Collaborative RNAi

协同RNAi

基本信息

批准号：
8469424
负责人：
STEPHANIE E MOHR
金额：
$ 17.2万
依托单位：
DANA-FARBER CANCER INST
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8469424
关键词：
Address Adopted Area Biological Biological Assay Biology Cancer Biology Cancer Center Cancer Center Support Grant Categories Cell Death Cell Lineage Cell division Cells Complex Dana-Farber Cancer Institute Data Quality Data Set Development Doctor of Philosophy Drosophila genus Gene Expression Gene Targeting Genes Genetic Transcription Growth Instruction Interphase Cell Investigation Ions Lead Learning Libraries Link Malignant Neoplasms Mammalian Cell Messenger RNA Methods Molecular Molecular Biology Pathway interactions Phenotype RNA Interference Reagent Research Research Personnel Resource Sharing Screening Result Services Technology Tumor Suppressor Genes Validation Viral Vector anticancer research base cancer cell cancer genome cancer prevention cancer therapy cell growth gene function instrument meetings member operation screening small hairpin RNA tool tumor progression

项目摘要

PROJECT SUMM/\RY (See instructions): Understanding the basic biological mechanisms that underlie the development and progression of cancer is fundamental to finding better approaches to cancer prevention and treatment. High-throughput RNA interference (RNAi) screening is a state-of-the-art method for large-scale investigation of gene function, including identification of new cancer-related genes and pathways. The Collaborative RNAi Core offers a single portal through which DF/HCC members are educated about the use of RNAi screening and resulting datasets to study cancer biology, learn about specific screening options to meet their research needs and access RNAi facilities that had not been consistently available to Cancer Center members. The Core also coordinates the operations and administrative functions of these primarily independent RNAi units. This Core was created during the project period due to high member demand and is presented as a new Established Shared Resource in this proposal. Director: Stephanie Mohr, PhD(HMS) Category: 1.20 (Molecular Biology) and 1.37 (RNAi Screening)

项目summ/\ ry（请参阅说明）：了解癌症发展和进展的基本生物学机制对于寻找更好的预防癌症和治疗方法至关重要。高通量RNA干扰（RNAI）筛选是对基因功能进行大规模研究的最新方法，包括鉴定与癌症相关的新基因和途径。协作RNAi Core提供了一个门户网站，通过该门户将DF/HCC成员通过该门户提供有关使用RNAI筛查的使用以及由此导致的数据集研究癌症生物学的，了解特定的筛查选项，以满足其研究需求，并访问癌症中心成员始终可用的RNAI设施。核心还协调这些主要独立RNAi单元的操作和行政功能。该核心是由于成员需求较高而在项目期间创建的，并作为本提案中的新的共享资源呈现。导演：Stephanie Mohr博士（HMS）类别：1.20（分子生物学）和1.37（RNAi筛选）