Research Training in Pediatric Endocrinology

描述（由申请人提供）：本申请是匹兹堡大学（UOP）儿科系UPMC匹兹堡儿童医院（CHP）儿科内分泌学和糖尿病博士后研究培训的竞争性更新。这个为期14年的研究培训计划的目标是提供最先进的培训，在分子，细胞，生理，遗传，儿科内分泌学的生化或流行病学方面，以确保医生-从该计划毕业的科学家为与他们选择的儿科内分泌学和糖尿病的任何方面相关的转化研究的富有成效的学术生涯做好了充分的准备，大学里的辅导专家这个著名的长期建立的奖学金计划的大多数毕业生都在全职学术职位与许多研究领导职位，该计划需要两到三年的指导研究（基础科学或临床）除了奖学金培训的法定临床年。儿科内分泌学和糖尿病部的教师有不同的兴趣，是积极的研究者，其中大部分是赠款资助，并与UOP和卡内基梅隆大学的其他教师和组件广泛互动。虽然临床培训围绕着卫生防护中心的儿科内分泌学，糖尿病和肥胖科进行，但随后的研究年将由研究员从该部门内外的研究导师名单中选择的主要导师监督，这取决于研究员的兴趣。所有研究教师导师都是既定的调查员，因为他们的研究的直接翻译相关性和高素质，他们的培训医学博士的杰出记录而被选中。和博士科学家，他们的长期生产力和成功地获得校外资金，以及他们对跨学科项目的兴趣。除了一个主要的研究导师，每个学员将由导师委员会，包括项目主任，监督和评估他/她的科学进步和职业发展的监督。受训者将与其他医学博士并肩工作，哲学博士、医学博士/博士博士前或博士后学员。定期评估，再加上正式的课程工作，将提供一个严格的知识基础，为每个学员的科学努力。卫生防护中心和医学院对儿科研究的机构承诺是实质性的。UPMC和CHP承诺在未来3年内每年提供750万美元，包括2008年12月开放的最先进的儿科研究大楼。因此，该计划的整体成就，其关键的知识质量，以及CHP和UOP的巨大资源，使其成为一个优秀的计划，以培养急需的儿科内分泌医生科学家，鼓励他们过渡到K奖，并培养他们作为独立的R 01资助的研究人员的成功。随着国家对儿科内分泌学的兴趣越来越大，正如申请人的数量所反映的那样，我们预计这项研究培训计划将提供一种机制，通过这种机制，当代医生-科学家将获得成功和富有成效的转化研究学术生涯的基本工具。相关性（参见说明）：这个儿科内分泌和糖尿病培训计划，由T-32资助，在过去的14年里，已经产生了一个国家和国际公认的儿科内分泌研究人员的干部，包括6个儿科主席，9个部门负责人和2个劳森威尔金斯儿科内分泌学会主席。因此，我们的项目传统上一直是美国儿科内分泌学家的主要提供者。该计划是仅有的16个NIDDK资助的儿科内分泌/糖尿病培训赠款之一，其毕业生对该子专业的学术未来至关重要。

DESCRIPTION (provided by applicant): This application is for the competitive renewal of the post-doctoral research training pediatric endocrinology and diabetes at the Children's Hospital of Pittsburgh (CHP) of UPMC, Department of Pediatrics, University of Pittsburgh (UOP). The goal of this 14 year research training program is to provide state-of-the- art training in the molecular, cellular, physiologic, genetic, biochemical or epidemiologic aspects of pediatric endocrinology to ensure that the physician-scientists who graduate from this program are well prepared for productive academic careers in translational research related to their choice of any aspect of pediatric endocrinology and diabetes for which there is mentorship expertise at the university. The majority of graduates of this well known long established fellowship program are in full-time academic positions with many in research leadership positions, The program entails two to three years of mentored research (basic science or clinical) in addition to the mandated clinical year of fellowship training. The faculty of the Division of Pediatric Endocrinology and Diabetes has diverse interests, are active investigators, most of whom are grant funded, and are widely interactive with other faculty and components of the UOP and Carnegie Mellon University. While clinical training revolves around the Division of Pediatric Endocrinology, Diabetes, and Obesity at the CHP, subsequent research years will be supervised by a primary mentor selected by the fellow from the research mentor list within or outside the division, depending on the interest of the fellow. All Research Faculty Mentors are established investigators, selected because of the immediate translational relevance and high caliber of their research, their outstanding records of training M.D. and Ph.D. scientists, their long-term productivity and success in securing extramural funding, and their interest in interdisciplinary projects. In addition to a primary research mentor, each trainee will be supervised by a mentorship committee, including the program directors, to oversee and evaluate his/her scientific progress and career development. Trainees will work side-by-side with other M.D., Ph.D., M.D./Ph.D. pre-doctoral or post-doctoral trainees. Periodic evaluations, coupled with formal course work, will provide a rigorous intellectual foundation for each trainee's scientific endeavors. The institutional commitment to pediatric research at CHP and the School of Medicine has been substantial. The UPMC and the CHP commitment is $7.5 million each year for the next 3 years, including the Dec 2008 opening of a new state of the art pediatric research building. Thus, the overall achievements of this program, its critical intellectual mass, and the tremendous resources at the CHP and the UOP have made this an outstanding program to train much needed pediatric endocrine physician-scientists, encourage their transition to K awards,and cultivate their success as independent R01 funded investigators. With increasing national interest in pediatric endocrinology, as reflected by the numbers of applicants, we anticipate that this research training program will provide a mechanism through which contemporary physician-scientists will obtain the tools fundamental for successful and productive academic careers in translational research. RELEVANCE (See instructions): This pediatric endocrine and diabetes training program, funded by a T-32 for the past 14 years, has produced a cadre of nationally and internationally recognized pediatric endocrine researchers including 6 Chairs of pediatrics, 9 Division Chiefs and 2 Presidents of the Lawson Wilkins Pediatric Endocrine Society. Our program, therefore, has traditionally been a major provider of pediatric endocrinologists in the USA. This program is one of only 16 NIDDK funded pediatric ^endocrine/diabetes training grants, whose graduates are essential to the academic future of the subspecialty.