Smooth Muscle Plasticity: A COBRE

平滑肌可塑性：COBRE

• 批准号: 8139527
• 负责人: KENTON M SANDERS
• 金额: $ 17.7万
• 依托单位: UNIVERSITY OF NEVADA RENO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-23 至 2011-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8139527
• 关键词: Advisory Committees; Alabama; Area; Arts; Australia; Award; Back; Biochemistry; Biological Models; Biology; Biomedical Research; Cellular Morphology; Cellular biology; Center for Translational Science Activities; Centers of Research Excellence; Commit; Computers; Core Facility; Country; Dedications; Defect; Development; Development Plans; Disease model; Equipment; Evaluation; Faculty; Functional disorder; Funding; Funding Opportunities; Gene Targeting; Goals; Grant; Head; Health Sciences; Human Resources; Hypertrophy; Image; Institution; International; Laboratories; Leadership; Learning; Link; Mechanics; Mentors; MicroRNAs; Molecular; Molecular Biology; Molecular Medicine; Motor; Muscle; National Center for Research Resources; Nevada; Overactive Bladder; Peer Review; Pharmacology; Phase; Phenotype; Physiology; Positioning Attribute; Postdoctoral Fellow; Potassium Channel; Program Research Project Grants; Publications; Qualifying; Quality Control; Recruitment Activity; Regulation; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Schools; Scientist; Smooth Muscle; Solid; Specialist; Stimulus; Stretching; Students; Training; Transgenic Organisms; United States National Institutes of Health; Universities; Work; calmodulin-dependent protein kinase II; career; career development; citrate carrier; clinically relevant; diabetic gastroparesis; experience; falls; graduate student; in vitro Model; laboratory facility; lecturer; medical schools; meetings; member; muscle hypertrophy; new technology; professor; programs; protein expression; public health relevance; research and development; response; square foot; success; symposium

DESCRIPTION (provided by applicant): This proposal is to renew funding for the Smooth Muscle Plasticity Center of Biomedical Research Excellence (COBRE) at the University of Nevada, Reno (UNR). The COBRE has expanded the research infrastructure and helped to develop the careers of several highly promising young investigators. The center has a strong thematic focus in smooth muscle biology. The COBRE consists of 5 projects that are investigating various aspects of smooth muscle plasticity. Project 1: Correlation between structural and motor defects in diabetic gastroparesis to be headed by Dr. Grant Hennig; Project 2: Phopholamban and CaM Kinase II in smooth muscle plasticity to be headed by Dr. Brian Perrino; Project 3: An in vitro model system for determining regulatory mechanisms for smooth muscle mechanics to be led by Dr. Josh Baker; Project 4: Smooth muscle hypertrophy regulated by microRNAs and their target genes to be headed by Dr. Seungil Ro; Project 5: Stretch-dependent potassium channel regulation in overactive bladder to be led by Dr. Sang Don Koh. The projects are supported by Core lab facilities: Core A: Administration and faculty development; Core B: Molecular expression and transgenics; Core C: Protein expression and cell morphology; and Core D: Dynamic imaging. The COBRE will be administered by: i) the Central COBRE Administration consisting of the PI and Co-PI, administrative assistant and computer specialist; ii) an Internal Advisory Committee (lAC) with mentors for each project leader; and iii) an External Advisory Committee (EAC) consisting of leaders in smooth muscle biology. Mentors in the lAC are distinguished scientists with productive careers in biomedical research. The lAC establishes milestones for career development, performs formative and summative evaluation of progress toward milestones, and assists the Project Leaders in the central goal of developing independent funding and sustainable research careers. The COBRE is led by Drs. Kenton Sanders and Christine Cremo as PI and Co-PI, respectively. The PI and Co-PI are highly qualified, with many years of administrative and scientific experience in the thematic focus of the COBRE. PUBLIC HEALTH RELEVANCE (provided by applicant): Smooth muscles are unique among muscle lineages because they change phenotype in response to a variety of stimuli. Pathophysiological conditions result from phenotypic changes in smooth muscle tissues, but the cause and consequences of remodeling and hypertrophy are not well understood. Several disease models of smooth muscles will be used to learn how phenotypic change contributes to pathophysiology.

描述（由申请人提供）：本提案旨在为内华达大学里诺分校 (UNR) 的平滑肌可塑性生物医学卓越研究中心 (COBRE) 续订资金。 COBRE 扩大了研究基础设施，并帮助发展了几位非常有前途的年轻研究人员的职业生涯。该中心的主题重点是平滑肌生物学。 COBRE 由 5 个项目组成，正在研究平滑肌可塑性的各个方面。项目 1：糖尿病性胃轻瘫结构性和运动性缺陷之间的相关性，由 Grant Hennig 博士领导；项目 2：Phopholamban 和 CaM 激酶 II 在平滑肌可塑性方面的作用，由 Brian Perrino 博士领导；项目3：确定平滑肌力学调节机制的体外模型系统，由Josh Baker博士领导；项目4：microRNA及其靶基因调节平滑肌肥大，由Seungil Ro博士领导；项目 5：膀胱过度活动症的拉伸依赖性钾通道调节，由 Sang Don Koh 博士领导。这些项目由核心实验室设施支持： 核心 A：管理和教师发展；核心B：分子表达和转基因；核心C：蛋白质表达和细胞形态；核心D：动态成像。 COBRE 将由以下人员管理： i) COBRE 中央管理部门，由 PI 和 Co-PI、行政助理和计算机专家组成； ii) 内部咨询委员会 (LAC)，每个项目负责人都有导师； iii) 由平滑肌生物学领域的领导者组成的外部咨询委员会 (EAC)。 LAC 的导师都是在生物医学研究领域取得丰硕成果的杰出科学家。 LAC 建立职业发展的里程碑，对里程碑的进展进行形成性和总结性评估，并协助项目负责人实现发展独立资助和可持续研究职业的中心目标。 COBRE 由博士领导。 Kenton Sanders 和 Christine Cremo 分别担任 PI 和 Co-PI。 PI 和 Co-PI 资质很高，在 COBRE 的主题重点方面拥有多年的管理和科学经验。 公共卫生相关性（由申请人提供）：平滑肌在肌肉谱系中是独一无二的，因为它们会根据各种刺激而改变表型。病理生理状况是由平滑肌组织的表型变化引起的，但重塑和肥大的原因和后果尚不清楚。几种平滑肌疾病模型将用于了解表型变化如何影响病理生理学。