Research Training in the Major Psychoses and Clinical Neurobiology

描述（由申请人提供）：本申请要求继续资助一个非常成功和完善的博士后培训计划（可追溯到1991年），主要精神病和转化临床神经科学。它寻求将转化临床神经科学的培训与使用“生命轨迹视角”研究精神分裂症和其他主要精神病的重点相结合。也就是说，受训者可以在他们的典型发病年龄研究疾病，但他们也可以从神经发育和/或衰老过程的角度来研究疾病。综合转化临床神经科学课程将着重强调三个方面：“综合”、“转化/临床”和“神经科学”。最终目标是培养一批年轻的研究人员，他们将在神经科学的某些特定领域，如神经影像学、认知神经科学和遗传学/基因组学/分子生物学，结合对临床现象复杂性的高水平的复杂性和坚实的基础。该项目每年支持5个培训名额。受训者至少要在这个项目中呆两年，许多人选择继续他们的培训，总共三年，因为做复杂的综合转化临床神经科学固有的复杂性。进入该项目的最低经验要求是博士学位（M.D., Ph.D），但我们的许多学员也完成了住院医师培训并拥有医学博士/博士学位。我们希望，基础科学和临床科学的结合将有助于确定主要精神病的机制和原因，并提出治疗或预防这些疾病的改进方法。根据世界卫生组织最近的一项研究，通过这个项目研究的疾病（精神分裂症、抑郁症和双相情感障碍）是“全球疾病负担”的十大贡献者中的三个。因此，至关重要的是，我们要培养年轻一代的研究人员，他们将在未来几十年里推进对这些疾病的认识。

DESCRIPTION (provided by applicant): This application requests continuation of funding for a very successful and well-established post-doctoral training program (dating back to 1991) in Major Psychoses and Translational Clinical Neuroscience. It seeks to integrate training in translational clinical neuroscience with an emphasis on the study of schizophrenia and other major psychoses using a "lifespan trajectory perspective." That is, trainees may study illnesses during their characteristic age of onset, but they may also examine them from the perspectives of neurodevelopmental and/or aging processes. This program in integrative translational clinical neuroscience will place strong emphasis on all three aspects: "integrative," "translational/clinical," and "neuroscience." The ultimate goal is to train a group of young investigators who will combine a high level of sophistication about the complexities of clinical phenomena with a firm grounding in some specific area of neuroscience, such as neuroimaging, cognitive neuroscience, and genetics/genomics/molecular biology. The program supports five trainee slots/year. Trainees remain in the program for a minimum of two years, and many elect to continue their training for a total of three years because of the complexities inherent in doing sophisticated integrative translational clinical neuroscience. The minimum experience required for entry into the program is a doctoral degree (M.D., Ph.D.), but many of our trainees have also completed residency training and have M.D./Ph.D.s. Relevance An integration of basic and clinical science will, we hope, help identify the mechanisms and causes of the major psychoses and to suggest improved methods for treating or preventing them. The disorders studied through this program (schizophrenia, depression, and bipolar illness) are three of the top ten contributors to the "global burden of disease," according to a recent study by the World Health Organization. Thus it is crucial that we train a young generation of investigators who will advance knowledge about these diseases over the coming decades.