Effects of Transcranial Magnetic Stimulation on Neurons in Behaving Primates
经颅磁刺激对行为灵长类动物神经元的影响
基本信息
- 批准号:8412767
- 负责人:
- 金额:$ 15.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-07-01 至 2014-06-30
- 项目状态:已结题
- 来源:
- 关键词:Action PotentialsAffectAreaAxonBasic ScienceBehaviorBehavioralBiomedical EngineeringBrainCerebral cortexCerebrumCognitionComplementCustomDataDistantElectronicsFelis catusGenerationsGoalsHeadHumanInterneuronsKnowledgeLaboratoriesLateralLocationMagnetismMapsMeasuresMental disordersMethodsModelingMonkeysMorphologic artifactsMovementNeurologicNeuronsOutcomePhotic StimulationPhysiologic pulsePhysiologicalPrimatesProtocols documentationPyramidal CellsResearch PersonnelRestRiskSensory ProcessSeriesSiteTechniquesTestingTherapeuticTherapeutic InterventionTimeTranscranial magnetic stimulationVariantVisionVisualWorkarea V1area striataawakebasedesignfrontal eye fieldshippocampal pyramidal neuronimprovedin vivoinnovationmagnetic fieldmotor disordernervous system disorderneuronal cell bodyneurophysiologynonhuman primateoculomotorresearch studytoolvisual control
项目摘要
Transcranial magnetic stimulation (TMS) is a non-invasive method for stimulating the human brain. It
has contributed greatly to our understanding of normal brain function and shows promise in therapies
for psychiatric and neurological disorders. Exactly what TMS does to neuronal activity, however,
remains unknown. We will apply single pulses of TMS while recording from single neurons in
behaving non-human primates. Our TMS methods will correspond to those used in humans and will
be easily adoptable by any primate neurophysiology laboratory. A team of researchers will design
custom TMS coils to direct the focus of stimulation to precise locations of cerebral cortex, innovative
electronics to permit neuronal recordings within 1 ms after TMS pulses, and controlled visual-
oculomotor tasks to allow systematic variation of behavioral and thus neuronal state. We will record
from single neurons and field potentials at both the site of stimulation and at distant but
monosynaptically connected sites. The end result of our work will be to discover how TMS influences
the brain at the level of single neurons and simple circuits. Implications will include improved,
physiologically-guided TMS protocols for human basic research studies and therapeutic applications.
经颅磁刺激(TMS)是一种非侵入性的刺激人脑的方法。它
极大地促进了我们对正常大脑功能的理解,
治疗精神和神经疾病然而,TMS对神经元活动的作用,
仍然未知。我们将应用TMS的单脉冲,同时记录单个神经元,
非人类灵长类动物的行为我们的TMS方法将与人类使用的方法相对应,
任何灵长类动物神经生理学实验室都能轻易采用。一组研究人员将设计
定制TMS线圈,将刺激焦点引导到大脑皮层的精确位置,
电子设备允许在TMS脉冲后1 ms内进行神经元记录,并控制视觉-
视觉任务允许行为和神经元状态的系统变化。我们将记录
从单个神经元和场电位在刺激的网站和在遥远的,但
单突触连接的部位。我们工作的最终结果将是发现TMS如何影响
在单个神经元和简单回路的水平上研究大脑。影响将包括改进,
用于人类基础研究和治疗应用的生理学指导的TMS方案。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Marc A Sommer其他文献
The feeling of looking
看的感觉
- DOI:
10.1038/nn0507-538 - 发表时间:
2007-05-01 - 期刊:
- 影响因子:20.000
- 作者:
Marc A Sommer - 通讯作者:
Marc A Sommer
Marc A Sommer的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Marc A Sommer', 18)}}的其他基金
Enhancement, mapping, and validation of viral vectors for primate optogenetics
用于灵长类光遗传学的病毒载体的增强、绘图和验证
- 批准号:
10391957 - 财政年份:2022
- 资助金额:
$ 15.15万 - 项目类别:
Enhancement, mapping, and validation of viral vectors for primate optogenetics
用于灵长类光遗传学的病毒载体的增强、绘图和验证
- 批准号:
10546445 - 财政年份:2022
- 资助金额:
$ 15.15万 - 项目类别:
Neuromuscular Control of Primate Eye Movements
灵长类动物眼球运动的神经肌肉控制
- 批准号:
9919573 - 财政年份:2019
- 资助金额:
$ 15.15万 - 项目类别:
2017 Eye Movements Gordon Research Conference and Gordon Research Seminar
2017眼动戈登研究会议暨戈登研究研讨会
- 批准号:
9331202 - 财政年份:2017
- 资助金额:
$ 15.15万 - 项目类别:
Impact of Timing, Targeting, and Brain State on rTMS of Human and Non-Human Primates
时间、目标和大脑状态对人类和非人类灵长类动物 rTMS 的影响
- 批准号:
9390539 - 财政年份:2017
- 资助金额:
$ 15.15万 - 项目类别:
Effects of Transcranial Magnetic Stimulation on Neurons in Behaving Primates
经颅磁刺激对行为灵长类动物神经元的影响
- 批准号:
8285060 - 财政年份:2012
- 资助金额:
$ 15.15万 - 项目类别:
Functions of Saccadic Circuits in Lateral Cerebellar Cortex
小脑外侧皮层扫视回路的功能
- 批准号:
8523897 - 财政年份:2012
- 资助金额:
$ 15.15万 - 项目类别:
Functions of Saccadic Circuits in Lateral Cerebellar Cortex
小脑外侧皮层扫视回路的功能
- 批准号:
8359944 - 财政年份:2012
- 资助金额:
$ 15.15万 - 项目类别:
Visuomotor functions of ascending pathways to frontal cortex
额叶皮层上升通路的视觉运动功能
- 批准号:
7908752 - 财政年份:2006
- 资助金额:
$ 15.15万 - 项目类别:
Visuomotor functions of ascending pathways to frontal cortex
额叶皮层上升通路的视觉运动功能
- 批准号:
7130992 - 财政年份:2006
- 资助金额:
$ 15.15万 - 项目类别:
相似海外基金
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 15.15万 - 项目类别:
Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 15.15万 - 项目类别:
Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 15.15万 - 项目类别:
Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 15.15万 - 项目类别:
Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 15.15万 - 项目类别:
Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 15.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 15.15万 - 项目类别:
Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 15.15万 - 项目类别:
Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
- 批准号:
23K00129 - 财政年份:2023
- 资助金额:
$ 15.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
- 批准号:
2883985 - 财政年份:2023
- 资助金额:
$ 15.15万 - 项目类别:
Studentship