COPD and Response to Traffic Related Particles

慢性阻塞性肺病和对交通相关颗粒的反应

基本信息

批准号：
8481548
负责人：
ERIC GARSHICK
金额：
$ 59.12万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-06-05 至 2017-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8481548
关键词：
Accident and Emergency department Acute Address Adverse effects Air Pollution Area Biological Assay Biological Markers Blood Vessels Boston C-reactive protein Carbon Black Caring Cessation of life Chronic Obstructive Airway Disease Clinical Communities Disease Dose Effectiveness Epidemiologic Studies Epidemiology Exposure to Health Home environment Hospitalization Hospitals Inflammation Inflammatory Interleukin-6 Knowledge Lead Lung Lung diseases Measures Medicare Modeling Monitor Morbidity - disease rate Outpatients Oxidative Stress Particulate Matter Patients Persons Physicians Plasma Pollution Population Prevalence Prevention Pulmonary Function Test/Forced Expiratory Volume 1 Records Recruitment Activity Research Project Grants Risk Sample Size Sampling Time Treatment Cost Validation Vascular Cell Adhesion Molecule-1 Visit administrative database base clinical care cohort cost design disability follow-up land use mortality novel oxidation particle premature pulmonary function respiratory response trafficking

项目摘要

DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is a common disease that results in considerable morbidity and mortality. Epidemiological studies indicate that persons with COPD are particularly susceptible to the effects of traffic related particles. To date, our knowledge regarding these effects is mostly derived from community-based epidemiologic studies using administrative databases and population exposures. Epidemiological observations indicating effects in large population samples have not yet been demonstrated in patients with COPD and the mechanisms of disease remain uncertain. Previous efforts to study the health effects of air pollution in patients with COPD have been limited by inadequate sample size, an inadequate assessment of personal exposure, and lack of a suitable cohort. We have addressed these limitations and will study the effects of traffic-related pollution in 300 persons with moderate to severe COPD recruited from patients receiving clinical care at VA Boston. We hypothesize that when assessed over one year, exposure to traffic-related particles as measured by black carbon will result in exacerbations of COPD, a reduction in pulmonary function, an increase in measures of systemic inflammation, and an increase in systemic oxidative stress in a dose-related manner. Exposure will be assessed by a Boston-area black carbon spatio-temporal land use regression model with model validation by in-home monitoring The information obtained from this research project will define the exposure response relationships between traffic-related particles and the clinical, pulmonary, and systemic responses to air pollution in patients with COPD.

描述（由申请人提供）：慢性阻塞性肺疾病（COPD）是一种常见疾病，导致相当大的发病率和死亡率。流行病学研究表明，患有COPD的人特别容易受到与交通相关颗粒的影响。迄今为止，我们对这些影响的了解主要来自使用行政数据库和人口暴露的基于社区的流行病学研究。流行病学观察表明，在COPD患者中尚未证明对大量人群样本的影响，疾病的机制尚不确定。先前研究空气污染对COPD患者的健康影响的努力受到样本量不足，个人暴露评估不足以及缺乏合适的队列的限制。我们已经解决了这些局限性，并将研究与在波士顿接受临床护理的患者招募的300人中与交通相关污染的影响。我们假设在评估一年以上时，通过黑碳衡量的与交通相关的颗粒的暴露将导致COPD加剧，肺功能的降低，系统性炎症的量度增加以及剂量相关方式中系统性氧化应激的增加。接触将通过波士顿地区黑色碳时空时空利用回归模型和模型验证，通过内部监测从该研究项目获得的信息，将定义与COPD患者患者的临床，肺部和全身污染的全身反应之间的暴露响应关系。