Functions of Saccadic Circuits in Lateral Cerebellar Cortex
小脑外侧皮层扫视回路的功能
基本信息
- 批准号:8359944
- 负责人:
- 金额:$ 21.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-01 至 2014-08-31
- 项目状态:已结题
- 来源:
- 关键词:Action PotentialsAffectAnatomyAnimalsAreaBehaviorBehavioralBrainCellsCerebellar DiseasesCerebellar cortex structureCerebellumCerebral cortexCerebrumCognitionCognitiveComplexDataDentate nucleusDiseaseDorsalExhibitsEyeFiberFoundationsFutureGoalsGolgi ApparatusHistologicImageIndiumInferiorInterneuronsKnowledgeLateralLeadLesionMacacaMagnetic Resonance ImagingMapsMediatingMonkeysMotorMovementNeuroanatomyNeuronsOlives - dietaryOutcomeOutputParietalPatternPhysiologicalPlayPontine structurePrimatesProcessPublishingPurkinje CellsRestRoleSaccadesShapesSideSignal TransductionSiteStructureStructure-Activity RelationshipSurveysTestingTextbooksTimeTracerWorkbasecell typedesignexecutive functionfollow-upgranule cellimprovedinhibitory neuroninsightkinematicsmossy fibermotor controlmotor learningneuroimagingneurophysiologyneuropsychiatrynoveloperation
项目摘要
DESCRIPTION (provided by applicant): The cerebellum is a crucial brain structure for the control of movement. Recent data from lesion studies, neuroimaging, and neuroanatomy also implicate its lateral portion in non-motor functions, including cognitive processes. The lateral cerebellum may participate in such functions through its closed-loop connections with prefrontal and parietal cerebral cortex. A critical segment of these loops involves circuitry within the laterl cerebellum itself, extending through its cortical mantle to the dentate nucleus. Essentially nothing is known about non-motor signals in these intracerebellar circuits. We will record the signals directly in macaque monkeys that perform tasks involving cognitive demands such as self-timing of behavior. The studies are challenging because the cerebellar cortex, even just its lateral portion, is vast. Moreover it is highly foliated and deep in the brain, making it difficultto survey neurophysiologically. Efficient and systematic neurophysiology can now be achieved, however, based on recently available neuroanatomical maps that detail the motor and non- motor domains of cerebellar cortex. Our first aim is to record from neurons in two restricted zones of lateral cerebellar cortex known to be functionally connected with prefrontal and parietal cerebral cortex. The recording zones will be targeted using structural MRIs of each monkey's cerebellum referenced to published connectivity maps. During recordings, we will use physiological criteria to identify signals conveyed at three functional levels: cerebellar cortical
output (Purkinje cells), input (mossy and climbing fibers), and local processing (Golgi cells). Our
second aim provides for a definitive follow-up by comparing our recording sites with histologically documented cerebellar circuits in the same animals. This anatomical conclusion is crucial for interpreting the results of the first aim and for informing the strategies of future studies. The end result of this project will be a systematic description of both the non-motor and motor information conveyed within physiologically identified, and anatomically confirmed, circuits of the lateral cerebellum. The broader outcomes will be to improve our understanding of how the cerebellum helps to mediate cognition and to provide a novel functional perspective on the relation between cerebellar dysfunction and neuropsychiatric disorders.
PUBLIC HEALTH RELEVANCE: It is textbook knowledge that the cerebellum contributes to motor learning and coordination, but recent evidence from imaging, anatomy, and lesion studies implicate it, as well, in non-motor functions such as cognition. Our work will analyze the information conveyed within microcircuits of the cerebellum in monkeys that perform both motor and non-motor tasks. The results will provide a circuit-level description of cerebellar participatin in non-motor functions and new insights into the association between cerebellar dysfunction and neuropsychiatric disorders.
描述(申请人提供):小脑是控制运动的重要大脑结构。来自病变研究、神经影像学和神经解剖学的最新数据也表明其外侧部分参与非运动功能,包括认知过程。外侧小脑可能通过其与前额叶和顶叶大脑皮层的闭环连接参与这些功能。这些回路的一个关键部分涉及小脑外侧本身的回路,通过其皮层地幔延伸到齿状核。基本上,我们对这些小脑内回路中的非运动信号一无所知。我们将直接记录猕猴在执行涉及认知需求的任务时的信号,比如行为的自我定时。这些研究具有挑战性,因为小脑皮层,甚至只是它的外侧部分,是巨大的。此外,它是高度叶状的,位于大脑深处,因此很难从神经生理学上进行调查。然而,基于最近可用的详细描述小脑皮层运动和非运动区域的神经解剖图谱,现在可以实现有效和系统的神经生理学。我们的第一个目标是记录来自外侧小脑皮层的两个限制区域的神经元,已知这些区域与前额叶和顶叶大脑皮层有功能联系。记录区域将使用每只猴子小脑的结构核磁共振成像,参照已公布的连接图进行定位。在录音过程中,我们将使用生理标准来识别在三个功能水平上传递的信号:小脑皮质
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Marc A Sommer其他文献
The feeling of looking
看的感觉
- DOI:
10.1038/nn0507-538 - 发表时间:
2007-05-01 - 期刊:
- 影响因子:20.000
- 作者:
Marc A Sommer - 通讯作者:
Marc A Sommer
Marc A Sommer的其他文献
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{{ truncateString('Marc A Sommer', 18)}}的其他基金
Enhancement, mapping, and validation of viral vectors for primate optogenetics
用于灵长类光遗传学的病毒载体的增强、绘图和验证
- 批准号:
10391957 - 财政年份:2022
- 资助金额:
$ 21.11万 - 项目类别:
Enhancement, mapping, and validation of viral vectors for primate optogenetics
用于灵长类光遗传学的病毒载体的增强、绘图和验证
- 批准号:
10546445 - 财政年份:2022
- 资助金额:
$ 21.11万 - 项目类别:
Neuromuscular Control of Primate Eye Movements
灵长类动物眼球运动的神经肌肉控制
- 批准号:
9919573 - 财政年份:2019
- 资助金额:
$ 21.11万 - 项目类别:
2017 Eye Movements Gordon Research Conference and Gordon Research Seminar
2017眼动戈登研究会议暨戈登研究研讨会
- 批准号:
9331202 - 财政年份:2017
- 资助金额:
$ 21.11万 - 项目类别:
Impact of Timing, Targeting, and Brain State on rTMS of Human and Non-Human Primates
时间、目标和大脑状态对人类和非人类灵长类动物 rTMS 的影响
- 批准号:
9390539 - 财政年份:2017
- 资助金额:
$ 21.11万 - 项目类别:
Effects of Transcranial Magnetic Stimulation on Neurons in Behaving Primates
经颅磁刺激对行为灵长类动物神经元的影响
- 批准号:
8285060 - 财政年份:2012
- 资助金额:
$ 21.11万 - 项目类别:
Functions of Saccadic Circuits in Lateral Cerebellar Cortex
小脑外侧皮层扫视回路的功能
- 批准号:
8523897 - 财政年份:2012
- 资助金额:
$ 21.11万 - 项目类别:
Effects of Transcranial Magnetic Stimulation on Neurons in Behaving Primates
经颅磁刺激对行为灵长类动物神经元的影响
- 批准号:
8412767 - 财政年份:2012
- 资助金额:
$ 21.11万 - 项目类别:
Visuomotor functions of ascending pathways to frontal cortex
额叶皮层上升通路的视觉运动功能
- 批准号:
7908752 - 财政年份:2006
- 资助金额:
$ 21.11万 - 项目类别:
Visuomotor functions of ascending pathways to frontal cortex
额叶皮层上升通路的视觉运动功能
- 批准号:
7130992 - 财政年份:2006
- 资助金额:
$ 21.11万 - 项目类别:
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