CB1 Receptor PET Imaging Reveals Gender Differencesin PTSD

CB1 受体 PET 成像揭示 PTSD 中的性别差异

• 批准号: 8494093
• 负责人: ALEXANDER NEUMEISTER
• 金额: $ 39.82万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8494093
• 关键词: Age; Agonist; Amygdaloid structure; Animals; Anterior; Anxiety; Behavior; Brain; Brain region; CNR1 gene; Cannabinoids; Chronic stress; Clinical; Cognitive; Data; Development; Diagnosis-Related Groups; Disease; Emotional; Endocannabinoids; Exposure to; Extinction (Psychology); Female; Fright; Gender; Gonadal Hormones; High Risk Woman; Hippocampus (Brain); Human; Hydrocortisone; Image; Lead; Learning; Link; Measures; Mediating; Memory; Modeling; Molecular; Molecular Target; Moods; Neurobiology; Neurotransmitters; Odds Ratio; Oral Contraceptives; Participant; Patients; Perimenopause; Pharmaceutical Preparations; Phenotype; Positron-Emission Tomography; Post-Traumatic Stress Disorders; Postmenopause; Prevalence; Process; Recording of previous events; Recruitment Activity; Regulation; Relative (related person); Reporting; Research; Rodent; Role; Scanning; Sex Characteristics; Signal Transduction; Stress; Symptoms; System; Time; Tracer; Trauma; United States National Institutes of Health; Up-Regulation; Ventral Striatum; Walkers; Woman; base; behavior measurement; biological adaptation to stress; cingulate cortex; clinical epidemiology; frontal lobe; improved; in vivo; male; men; neurobiological mechanism; neurochemistry; proliferative phase Menstrual cycle; protein expression; prototype; radioligand; radiotracer; receptor; receptor density; receptor expression; receptor upregulation; response; service intervention; sexual trauma; social; ward

DESCRIPTION (provided by applicant): Despite the widely acknowledged gender differences in the prevalence and clinical course of posttraumatic stress disorder (PTSD), there exists a paucity of data on the neurobiological mechanisms that explain these reported gender disparities in PTSD; therefore, better understanding of neurobiological sex differences has the potential to provide understanding of the neurobiology of PTSD and will also lead to improving interventions and services for males and females. We propose to recruit N=12 medication-free female patients with civilian PTSD, measure their CB1 receptor-selective radioligand [11C]OMAR volumes of distribution (VT), an equivalent of CB1 receptor expression using PET and compare them with 12 men with PTSD, as well as individually age, gender and BMI-matched controls with (TC, N=24) and without (HC, N=24) trauma history. This will answer the key question of this application if there exist a sex difference in stress responsiveness on a receptor level resultant in elevated CB1 protein expression in PTSD women in a PTSD circuit.

描述（由申请人提供）：尽管人们普遍承认创伤后应激障碍（PTSD）的患病率和临床病程存在性别差异，但仍缺乏关于解释这些报告的 PTSD 性别差异的神经生物学机制的数据；因此，更好地了解神经生物学性别差异有可能有助于理解创伤后应激障碍的神经生物学，也将改善针对男性和女性的干预措施和服务。我们建议招募 N = 12 名未接受药物治疗的平民 PTSD 女性患者，测量其 CB1 受体选择性放射性配体 [11C]OMAR 分布体积 (VT)，相当于使用 PET 的 CB1 受体表达，并将其与 12 名患有 PTSD 的男性以及单独年龄、性别和 BMI 匹配的对照组（TC，N = 24）和无（HC，N = 24）进行比较 外伤史。如果受体水平上的应激反应存在性别差异，从而导致 PTSD 回路中 PTSD 女性的 CB1 蛋白表达升高，这将回答本申请的关键问题。