Smooth Muscle Plasticity: A COBRE

平滑肌可塑性：COBRE

• 批准号: 8139527
• 负责人: KENTON M SANDERS
• 金额: $ 17.7万
• 依托单位: UNIVERSITY OF NEVADA RENO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-23 至 2011-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8139527
• 关键词: Advisory Committees; Alabama; Area; Arts; Australia; Award; Back; Biochemistry; Biological Models; Biology; Biomedical Research; Cellular Morphology; Cellular biology; Center for Translational Science Activities; Centers of Research Excellence; Commit; Computers; Core Facility; Country; Dedications; Defect; Development; Development Plans; Disease model; Equipment; Evaluation; Faculty; Functional disorder; Funding; Funding Opportunities; Gene Targeting; Goals; Grant; Head; Health Sciences; Human Resources; Hypertrophy; Image; Institution; International; Laboratories; Leadership; Learning; Link; Mechanics; Mentors; MicroRNAs; Molecular; Molecular Biology; Molecular Medicine; Motor; Muscle; National Center for Research Resources; Nevada; Overactive Bladder; Peer Review; Pharmacology; Phase; Phenotype; Physiology; Positioning Attribute; Postdoctoral Fellow; Potassium Channel; Program Research Project Grants; Publications; Qualifying; Quality Control; Recruitment Activity; Regulation; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Schools; Scientist; Smooth Muscle; Solid; Specialist; Stimulus; Stretching; Students; Training; Transgenic Organisms; United States National Institutes of Health; Universities; Work; calmodulin-dependent protein kinase II; career; career development; citrate carrier; clinically relevant; diabetic gastroparesis; experience; falls; graduate student; in vitro Model; laboratory facility; lecturer; medical schools; meetings; member; muscle hypertrophy; new technology; professor; programs; protein expression; public health relevance; research and development; response; square foot; success; symposium

DESCRIPTION (provided by applicant): This proposal is to renew funding for the Smooth Muscle Plasticity Center of Biomedical Research Excellence (COBRE) at the University of Nevada, Reno (UNR). The COBRE has expanded the research infrastructure and helped to develop the careers of several highly promising young investigators. The center has a strong thematic focus in smooth muscle biology. The COBRE consists of 5 projects that are investigating various aspects of smooth muscle plasticity. Project 1: Correlation between structural and motor defects in diabetic gastroparesis to be headed by Dr. Grant Hennig; Project 2: Phopholamban and CaM Kinase II in smooth muscle plasticity to be headed by Dr. Brian Perrino; Project 3: An in vitro model system for determining regulatory mechanisms for smooth muscle mechanics to be led by Dr. Josh Baker; Project 4: Smooth muscle hypertrophy regulated by microRNAs and their target genes to be headed by Dr. Seungil Ro; Project 5: Stretch-dependent potassium channel regulation in overactive bladder to be led by Dr. Sang Don Koh. The projects are supported by Core lab facilities: Core A: Administration and faculty development; Core B: Molecular expression and transgenics; Core C: Protein expression and cell morphology; and Core D: Dynamic imaging. The COBRE will be administered by: i) the Central COBRE Administration consisting of the PI and Co-PI, administrative assistant and computer specialist; ii) an Internal Advisory Committee (lAC) with mentors for each project leader; and iii) an External Advisory Committee (EAC) consisting of leaders in smooth muscle biology. Mentors in the lAC are distinguished scientists with productive careers in biomedical research. The lAC establishes milestones for career development, performs formative and summative evaluation of progress toward milestones, and assists the Project Leaders in the central goal of developing independent funding and sustainable research careers. The COBRE is led by Drs. Kenton Sanders and Christine Cremo as PI and Co-PI, respectively. The PI and Co-PI are highly qualified, with many years of administrative and scientific experience in the thematic focus of the COBRE. PUBLIC HEALTH RELEVANCE (provided by applicant): Smooth muscles are unique among muscle lineages because they change phenotype in response to a variety of stimuli. Pathophysiological conditions result from phenotypic changes in smooth muscle tissues, but the cause and consequences of remodeling and hypertrophy are not well understood. Several disease models of smooth muscles will be used to learn how phenotypic change contributes to pathophysiology.

描述（由申请人提供）：该提案是为了为内华达大学里诺大学（UNR）的生物医学研究卓越生物医学研究（Cobre）的平滑肌可塑性中心（UNR）续签。该鞋底扩大了研究基础设施，并帮助发展了几位高度有前途的年轻研究者的职业。该中心在平滑肌生物学上具有强烈的主题重点。该鞋底由5个项目组成，这些项目正在研究平滑肌可塑性的各个方面。项目1：由Grant Hennig博士领导的糖尿病性胃轻瘫的结构和运动缺陷之间的相关性；项目2：Phopholamban和CAM激酶II在平滑肌可塑性中由Brian Perrino博士领导；项目3：一种体外模型系统，用于确定由Josh Baker博士领导的平滑肌力学的调节机制；项目4：由MicroRNA调节的平滑肌肥大及其靶基因由Seungil Ro博士领导；项目5：由Sang Don Koh博士领导的过度活跃膀胱中的伸展依赖性钾通道调节。这些项目得到了核心实验室设施的支持：核心A：行政和教师发展；核心B：分子表达和转基因； Core C：蛋白质表达和细胞形态；和核心D：动态成像。毛绒将由：i）由PI和Co-Pi，行政助理和计算机专家组成的中央毛线管理； ii）一个内部咨询委员会（LAC），为每个项目负责人提供导师； iii）由平滑肌生物学领导者组成的外部咨询委员会（EAC）。 LAC中的导师是杰出的科学家，从事生物医学研究的生产力。 LAC为职业发展建立了里程碑，对对里程碑的进步进行了形成性和总结性评估，并协助项目领导者制定了建立独立资金和可持续研究职业的核心目标。毛绒由Drs领导。 Kenton Sanders和Christine Cremo分别为PI和Co-Pi。 PI和Co-Pi具有很高的资格，在Cobre的主题重点方面拥有多年的行政和科学经验。 公共卫生相关性（由申请人提供）：平滑肌肉在肌肉谱系中是独一无二的，因为它们会因各种刺激而改变表型。病理生理状况是由平滑肌组织的表型变化导致的，但是重塑和肥大的原因和后果尚不清楚。几种光滑肌肉的疾病模型将用于学习表型变化如何对病理生理有效。