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Collaborative RNAi

协同RNAi

基本信息

批准号：
8469424
负责人：
STEPHANIE E MOHR
金额：
$ 17.2万
依托单位：
DANA-FARBER CANCER INST
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8469424
关键词：
Address Adopted Area Biological Biological Assay Biology Cancer Biology Cancer Center Cancer Center Support Grant Categories Cell Death Cell Lineage Cell division Cells Complex Dana-Farber Cancer Institute Data Quality Data Set Development Doctor of Philosophy Drosophila genus Gene Expression Gene Targeting Genes Genetic Transcription Growth Instruction Interphase Cell Investigation Ions Lead Learning Libraries Link Malignant Neoplasms Mammalian Cell Messenger RNA Methods Molecular Molecular Biology Pathway interactions Phenotype RNA Interference Reagent Research Research Personnel Resource Sharing Screening Result Services Technology Tumor Suppressor Genes Validation Viral Vector anticancer research base cancer cell cancer genome cancer prevention cancer therapy cell growth gene function instrument meetings member operation screening small hairpin RNA tool tumor progression

项目摘要

PROJECT SUMM/\RY (See instructions): Understanding the basic biological mechanisms that underlie the development and progression of cancer is fundamental to finding better approaches to cancer prevention and treatment. High-throughput RNA interference (RNAi) screening is a state-of-the-art method for large-scale investigation of gene function, including identification of new cancer-related genes and pathways. The Collaborative RNAi Core offers a single portal through which DF/HCC members are educated about the use of RNAi screening and resulting datasets to study cancer biology, learn about specific screening options to meet their research needs and access RNAi facilities that had not been consistently available to Cancer Center members. The Core also coordinates the operations and administrative functions of these primarily independent RNAi units. This Core was created during the project period due to high member demand and is presented as a new Established Shared Resource in this proposal. Director: Stephanie Mohr, PhD(HMS) Category: 1.20 (Molecular Biology) and 1.37 (RNAi Screening)

项目总和/\RY（参见说明）：了解癌症发展和进展的基本生物学机制是找到更好的癌症预防和治疗方法的基础。高通量RNA干扰（RNAi）筛选是一种用于大规模研究基因功能的最先进方法，包括鉴定新的癌症相关基因和途径。协作RNAi核心提供了一个单一的门户网站，通过该门户网站，DF/HCC成员可以了解使用RNAi筛查和由此产生的数据集来研究癌症生物学，了解特定的筛查选项以满足他们的研究需求，并访问癌症中心成员无法持续使用的RNAi设施。核心还协调这些主要独立的RNAi单位的运作和行政职能。此核心是在项目期间由于成员需求高而创建的，在本提案中作为新的既定共享资源呈现。主任：Stephanie Mohr，PhD（HMS）类别：1.20（分子生物学）和1.37（RNAi筛选）