Mentoring in patient-oriented atrial fibrillation and cardiovascular research
指导以患者为中心的心房颤动和心血管研究
基本信息
- 批准号:9806450
- 负责人:
- 金额:$ 11.85万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-15 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAreaArrhythmiaAtrial FibrillationAwardBlood specimenCardiac Catheterization ProceduresCardiac ablationCardiologyCardiovascular DiseasesCardiovascular systemCharacteristicsClassificationClinicalClinical DataClinical InvestigatorClinical ManagementCluster AnalysisCoronary ArteriosclerosisDataDevelopmentDoctor of PhilosophyEnrollmentEnvironmentEpidemiologyEtiologyFellowship ProgramFunctional disorderFundingGenomicsGoalsGrantHeart AtriumHeart failureHeterogeneityHospitalsImageIncidenceIndividualIschemic StrokeKnowledgeLeadLife StyleLiteratureMachine LearningMaster of Public HealthMentorsMethodologyMultiomic DataNational Heart, Lung, and Blood InstituteOutcomeParticipantPatientsPatternPhenotypePopulationPreventionPrevention strategyPreventive InterventionPrincipal InvestigatorProcessPublic HealthPublic Health SchoolsResearchResearch ActivityResearch PersonnelResearch Project GrantsResourcesRiskRisk FactorsStratificationStrokeSurvival AnalysisTechniquesTechnologyTherapeuticTherapeutic InterventionTimeTrainingTraining ProgramsUniversitiesWorkbasebiobankcandidate selectioncardiovascular disorder epidemiologycardiovascular healthcareer developmentgraduate studenthealth disparityhigh risk populationinnovationinterestmedical schoolsmetabolomicsmortalitymultidisciplinarymultiple omicsnovelnovel therapeutic interventionoutcome forecastpatient orientedpatient oriented researchpatient registrypatient subsetspreventprogramsprospectiveprotein biomarkersskill acquisitionskillssociodemographicstranscriptomicstrend
项目摘要
PROJECT SUMMARY
This application will provide the Principal Investigator, Dr. Alvaro Alonso, with protected time and other support
to (1) accelerate a successful record of mentoring junior clinical investigators and graduate students engaged
in patient-oriented cardiovascular research; (2) obtain additional training in omics, machine learning, and
mentoring best-practices; and (3) advance Dr. Alonso's ongoing research on the risk factors and mechanisms
contributing to the development of atrial fibrillation (AF). Mentoring activities will build upon the ongoing
involvement of Dr. Alonso in several training programs at Emory University, including an NHLBI-funded
multidisciplinary T32 training grant on cardiovascular health disparities, the research-track Cardiology
fellowship program at the School of Medicine, and the Master of Public Health and PhD programs in
epidemiology at the Rollins School of Public Health. Training will focus on cutting-edge methodological areas in
rapid development, including integration of omic technologies and machine learning in patient-oriented
research, as well as acquisition of skills in academic, research, and clinical mentoring. Finally, this award will
support a research project that extends Dr. Alonso's ongoing work on understanding the factors influencing the
development of the AF substrate, understanding AF pathophysiology, and preventing AF-related outcomes.
The specific aims of this research are: (1) to identify novel AF phenotypes (phenogroups) using extensive
clinical and multi-omic data (“phenomapping”), (2) to discover specific risk factors for the different AF
phenogroups, and (3) to determine associations of AF phenogroups with selected endpoints (stroke, heart
failure, mortality). These research aims will be carried out in the context of the Emory Cardiovascular Biobank,
an ongoing prospective registry of patients undergoing cardiac catheterization in three Emory-affiliated
hospitals currently including approximately 7,000 unique individuals with detailed phenotyping, clinical
outcomes, and multi-omic markers. In summary, the activities proposed in this application will favorably impact
Dr. Alonso's capabilities to conduct cutting-edge and innovative patient-oriented research on cardiovascular
prevention and his ability to perform as a highly qualified mentor for junior clinicians pursuing research on
clinical cardiovascular epidemiology and prevention.
项目摘要
本申请将为主要研究者Alvaro Alonso博士提供受保护的时间和其他支持
(1)加快指导初级临床研究者和研究生的成功记录
在以患者为导向的心血管研究中;(2)获得组学,机器学习和
指导最佳实践;(3)推进阿隆索博士正在进行的关于风险因素和机制的研究
导致心房颤动(AF)的发展。指导活动将建立在正在进行的
阿隆索博士参与埃默里大学的几个培训项目,包括一个由NHLBI资助的
关于心血管健康差异的多学科T32培训补助金,研究跟踪心脏病学
医学院的奖学金计划,以及公共卫生硕士和博士课程,
罗林斯公共卫生学院的流行病学。培训将侧重于以下方面的前沿方法领域:
快速发展,包括将组学技术和机器学习整合到以患者为导向的
研究,以及在学术,研究和临床指导技能的收购。最后,该奖项将
支持一个研究项目,该项目扩展了阿隆索博士正在进行的关于了解影响
AF底物的发展,了解AF病理生理学,预防AF相关结局。
本研究的具体目的是:(1)使用广泛的方法鉴定新的AF表型(表型组),
临床和多组学数据(“现象图谱”),(2)发现不同AF的特定风险因素
表型组,以及(3)确定AF表型组与选定终点(中风、心脏病)的相关性
失败、死亡)。这些研究目标将在埃默里心血管生物库的背景下进行,
一项正在进行的前瞻性登记研究,对在三个埃默里附属医院接受心导管插入术的患者进行了登记。
医院目前包括大约7,000个具有详细表型、临床
结果和多组学标记。总之,本申请中提出的活动将有利地影响
博士Alonso在心血管领域进行尖端和创新的以患者为导向的研究的能力
预防和他的能力,作为一个高素质的导师,初级临床医生追求的研究,
临床心血管流行病学和预防。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Alvaro Alonso其他文献
Alvaro Alonso的其他文献
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{{ truncateString('Alvaro Alonso', 18)}}的其他基金
Mentoring in patient-oriented atrial fibrillation and cardiovascular research
指导以患者为中心的心房颤动和心血管研究
- 批准号:
10414916 - 财政年份:2019
- 资助金额:
$ 11.85万 - 项目类别:
Mentoring in patient-oriented atrial fibrillation and cardiovascular research
指导以患者为中心的心房颤动和心血管研究
- 批准号:
10179458 - 财政年份:2019
- 资助金额:
$ 11.85万 - 项目类别:
Mentoring in patient-oriented atrial fibrillation and cardiovascular research
指导以患者为中心的心房颤动和心血管研究
- 批准号:
9976580 - 财政年份:2019
- 资助金额:
$ 11.85万 - 项目类别:
Mentoring in patient-oriented atrial fibrillation and cardiovascular research
指导以患者为中心的心房颤动和心血管研究
- 批准号:
10657434 - 财政年份:2019
- 资助金额:
$ 11.85万 - 项目类别:
Effect of an Intensive Lifestyle Intervention on the Atrial Fibrillation Substrate
强化生活方式干预对心房颤动基质的影响
- 批准号:
10158273 - 财政年份:2018
- 资助金额:
$ 11.85万 - 项目类别:
Effect of an Intensive Lifestyle Intervention on the Atrial Fibrillation Substrate
强化生活方式干预对心房颤动基质的影响
- 批准号:
9926722 - 财政年份:2018
- 资助金额:
$ 11.85万 - 项目类别:
Effect of an Intensive Lifestyle Intervention on the Atrial Fibrillation Substrate
强化生活方式干预对心房颤动基质的影响
- 批准号:
10088010 - 财政年份:2018
- 资助金额:
$ 11.85万 - 项目类别:
Comparative Effectiveness of Oral Anticoagulants in Atrial Fibrillation
口服抗凝药治疗心房颤动的疗效比较
- 批准号:
8882953 - 财政年份:2015
- 资助金额:
$ 11.85万 - 项目类别:
Comparative Effectiveness of Oral Anticoagulants in Atrial Fibrillation
口服抗凝药治疗心房颤动的疗效比较
- 批准号:
9233180 - 财政年份:2015
- 资助金额:
$ 11.85万 - 项目类别:
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