Shared Resource 05: Collaborative Functional Genomics

功能基因组学协作共享资源 项目总结/摘要 了解癌症发展和进展的基本生物学机制， 这是找到更好的癌症预防和治疗方法的基础。功能丧失遗传 方法，如高通量RNA干扰（RNAi）和CRISPR/Cas9，以及功能获得 诸如开放阅读框（ORF）过表达和CRISPR-活化（CRISPR-a）的方法提供了 确定新的癌症相关基因和途径的尖端策略。合作功能 Genomics Core提供了一个单一的门户网站，DF/HCC成员可以通过该门户网站获得技术、试剂 服务和科学咨询。核心使命是支持尽可能广泛的功能 基因组学筛选项目;迅速传播关于新的功能基因组学方法的信息;以及 帮助研究人员从概念和检测开发到高通量筛选、分析， 验证。

Collaborative Functional Genomics Shared Resource Project Summary / Abstract Understanding the basic biological mechanisms that underlie the development and progression of cancer is fundamental to finding better approaches to cancer prevention and treatment. Loss-of-function genetic approaches, such as high-throughput RNA interference (RNAi) and CRISPR/Cas9, as well as gain-of-function approaches such as open reading frame (ORF) over-expression and CRISPR-activation (CRISPR-a) provide cutting-edge strategies to identify new cancer-related genes and pathways. The Collaborative Functional Genomics Core offers a single portal through which DF/HCC members gain access to technologies, reagents, services, and scientific consultation. The Core mission is to support the widest possible range of functional genomics screening projects; rapidly disseminate information about new functional genomics approaches; and help researchers navigate from concept and assay development to high-throughput screening, analysis, and validation.