CB1 Receptor PET Imaging Reveals Gender Differencesin PTSD

CB1 受体 PET 成像揭示 PTSD 中的性别差异

• 批准号: 8680371
• 负责人: ALEXANDER NEUMEISTER
• 金额: $ 9.21万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8680371
• 关键词: Age; Agonist; Amygdaloid structure; Animals; Anterior; Anxiety; Behavior; Brain; Brain region; CNR1 gene; Cannabinoids; Chronic stress; Clinical; Cognitive; Data; Development; Diagnosis-Related Groups; Disease; Emotional; Endocannabinoids; Exposure to; Extinction (Psychology); Female; Fright; Gender; Gonadal Hormones; High Risk Woman; Hippocampus (Brain); Human; Hydrocortisone; Image; Lead; Learning; Link; Measures; Mediating; Memory; Modeling; Molecular; Molecular Target; Moods; Neurobiology; Neurotransmitters; Odds Ratio; Oral Contraceptives; Participant; Patients; Perimenopause; Pharmaceutical Preparations; Phenotype; Positron-Emission Tomography; Post-Traumatic Stress Disorders; Postmenopause; Prevalence; Process; Recording of previous events; Recruitment Activity; Regulation; Relative (related person); Reporting; Research; Rodent; Role; Scanning; Sex Characteristics; Signal Transduction; Stress; Symptoms; System; Time; Tracer; Trauma; United States National Institutes of Health; Up-Regulation; Ventral Striatum; Walkers; Woman; base; behavior measurement; biological adaptation to stress; cingulate cortex; clinical epidemiology; frontal lobe; improved; in vivo; male; men; neurobiological mechanism; neurochemistry; proliferative phase Menstrual cycle; protein expression; prototype; radioligand; radiotracer; receptor; receptor density; receptor expression; receptor upregulation; response; service intervention; sexual trauma; social; ward

DESCRIPTION (provided by applicant): Despite the widely acknowledged gender differences in the prevalence and clinical course of posttraumatic stress disorder (PTSD), there exists a paucity of data on the neurobiological mechanisms that explain these reported gender disparities in PTSD; therefore, better understanding of neurobiological sex differences has the potential to provide understanding of the neurobiology of PTSD and will also lead to improving interventions and services for males and females. We propose to recruit N=12 medication-free female patients with civilian PTSD, measure their CB1 receptor-selective radioligand [11C]OMAR volumes of distribution (VT), an equivalent of CB1 receptor expression using PET and compare them with 12 men with PTSD, as well as individually age, gender and BMI-matched controls with (TC, N=24) and without (HC, N=24) trauma history. This will answer the key question of this application if there exist a sex difference in stress responsiveness on a receptor level resultant in elevated CB1 protein expression in PTSD women in a PTSD circuit.

描述（申请人提供）：尽管创伤后应激障碍（PTSD）的患病率和临床病程存在广泛的性别差异，但缺乏关于神经生物学机制的数据来解释这些报告的PTSD性别差异;因此，在本发明中，更好地理解神经生物学性别差异有可能提供对PTSD神经生物学的理解，也将导致改善为男性和女性提供干预和服务。我们建议招募N=12名无药物治疗的平民PTSD女性患者，使用PET测量其CB 1受体选择性放射性配体[11 C]OMAR分布容积（VT），相当于CB 1受体表达，并将其与12名PTSD男性患者以及单独年龄，性别和BMI匹配的对照组（TC，N=24）和无创伤史（HC，N=24）进行比较。这将回答本申请的关键问题，即在PTSD回路中，是否存在导致PTSD女性中CB 1蛋白表达升高的受体水平上的应激反应性的性别差异。