Intergenerational Transmission of Alcohol Involvement

酒精参与的代际传播

• 批准号: 8496652
• 负责人: SUSAN E LUCZAK
• 金额: $ 63.25万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-10 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8496652
• 关键词: 12 year old; 3 year old; Accounting; Adolescent; Affect; African; Age; Alcohol abuse; Alcohol consumption; Asian Indian; Behavioral; Biological; Child health care; Childhood; Cognitive; Cohort Effect; Complex; Data; Data Set; Development; Disease; Ethnic Origin; Ethnic group; Exposure to; Family; Family history of; Fathers; Female; Future; Gender; Generations; Genetic; Genetic Risk; Harm Reduction; Individual; Individual Differences; Interview; Island; Joints; K-Series Research Career Programs; Knowledge; Longitudinal Studies; Mauritius; Measures; Mediating; Mediation; Modeling; Mothers; Muslim population group; Nutritional; Parenting behavior; Parents; Participant; Pathway interactions; Personality; Population; Prevalence; Prevention; Prevention program; Principal Investigator; Process; Prospective Studies; Psychophysiology; Psychosocial Factor; Regulation; Reporting; Research; Risk; Risk Factors; Role; Sampling; Sex Characteristics; Siblings; Spouses; Testing; Time; Woman; alcohol behavior; alcohol involvement; alcohol use initiation; cohort; contextual factors; drinking; early drinking; ethnic difference; grandparent; hazardous drinking; intergenerational; male; model development; offspring; peer; psychosocial; public health relevance; social; transmission process

DESCRIPTION (provided by applicant): Individuals with a family history of alcohol problems are at increased risk for developing alcohol problems, but the specific mechanisms by which alcohol behaviors are transmitted from one generation to the next are not well understood. The purpose of the proposed study is to investigate the development of alcohol involvement (i.e. alcohol use and problems) and its intergenerational transmission among participants in the Joint Child Health Project, an ongoing three-generational longitudinal study on the island of Mauritius. In 1972, a general sample cohort of 1,795 male and female 3 year-olds were tested on psycho-physiological, nutritional, cognitive, and temperamental factors, while their first-generation parents were assessed on psychosocial variables. This second generation is now 40 years old and along with their spouses will be assessed on measures of lifetime alcohol involvement and associated genetic, personality, cultural, familial, parenting, and psychosocial measures. The third-generation offspring also have been well characterized on psycho-physiological, nutritional, cognitive, and temperamental factors between the ages of 3 and 11 years. The third-generation offspring who are 12 years of age or older will now be assessed for early alcohol involvement and associated variables, including genetic, familial, peer, cultural, and social influences, personality and individual differences, and psychosocial, cognitive, and behavioral variables. The multigenerational dataset and unique setting of the JCHP will enable us to tease apart the complex interplay of risk and protective factors in ways that cannot be done in U.S. samples where alcohol use is nearly universal. Findings will also test the degree to which pathway models of the development of alcohol problems generalize to a non-Western culture. The three specific aims of the proposed study are: 1) to create a rich dataset for testing mechanisms of alcohol involvement over three generations, 2) to test hypothesized mechanisms for the early initiation of alcohol use in G3 offspring, and 3) to test mechanisms for the progression from initiation to hazardous drinking in G3 offspring. This multigenerational prospective study has sufficient power and comprehensive assessments of childhood precursors and alcohol involvement to disentangle the complex interactive effects of individual differences, psychosocial, biological, cultural, and genetic risk and protective factors on alcohol involvement. Knowledge of such processes will inform future prevention and harm reduction research and efforts.

描述（由申请人提供）：具有酒精问题家族史的个体发生酒精问题的风险增加，但酒精行为从一代传递到下一代的具体机制尚不清楚。拟议研究的目的是调查参与酒精的发展（即酒精使用和问题）及其代际传递的参与者之间的联合儿童健康项目，正在进行的三代纵向研究毛里求斯岛。1972年，对1,795名3岁男女儿童的一般样本队列进行了心理生理、营养、认知和气质因素的测试，同时对他们的第一代父母进行了心理社会变量的评估。这第二代现在40岁，沿着他们的配偶将被评估一生的酒精参与和相关的遗传，个性，文化，家庭，养育和心理社会措施的措施。第三代后代在3至11岁之间的心理生理、营养、认知和气质因素方面也有很好的特征。现在将评估12岁或以上的第三代后代的早期酒精参与和相关变量，包括遗传，家庭，同龄人，文化和社会影响，个性和个体差异，以及心理，认知和行为变量。JCHP的多代数据集和独特的设置将使我们能够以在美国样本中无法做到的方式梳理风险和保护因素之间复杂的相互作用，在美国，酒精使用几乎是普遍的。研究结果还将测试酒精问题发展的途径模型推广到非西方文化的程度。这项研究的三个具体目标是：1）创建一个丰富的数据集，用于测试三代人的酒精参与机制，2）测试G3后代早期开始饮酒的假设机制，3）测试G3后代从开始到危险饮酒的进展机制。这项多代前瞻性研究有足够的力量和全面的评估儿童的前兆和酒精参与解开复杂的互动影响的个体差异，心理社会，生物，文化和遗传风险和保护因素对酒精参与。对这些过程的了解将为今后的预防和减少危害的研究和努力提供信息。