Emory Alzheimer's Disease Research Center

摘要/摘要：数据管理和统计核心 埃默里·戈伊苏埃塔阿尔茨海默病研究的数据管理和统计(DMS)核心 中心(ADRC)支持关于阿尔茨海默病和相关疾病的病因、进展和治疗的研究 精神障碍(ADRD)。DMS核心通过将数据收集工作与 将管理、临床、教育和神经病理学核心整合到一个公共存储库中，监控 这些数据的完整性，并将信息及时传输给当地、国家、 以及国际层面和国家阿尔茨海默氏症协调中心。DMS核心也借出了他们的 研究人员在研究设计和分析方法方面的专业知识，合作并发起ADRC- 开展相关研究，并开发创新的统计方法和方法。在目前的资助期间 在此期间，Emory DMS Core在其基础设施上投入了大量资金，以创建一个集成、动态和 无障碍数据解决方案，包括部署基于网络的系统，以改进数据跟踪、集成、 和资源共享。DMS核心参与了更多关于赠款和同行审查的合作 出版物，并开发了新的创新方法来整合多组学数据和量化 尸检组织。 在下一个供资周期中，DMS核心将实现以下目标：(1)继续保持 科学严谨的研究数据库，支持NACC、ADRC核心、发展项目、地方 研究人员发起的研究、研究教育部分的受训人员和国家合作研究；(2) 就ADRC的设计、实施、分析和解释提供统计咨询和合作 相关研究和拨款；以及(3)开发创新方法，支持AD和 ADRD，特别强调遗传学、蛋白质组学、成像、 并结合临床资料进行分析。通过这些努力，利用和增强创建的数据基础架构 在过去的供资期间，并整合了核心调查人员的不同专业知识，DMS核心将 促进前沿研究，推动AD和ADRD领域的发展。

SUMMARY/ABSTRACT: DATA MANAGEMENT AND STATISTICS CORE The Data Management and Statistical (DMS) Core of the Emory Goizueta Alzheimer’s Disease Research Center (ADRC) supports studies on the causes, progression, and treatment of Alzheimer’s disease and related disorders (ADRD). The DMS Core accomplishes these goals by merging the data collection efforts of the Administrative, Clinical, Education, and Neuropathology Cores into a common repository, monitoring the integrity of these data, and transmitting the information in a timely fashion to investigators at the local, national, and international levels and to the National Alzheimer’s Coordinating Center. The DMS Core also lends their expertise on research design and analytic approaches to investigators, collaborates on and initiates ADRC- related studies, and develops innovative statistical approaches and methodologies. During the current funding period, the Emory DMS Core has invested heavily in its infrastructure to create an integrated, dynamic and accessible data solution, including deployment of web-based systems to improve data tracking, integration, and resource sharing. The DMS Core has engaged in increased collaborations on grants and peer-reviewed publications, and has developed new innovative methods to integrate multi-omics data and quantify postmortem tissue. In the next funding cycle, the DMS Core will achieve the following aims: (1) To continue to maintain a scientifically rigorous research database that supports NACC, the ADRC Cores, developmental projects, local investigator-initiated studies, Research Education Component trainees, and national collaborative studies; (2) To provide statistical consulting and collaboration on the design, conduct, analysis and interpretation of ADRC related studies and grants; and (3) To develop innovative methods to support biomarker research on AD and ADRD, with a special emphasis on methods for multi-modal integration of genetics, proteomics, imaging, together with the clinical data. Through these efforts, leveraging and enhancing data infrastructure created over the last funding period, and integrating the diverse expertise of Core investigators, the DMS Core will facilitate cutting edge research to advance the field of AD and ADRD.