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Degenerative changes in the taste system

味觉系统的退行性变化

基本信息

批准号：
8413453
负责人：
LYNNETTE Marie MCCLUSKEY
金额：
$ 25.59万
依托单位：
AUGUSTA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-07-01 至 2015-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8413453
关键词：
Accounting Adult Affect Amiloride Animal Feed Anterior Apoptosis Award Bilateral Cell Communication Cell physiology Cells Contralateral Diet Dietary Sodium Epithelial Equilibrium Functional Imaging Gray unit of radiation dose Health Immune Immune response Immune system Injury Interleukin-12 Interleukins Lead Left Leukocytes Maps Mediating Natural regeneration Nerve Neurons Peripheral nerve injury Play Population Proteins Rattus Receptor Cell Recruitment Activity Resolution Right-On Role Sagittaria Sensory Sensory Receptors Side Site Sodium Sodium Channel Stimulus System Taste Buds Taste Perception Testing Tongue Vascular Cell Adhesion Molecule-1 Work afferent nerve anakinra chorda tympani cytokine epithelial Na+ channel feeding immune activation in vivo injured macrophage nerve injury neurophysiology neutrophil prevent receptor relating to nervous system response response to injury

项目摘要

Description (provided by applicant): Peripheral nerve injury has effects that extend beyond damaged neurons. However, the impact of injury on neighboring sensory fields is not well understood. We propose that immune cells, or "leukocytes", mediate changes in taste function. Macrophages respond to nerve injury, and extend to uninjured regions of the tongue. These leukocytes are predictive of normal neural taste responses. Neutrophils are also part of the immune response to injury, but they appear to have a negative effect on taste function. Neural injury alters sodium transduction in taste receptor cells, suggesting that the epithelial sodium channel (ENaC) is the site of functional plasticity. We will test the following hypotheses: (1) Neutrophils are the initial immune responders to gustatory nerve injury, and they induce deficits in taste function; (2) Nerve injury and leukocytes modulate ENaC expression and/or function; and (3) IL-12, a proinflammatory cytokine, maintains normal taste function after injury by promoting a balanced immune response. Resolution of these hypotheses will increase our understanding of dynamic immune responses to neural injury and their beneficial and harmful effects on sensory receptor cells.

描述（由申请人提供）：周围神经损伤的影响超出了受损的神经元。然而，损伤对邻近感觉野的影响尚不清楚。我们提出免疫细胞，或“白细胞”，介导味觉功能的变化。巨噬细胞对神经损伤有反应，并延伸到舌头的未损伤区域。这些白细胞可以预测正常的神经味觉反应。中性粒细胞也是对损伤的免疫反应的一部分，但它们似乎对味觉功能有负面影响。神经损伤改变了味觉受体细胞中的钠离子转导，表明上皮钠离子通道（ENaC）是功能可塑性的部位。我们将验证以下假设：(1)中性粒细胞是味觉神经损伤的初始免疫应答者，它们诱导味觉功能缺陷；(2)神经损伤和白细胞调节ENaC的表达和/或功能；(3) IL-12是一种促炎细胞因子，通过促进平衡的免疫反应来维持损伤后正常的味觉功能。这些假设的解决将增加我们对神经损伤的动态免疫反应及其对感觉受体细胞的有益和有害影响的理解。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Aging profoundly delays functional recovery from gustatory nerve injury.

DOI：
10.1016/j.neuroscience.2012.02.012
发表时间：
2012-05-03
期刊：
NEUROSCIENCE
影响因子：
3.3
作者：
He, L.;Yadgarov, A.;Sharif, S.;McCluskey, L. P.
通讯作者：
McCluskey, L. P.

Neutrophil responses to injury or inflammation impair peripheral gustatory function.

DOI：
10.1016/j.neuroscience.2010.02.056
发表时间：
2010-05-19
期刊：
Neuroscience
影响因子：
3.3
作者：
Steen PW;Shi L;He L;McCluskey LP
通讯作者：
McCluskey LP

Functional role for interleukin-1 in the injured peripheral taste system.

DOI：
10.1002/jnr.22798
发表时间：
2012-04
期刊：
JOURNAL OF NEUROSCIENCE RESEARCH
影响因子：
4.2
作者：
Shi, Liqiao;He, Lianying;Sarvepalli, Padma;McCluskey, Lynnette Phillips
通讯作者：
McCluskey, Lynnette Phillips

Regression of Lingual Lymphatic Vessels in Sodium-restricted Mice.

限钠小鼠舌淋巴管的退化。

DOI：
10.1369/0022155417749173
发表时间：
2018
期刊：
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
影响因子：
0
作者：
He,Lianying;McCluskey,LynnettePhillips
通讯作者：
McCluskey,LynnettePhillips

Ingestion of bacterial lipopolysaccharide inhibits peripheral taste responses to sucrose in mice.