Mentoring in patient-oriented atrial fibrillation and cardiovascular research

指导以患者为中心的心房颤动和心血管研究

• 批准号: 10414916
• 负责人: Alvaro Alonso
• 金额: $ 11.85万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10414916
• 关键词: Address; Area; Arrhythmia; Atrial Fibrillation; Award; Blood specimen; Cardiac Catheterization Procedures; Cardiac ablation; Cardiology; Cardiovascular Diseases; Cardiovascular system; Characteristics; Classification; Clinical; Clinical Data; Clinical Investigator; Clinical Management; Cluster Analysis; Coronary Arteriosclerosis; Data; Development; Doctor of Philosophy; Enrollment; Environment; Epidemiology; Etiology; Fellowship Program; Functional disorder; Funding; Genomics; Goals; Grant; Health Disparities Research; Heart Atrium; Heart failure; Heterogeneity; Hospitals; Image; Incidence; Individual; Ischemic Stroke; Knowledge; Lead; Life Style; Literature; Machine Learning; Master of Public Health; Mentors; Methodology; Multiomic Data; National Heart, Lung, and Blood Institute; Outcome; Participant; Patients; Pattern; Phenotype; Population; Prevention; Prevention strategy; Principal Investigator; Process; Public Health; Public Health Schools; Research; Research Activity; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Stratification; Stroke; Survival Analysis; Techniques; Technology; Therapeutic; Therapeutic Intervention; Time; Training; Training Programs; Universities; Work; base; biobank; candidate selection; cardiovascular disorder epidemiology; cardiovascular health; career development; clinical prognosis; graduate student; high risk population; innovation; interest; lifestyle factors; medical schools; metabolomics; mortality; multidisciplinary; multiple omics; novel; novel therapeutic intervention; patient oriented; patient oriented research; patient prognosis; patient registry; patient subsets; prevent; preventive intervention; programs; prospective; protein biomarkers; skill acquisition; skills; sociodemographic factors; sociodemographics; transcriptomics; trend

PROJECT SUMMARY This application will provide the Principal Investigator, Dr. Alvaro Alonso, with protected time and other support to (1) accelerate a successful record of mentoring junior clinical investigators and graduate students engaged in patient-oriented cardiovascular research; (2) obtain additional training in omics, machine learning, and mentoring best-practices; and (3) advance Dr. Alonso's ongoing research on the risk factors and mechanisms contributing to the development of atrial fibrillation (AF). Mentoring activities will build upon the ongoing involvement of Dr. Alonso in several training programs at Emory University, including an NHLBI-funded multidisciplinary T32 training grant on cardiovascular health disparities, the research-track Cardiology fellowship program at the School of Medicine, and the Master of Public Health and PhD programs in epidemiology at the Rollins School of Public Health. Training will focus on cutting-edge methodological areas in rapid development, including integration of omic technologies and machine learning in patient-oriented research, as well as acquisition of skills in academic, research, and clinical mentoring. Finally, this award will support a research project that extends Dr. Alonso's ongoing work on understanding the factors influencing the development of the AF substrate, understanding AF pathophysiology, and preventing AF-related outcomes. The specific aims of this research are: (1) to identify novel AF phenotypes (phenogroups) using extensive clinical and multi-omic data (“phenomapping”), (2) to discover specific risk factors for the different AF phenogroups, and (3) to determine associations of AF phenogroups with selected endpoints (stroke, heart failure, mortality). These research aims will be carried out in the context of the Emory Cardiovascular Biobank, an ongoing prospective registry of patients undergoing cardiac catheterization in three Emory-affiliated hospitals currently including approximately 7,000 unique individuals with detailed phenotyping, clinical outcomes, and multi-omic markers. In summary, the activities proposed in this application will favorably impact Dr. Alonso's capabilities to conduct cutting-edge and innovative patient-oriented research on cardiovascular prevention and his ability to perform as a highly qualified mentor for junior clinicians pursuing research on clinical cardiovascular epidemiology and prevention.

项目摘要 该申请将为主要研究人员Alvaro Alonso博士提供受保护的时间和其他支持 （1）加速了精神上的初级临床研究人员和研究生的成功记录 在面向患者的心血管研究中； （2）获得OMIC，机器学习和 指导最佳实践； （3）推进阿隆索博士对风险因素和机制的持续研究 有助于房颤的发展（AF）。指导活动将基于持续的 阿隆索博士参与埃默里大学的多项培训计划，包括NHLBI资助 心血管健康差异的多学科T32培训补助金，研究轨道心脏病学 医学院的奖学金计划，以及公共卫生和博士学位硕士课程 罗林斯公共卫生学院的流行病学。培训将重点放在尖端的方法论领域 快速发展，包括在以患者为导向的OMIC Technologies和机器学习的集成 研究，以及学术，研究和临床心理方面的技能。最后，这个奖项将 支持一个扩展Alonso博士正在进行的了解因素影响因素的研究项目 AF底物的发展，了解AF病理生理学并预防与AF相关的结果。 这项研究的具体目的是：（1）使用广泛的 临床和多族数据（“现象”），（2）发现不同AF的特定风险因素 现象群，（3）确定AF现象与选定端点的关联（卒中，心脏 失败，死亡率）。这些研究目标将在埃默里心血管生物库的背景下进行 持续的前瞻性注册表，即在三个埃默里附上进行心脏导管插入术的患者 目前，医院包括大约7,000名独特的人，具有详细的表型，临床 结果和多摩尼克标记。总而言之，本申请中提出的活动将有利地影响 阿隆索博士对心血管进行最先进和创新的以患者为导向的研究 预防及其作为初级临床医生的高素质精神的能力，从事研究 临床心血管流行病学和预防。