力，不仅提供新的洞察创伤后应激障碍的病因，但除了指导新的治疗发展与创伤后应激障碍患者。我们的建议旨在提供两个主要的应激反应系统，κ阿片受体系统和糖皮质激素的功能，这为这些系统的未来研究奠定了基础，测试这些患者的具体干预措施。本研究计划为期3年，共纳入30名未接受过药物治疗的受试者，分为3个研究组[PTSD，n=10;创伤暴露的健康对照受试者（TC），n=10;非创伤暴露的健康对照受试者（HC），n=10;年龄范围18-50岁，每个队列中男女人数相等]通过公开广告招募，并邀请他们参加医学和精神病评估，神经内分泌评估，一项使用[11 C] LY 2795050和PET的κ阿片受体MRI研究和一项PET研究。 公共卫生相关性：该提案旨在确定kappa阿片受体（k-OR）在PTSD病理生理学中的潜在作用。我们计划招募PTSD患者以及有和无创伤暴露的健康对照受试者，并将使用新型选择性k-OR放射性配体[11 C] LY 2795050和正电子发射断层扫描（PET）研究体内k-OR。这项研究将首次确定这种阿片受体亚型在PTSD中的作用，并可能为该患者群体的新治疗开发奠定基础。

DESCRIPTION (provided by applicant): This project aims to provide a translational model of adaptive and maladaptive responses to major stressors associated with trauma with the potential to not only provide novel insight into the etiology of PTSD but in addition to guide nove treatment developments for patients with PTSD. Our proposal aims to provide an integrative view on the functions of two major stress-response systems, the kappa opioid receptor system and glucocorticoids, which lays the foundation for future studies of these systems testing specific interventions for these patients. This proposal is a 3-year study involving thirty drug-naive participants in three study groups [PTSD, n=10; trauma-exposed healthy control subjects (TC), n=10; non trauma-exposed healthy control subjects (HC), n=10; age range 18-50 years, equal numbers of men and women in each cohort] who are to be recruited through public advertisement and invited to participate in a medical and psychiatric evaluation, neuroendocrine assessments, one MRI study and one PET study of kappa opioidreceptors using [11C]LY2795050 and PET. PUBLIC HEALTH RELEVANCE: This proposal aims to determine the potential role of kappa opioid receptors (k-OR) in the pathophysiology of PTSD. We propose to recruit patients with PTSD, as well as healthy control subjects with and without trauma exposure and will study k-ORs in vivo using the novel selective k-OR radioligand [11C]LY2795050 and positron emission tomography (PET). This study will for the first time determine the role of this opoid receptor subtype in PTSD and may lay the foundation for novel treatment developments for this patient population.