Kappa Opioid Receptor Imaging in PTSD

描述（由申请人提供）：本项目旨在提供与创伤相关的主要压力源的适应和不适应反应的转化模型，不仅有可能为创伤后应激障碍的病因提供新的见解，而且还可以指导创伤后应激障碍患者的治疗发展。我们的建议旨在提供两个主要的应激反应系统，kappa阿片受体系统和糖皮质激素的功能的综合观点，为这些系统的未来研究奠定基础，为这些患者测试特定的干预措施。该提案是一项为期3年的研究，涉及30名未用药的参与者，分为三个研究组[PTSD， n=10；创伤暴露健康对照（TC）， n=10；非创伤暴露健康对照（HC）， n=10；年龄范围18-50岁，每组男女人数相等]，通过公开广告招募，邀请他们使用[11C]LY2795050和PET进行kappa阿片受体的医学和精神评估、神经内分泌评估、一项MRI研究和一项PET研究。

DESCRIPTION (provided by applicant): This project aims to provide a translational model of adaptive and maladaptive responses to major stressors associated with trauma with the potential to not only provide novel insight into the etiology of PTSD but in addition to guide nove treatment developments for patients with PTSD. Our proposal aims to provide an integrative view on the functions of two major stress-response systems, the kappa opioid receptor system and glucocorticoids, which lays the foundation for future studies of these systems testing specific interventions for these patients. This proposal is a 3-year study involving thirty drug-naive participants in three study groups [PTSD, n=10; trauma-exposed healthy control subjects (TC), n=10; non trauma-exposed healthy control subjects (HC), n=10; age range 18-50 years, equal numbers of men and women in each cohort] who are to be recruited through public advertisement and invited to participate in a medical and psychiatric evaluation, neuroendocrine assessments, one MRI study and one PET study of kappa opioidreceptors using [11C]LY2795050 and PET.