KOR Depression

韩国萧条

• 批准号: 8719701
• 负责人: ALEXANDER NEUMEISTER
• 金额: $ 43.8万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8719701
• 关键词: Acute; Amygdaloid structure; Anhedonia; Animal Model; Animals; Anxiety; Brain; Brain region; Corticotropin-Releasing Hormone; Data; Depressed mood; Depressive Syndromes; Diagnostic; Dynorphins; Etiology; Fright; Gender Role; Glucocorticoids; Hour; Human; Hydrocortisone; Individual; Lead; Measures; Mediating; Mediator of activation protein; Membrane; Mental Depression; National Institute of Mental Health; Nature; Neurobiology; Opioid Receptor; Outcome; Participant; Pharmaceutical Preparations; Phenotype; Positron-Emission Tomography; Proteins; Psychopathology; Recruitment Activity; Research Domain Criteria; Rewards; Role; Severities; Signal Transduction; Stress; Symptoms; System; Time; Urine; Ventral Striatum; Woman; Work; base; depressive symptoms; improved; in vivo; kappa opioid receptors; men; public health relevance; radioligand; receptor; receptor coupling; receptor internalization; response; service intervention; sex

DESCRIPTION (provided by applicant): The kappa opioid receptor (KOR) has been implicated in the etiology of fear, threat, and anhedonia in animal models of human depression psychopathology. Herein, we propose to study the KOR in vivo using positron emission tomography, and we will also measure the activity of the HPA-axis in all study participants. We propose to recruit up to N=50 medication-free individuals using a transdiagnostic approach, measure their KOR-selective radioligand [11C]LY2795050 volumes of distribution (VT), an equivalent of KOR availability using PET and study the role of the KOR in mediating the quality and severity of the depressive phenotype. This application is in response to the RDoC initiative of NIMH to clarify the role of the KOR in mediating fear, threat, and reward responsiveness.

描述（由申请人提供）：kappa阿片受体（KOR）在人类抑郁精神病理动物模型中与恐惧、威胁和快感缺乏的病因有关。在此，我们建议使用正电子发射断层扫描来研究体内的KOR，我们还将测量所有研究参与者的hpa轴的活性。我们建议使用一种诊断方法招募多达N=50名无药物治疗的个体，测量他们的KOR选择性放射配体[11C]LY2795050分布体积（VT），相当于使用PET的KOR可用性，并研究KOR在调节抑郁表型质量和严重程度中的作用。这个申请是对NIMH的RDoC倡议的回应，该倡议澄清了KOR在调解恐惧，威胁和奖励反应中的作用。