Olivocochlear Reflex in Humans

人类的橄榄耳蜗反射

基本信息

  • 批准号:
    8475441
  • 负责人:
  • 金额:
    $ 30.37万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2003
  • 资助国家:
    美国
  • 起止时间:
    2003-04-01 至 2015-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Despite work by many investigators, we still do not know the functional role of medial olivocochlear (MOC) efferents. In previous attempts to correlate MOC strength with subject performance, the passive response of the MOC acoustic reflex was measured, not the MOC activation during the task. We are now able to measure MOC activation during a psychophysical task, a new paradigm that greatly increases our ability to test MOC function and descending control in the human auditory system. MOC tests based on otoacoustic emission (OAE) measurements are being used both scientifically and clinically, but the accuracy of such tests has never been ascertained. To maximize the scientific and clinical usefulness of OAE tests we will: Aim (1A,B) Measure MOC effects using the three types of evoked OAEs and compare the resulting MOC-strength metrics in terms of signal/noise ratios and accuracy of subject ranking, using both contralateral and ipsilateral elicitors, and Aim (1C) determine, in humans, MOC reflex strength in terms of changes in cochlear sensitivity, as shown by MOC-induced changes in wave I of the auditory brainstem response. To address the functional significance of the MOC system, we will systematically measure MOC activation levels in psychophysical tasks: (Aim 2A-C) in which MOC activation is expected to aid performance (discrimination of transient signals in noise) vs. those in which no benefit is anticipated, and (Aim 2D-E) to determine MOC frequency selectivity in an active task. The MOC strength tests developed in this work should be useful in clinical and scientific contexts to predict susceptibility to noise damage, in the diagnosis and tracking of diseases, in evaluating the toxicity of drugs and to show the role of MOC feedback in normal hearing. The proposed work will also help to indicate the extent to which such feedback should be put in hearing aids and prosthetic devices such as cochlear implants.
描述(由申请人提供):尽管有许多研究者的工作,我们仍然不知道内侧耳蜗(MOC)传出神经的功能作用。在之前试图将MOC强度与受试者的表现联系起来时,测量的是MOC声反射的被动反应,而不是任务期间MOC的激活。我们现在能够在心理物理任务中测量MOC的激活,这一新的范式极大地提高了我们测试人类听觉系统中MOC功能和下行控制的能力。基于耳声发射(OAE)测量的MOC测试在科学上和临床上都得到了应用,但这种测试的准确性从未得到确定。为了最大限度地提高OAE测试的科学和临床用途,我们将:Aim (1A,B)使用三种类型的诱发OAE来测量MOC效应,并使用对侧和同侧激发子比较MOC强度指标的信噪比和受试者排名准确性;Aim (1C)根据MOC诱导的听觉脑干反应I波的变化来确定人类耳蜗敏感性变化的MOC反射强度。为了解决MOC系统的功能意义,我们将系统地测量心理物理任务中的MOC激活水平:(Aim 2A-C) MOC激活预计有助于性能(在噪声中识别瞬态信号)与那些没有预期益处的任务,以及(Aim 2D-E)确定主动任务中的MOC频率选择性。在这项工作中开发的MOC强度测试应该在临床和科学背景下有用,以预测对噪声损伤的易感性,疾病的诊断和跟踪,评估药物的毒性,并显示MOC反馈在正常听力中的作用。拟议的工作也将有助于指出这种反馈应该在多大程度上用于助听器和人工耳蜗植入等假肢装置。

项目成果

期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Efferent inhibition strength is a physiological correlate of hyperacusis in children with autism spectrum disorder.
传出抑制强度是自闭症谱系障碍儿童听觉过敏的生理相关因素。
  • DOI:
    10.1152/jn.00142.2017
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    2.5
  • 作者:
    Wilson,UzmaS;Sadler,KateM;Hancock,KennethE;GuinanJr,JohnJ;Lichtenhan,JefferyT
  • 通讯作者:
    Lichtenhan,JefferyT
Olivocochlear efferent function: issues regarding methods and the interpretation of results.
橄榄耳蜗传出功能:有关方法和结果解释的问题。
Medial olivocochlear efferent reflex inhibition of human cochlear nerve responses.
内侧橄榄耳蜗传出反射抑制人类耳蜗神经反应。
  • DOI:
    10.1016/j.heares.2015.09.001
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    2.8
  • 作者:
    Lichtenhan,JT;Wilson,US;Hancock,KE;GuinanJr,JJ
  • 通讯作者:
    GuinanJr,JJ
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

JOHN J GUINAN其他文献

JOHN J GUINAN的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('JOHN J GUINAN', 18)}}的其他基金

ENGINEERING CORE
工程核心
  • 批准号:
    8071121
  • 财政年份:
    2010
  • 资助金额:
    $ 30.37万
  • 项目类别:
ENGINEERING CORE
工程核心
  • 批准号:
    7620372
  • 财政年份:
    2008
  • 资助金额:
    $ 30.37万
  • 项目类别:
ENGINEERING CORE
工程核心
  • 批准号:
    7250480
  • 财政年份:
    2007
  • 资助金额:
    $ 30.37万
  • 项目类别:
Olivocochlear Reflex in Humans
人类的橄榄耳蜗反射
  • 批准号:
    6727453
  • 财政年份:
    2003
  • 资助金额:
    $ 30.37万
  • 项目类别:
Olivocochlear Reflex in Humans
人类的橄榄耳蜗反射
  • 批准号:
    7021418
  • 财政年份:
    2003
  • 资助金额:
    $ 30.37万
  • 项目类别:
Olivocochlear Reflex in Humans
人类的橄榄耳蜗反射
  • 批准号:
    7878571
  • 财政年份:
    2003
  • 资助金额:
    $ 30.37万
  • 项目类别:
Olivocochlear Reflex in Humans
人类的橄榄耳蜗反射
  • 批准号:
    7735762
  • 财政年份:
    2003
  • 资助金额:
    $ 30.37万
  • 项目类别:
Olivocochlear Reflex in Humans
人类的橄榄耳蜗反射
  • 批准号:
    6851708
  • 财政年份:
    2003
  • 资助金额:
    $ 30.37万
  • 项目类别:
Olivocochlear Reflex in Humans
人类的橄榄耳蜗反射
  • 批准号:
    8279363
  • 财政年份:
    2003
  • 资助金额:
    $ 30.37万
  • 项目类别:
Olivocochlear Reflex in Humans
人类的橄榄耳蜗反射
  • 批准号:
    7174746
  • 财政年份:
    2003
  • 资助金额:
    $ 30.37万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 30.37万
  • 项目类别:
    Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 30.37万
  • 项目类别:
    Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 30.37万
  • 项目类别:
    Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 30.37万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 30.37万
  • 项目类别:
    Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 30.37万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 30.37万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 30.37万
  • 项目类别:
    EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 30.37万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 30.37万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了