Anterior Olfactory Nucleus

前嗅核

• 批准号: 8460919
• 负责人: PETER C BRUNJES
• 金额: $ 24.14万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-04-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8460919
• 关键词: Affect; Animals; Anterior; Area; Attention; Automobile Driving; Behavior; Brain; Cells; Cerebral cortex; Complement; Complex; Contralateral; Data; Decision Making; Denervation; Environment; Food Selections; Goals; Growth; Individual; Interneurons; Ipsilateral; Label; Lead; Life; Mammals; Maps; Mate Selections; Methods; Modality; Morphogenesis; Motor; Names; Neurons; Odors; Olfactory Mucosa; Olfactory Pathways; Output; Pathway interactions; Perception; Play; Process; Property; Prosencephalon; Research; Research Project Grants; Role; Sensory; Side; Smell Perception; Structure; Synapses; System; Testing; Tissues; Variant; Work; anterior commissure; basal forebrain; deprivation; design; gamma-Aminobutyric Acid; information processing; neocortical; neural circuit; olfactory bulb; olfactory nuclei; piriform cortex; public health relevance; regional difference; research study; sensory system

DESCRIPTION (provided by applicant): Sensory systems are the means by which people receive the information they need to navigate about the world. Of all of the major modalities olfaction is perhaps the least understood, despite the fact that it plays many important roles in our lives. The work described in the present proposal is designed to examine carefully a very important region in the central olfactory pathways. The anterior olfactory nucleus (AON) has synaptic connections at nearly every point of information processing on both the ipsilateral and contralateral side of the olfactory regions of the forebrain. As such, it is capable of driving or modulating the synaptic activity of the entire central olfactory system. Nevertheless, it has been virtually ignored compared with studies of the olfactory mucosa, bulb and piriform cortex. The proposed research will continue our examination of the AON's structure and function. The work has two major foci. First, while the region may have one name, it is becoming obvious that it contains several different processing areas and is therefore more complicated than initially believed. The primary goal of this research is to define functional subregions in the AON to build fundamental information about its organization. Second, the existence of crossed connections in the olfactory system has received very little attention. In nearly every sensory, motor and neocortical system crossed connections are important in facilitating complex information processing and the work examining them has led to enormous advances in understanding system function. Understanding the contributions of interhemispheric connections in the olfactory system will doubtlessly also lead to more a sophisticated view of the mechanisms of odor perception.

描述（由申请人提供）：感觉系统是人们接收他们在世界上导航所需信息的手段。尽管嗅觉在我们的生活中扮演着许多重要的角色，但在所有的主要形态中，它可能是最不为人所知的。本提案中描述的工作旨在仔细检查中央嗅觉通路中一个非常重要的区域。前嗅核（AON）在前脑嗅觉区同侧和对侧几乎每个信息处理点上都有突触连接。因此，它能够驱动或调节整个中央嗅觉系统的突触活动。然而，与嗅觉粘膜、球和梨状皮质的研究相比，它实际上被忽视了。建议的研究将继续我们对AON结构和功能的研究。这项工作有两个重点。首先，虽然该区域可能只有一个名称，但很明显，它包含几个不同的处理区域，因此比最初认为的要复杂得多。本研究的主要目标是定义AON的功能子区域，以建立其组织的基本信息。其次，嗅觉系统中存在的交叉连接很少受到关注。在几乎所有的感觉、运动和新皮层系统中，交叉连接在促进复杂信息处理方面都是重要的，对它们的研究已经在理解系统功能方面取得了巨大的进展。了解嗅觉系统中半球间连接的贡献，无疑也将导致对气味感知机制的更复杂的看法。