ARIC Neurocognitive Study (ARIC-NCS)

ARIC 神经认知研究 (ARIC-NCS)

基本信息

批准号：
8463861
负责人：
Alvaro Alonso
金额：
$ 109.77万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-07 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8463861
关键词：
Accounting Affect African African American Age Aging Alzheimer&apos s Disease Ancillary Study Anger Apolipoprotein E Arterioloscleroses Aspirin Atherosclerosis Atrial Fibrillation Atrophic Autopsy Benefits and Risks Biological Assay Blood Blood Vessels Brain Brain region Cardiovascular system Carotid Atherosclerotic Disease Case Study Cerebrovascular Disorders Cerebrum Cognitive Cohort Studies Collaborations Communities Comorbidity Coronary Artery Bypass Coronary heart disease Creatinine Degenerative Disorder Dementia Diabetes Mellitus Diabetic Angiopathies Diagnosis Diet Disease Disease Marker Elderly Evaluation Event Exudate Fibrin fragment D Future Genetic Determinism Genome Genomics Genotype Glycosylated hemoglobin A Health Heart failure Hemostatic Agents High Prevalence Hippocampus (Brain)Hypertension Impaired cognition Incidence Infarction Inflammatory Insulin Intervention Life Style MRI Scans Magnetic Resonance Imaging Measurement Measures Medial Medical Medical Records Memory Mental Depression Methods Microalbuminuria Microaneurysm Modification Myocardial Infarction Neurocognitive Obesity Observational Study Onset of illness Operative Surgical Procedures Orthostatic Hypotension Outcome Participant Pathway interactions Peripheral arterial disease Persons Pharmaceutical Preparations Photography Physical activity Plasma Plasminogen Population Predisposition Prevalence Prevention strategy Process Process Measure Prospective Studies Race Regional Disease Research Retinal Retinal Hemorrhage Risk Risk Factors Risk Marker Smoking Social support Socioeconomic Factors Staging Stroke Structure Survivors Temporal Lobe Testing Thick Time Urine VWF gene Vascular Dementia Vascular Diseases White Matter Disease aged base brain volume cardiovascular risk factor case control cerebrovascular cognitive change cognitive function cohort cost design executive function follow-up genome wide association study heart rate variability indexing macrovascular disease middle age mild cognitive impairment mortality novel prevent processing speed prospective psychosocial public health relevance sex therapeutic target vascular factor

项目摘要

DESCRIPTION (provided by applicant): Dementia and mild cognitive impairment (MCI) pose a large and increasing health and societal burden on the aging US population. New studies suggest that microvascular disease makes a substantial contribution to dementia and MCI. A few long-followed cohorts show strong associations of mid-life hypertension, diabetes, and smoking with dementia at older age in contrast to weak associations in studies of the elderly. An observational study relating dementia, MCI and cerebral changes observable on MRI to midlife vascular risk factors has the promise of suggesting dementia prevention strategies where none currently exist. Aims: The proposed ARIC Neurocognitive study (ARIC-NCS) will focus on prediction of cognitive impairment from mid-life vascular risk factors and markers through a 5 center R01 ancillary study to the large, bi-ethnic prospective ARIC cohort study. Prediction is expected to be particularly strong in African-Americans and persons whose dementia or MCI is diagnosed as vascular or accompanied by MRI cerebrovascular signs. Aims are to: 1) estimate the prevalence of dementia/MCI by race and sex in participants aged 70-89, 2) determine whether midlife vascular factors (risk factors and markers of macrovascular and microvascular disease) predict dementia, MCI and cognitive change, 3) determine whether the associations between midlife vascular factors and dementia/MCI differ by dementia/MCI subtype defined clinically or by MRI signs, 4) identify cerebral markers associated with cognitive change, including progression of MRI ischemic burden and atrophy across 3 MRI scans spanning 17 years, and 5) identify genomic regions containing susceptibility loci for cognitive decline, using 106 SNPs spanning the genome. Design/Methods: Prospective study of >7000 residents aged 70-89 in 4 US communities adding a 24-year follow-up evaluation with detailed neurocognitive assessment, retinal photography, lab assays and medical record review to 4 previous exams (1987-1999) which included midlife cognitive testing. Two thousand dementia and MCI cases and controls will undergo cerebral MRI with central measurement of cerebrovascular signs and brain volumes. ARIC is uniquely situated for this research since predictors already measured include macrovascular (carotid thickness, plaque and distensibility, peripheral artery disease) and microvascular markers (retinal arteriolar narrowing and nicking, retinal hemorrhage, exudates, and microaneurysms, microalbuminuria), cardiovascular events, hemostatic factors in 5 pathways, apoE, 106 SNPs across the genome, all major cardiovascular risk factors, and in many participants, one or two prior cerebral MRI exams. Implications: Longitudinal observational study of midlife vascular risk factors for cognitive and cerebral changes in the ARIC cohort will elucidate factors underlying ethnic disparities in dementia burden and provide the scientific basis for prevention strategies by identifying vascular therapeutic targets, optimal timing for interventions and useful intermediate outcomes.

描述（由申请人提供）：痴呆症和轻度认知障碍（MCI）对美国老龄化人群造成了巨大的健康和社会负担。新研究表明，微血管疾病对痴呆症和MCI做出了重大贡献。与老年人研究中的弱关联相比，一些长期遵循的队列显示了中年高血压，糖尿病和吸烟与痴呆症的牢固联系。一项有关痴呆，MCI和大脑变化的观察性研究可在MRI到中年血管危险因素可观察到的变化有望暗示目前不存在的痴呆症预防策略。目的：拟议的ARIC神经认知研究（ARIC-NC）将重点关注从中期血管危险因素和标记物通过5个中心R01辅助研究到大型，双种族的前瞻性Aric同胞研究的认知障碍的预测。预计在非洲裔美国人和痴呆症或MCI被诊断为血管或伴有MRI脑血管症状的人中，预测将特别强大。目的是：1）在70-89岁的参与者中估算种族和性别的痴呆/MCI的流行率，2）确定中期血管因素（大血管和微血管疾病的危险因素和标志物）是否可以预测痴呆症，MCI和认知变化，3）确定中等疾病/MC之间的相关性，是否确定降级型和降级的相关性。通过MRI符号，4）确定与认知变化相关的脑标志物，包括在跨越17年的3次MRI扫描中MRI缺血负担和萎缩的进展，以及5）确定使用跨基因组的106个SNP的认知能力下降的基因组区域。设计/方法：在4个美国社区中70-89岁的> 7000名居民的前瞻性研究增加了24年的随访评估，其中包括详细的神经认知评估，视网膜摄影，实验室分析和医疗记录审查，包括4个先前的考试（1987-1999），其中包括中年认知测试。两千名痴呆症和MCI病例和对照组将通过脑血管体征和脑体积的中心测量进行大脑MRI。 ARIC is uniquely situated for this research since predictors already measured include macrovascular (carotid thickness, plaque and distensibility, peripheral artery disease) and microvascular markers (retinal arteriolar narrowing and nicking, retinal hemorrhage, exudates, and microaneurysms, microalbuminuria), cardiovascular events, hemostatic factors in 5 pathways, apoE, 106 SNPs在整个基因组中，所有主要的心血管危险因素，在许多参与者中，一两个先前的脑MRI检查。含义：对ARIC队列中认知和脑变化的中年血管危险因素的纵向观察研究将阐明痴呆负担中种族差异的基本因素，并通过确定血管疗法的识别策略的科学基础，以确定干预措施和有用的中等中等中等阶层。