Retrospective assessment of radon progeny and pollution effects in COPD

氡子体和 COPD 污染影响的回顾性评估

• 批准号: 9980902
• 负责人: ERIC GARSHICK
• 金额: $ 20.29万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9980902
• 关键词: 8-hydroxy-2' -deoxyguanosine; Address; Affect; Age; Air Pollution; Archives; Back; Biological Markers; Blood; C-reactive protein; Caliber; Carbon Black; Carcinogens; Cause of Death; Cessation of life; Chronic Obstructive Airway Disease; Cities; Clinical; County; DNA; Development; Disease; Equilibrium; Exposure to; Floor; Gases; Half-Life; Health; Home environment; Impairment; Individual; Indoor environment; Inflammation; Inflammatory; Inhalation; Interleukin-6; Joints; Knowledge; Lead; Link; Lipids; Lung; Lung diseases; Malignant neoplasm of lung; Malondialdehyde; Massachusetts; Measurement; Measures; National Institute of Environmental Health Sciences; Natural Products; Noble Gases; Nuclear Accidents; Older Population; Outcome; Oxidative Stress; Particulate Matter; Patients; Physical Performance; Plasma; Pollution; Polonium; Pulmonary Function Test/Forced Expiratory Volume 1; Radiation; Radioactive; Radioisotopes; Radium; Radon; Regulation; Research; Research Design; Risk; Risk Factors; Sampling; Soil; Testing; Time; Toxic effect; Ultrafine; United States Environmental Protection Agency; Uranium; Urine; Veterans; Work; ambient air pollution; base; cancer risk; cell injury; clinically relevant; indoor exposure; mortality; novel; oxidative damage; particle; pulmonary function; residence; response; urinary

Radon (Rn) is a radioactive gas that decays into radiation-emitting progenies capable of inducing cellular damage once inhaled. Residential exposure to Rn is common; however, current health concerns and regulations are based only on its effects as a lung carcinogen. It is not known whether exposure to Rn decay products results in other, non-cancer, adverse health effects, as we propose in chronic obstructive pulmonary disease (COPD) patients. In this exploratory and developmental application, we will assess whether exposure to Rn decay products, as assessed using lead-210 (210Pb), the progeny with the longest half-life, enhances the toxicity (and health effects) of air pollution particles. In 170 Eastern Massachusetts COPD patients, we have previously assessed indoor-home exposures to PM2.5 and black carbon by collecting up to four 7-day samples seasonally over the period of one year. Since 210Pb is in equilibrium with alpha (α)-emitting progeny on archived PM2.5 filter samples, the measurement of total α- radiation emitted from them will permit back-calculation of residential 210Pb levels (as a surrogate measure of Rn progeny) present at the time of sampling. Therefore, we will investigate whether exposure to Rn progeny (as210Pb) modifies (increases) the effect of PM2.5 and black carbon on: 1) plasma biomarkers of systemic inflammation (C-reactive protein and interleukin-6); 2) urinary biomarkers of oxidative damage to lipids (malondialdehyde) and DNA (8-hydroxy-2'-deoxyguanosine); and 3) pulmonary function (FEV1, FVC, and FEV1/FVC). This research design encompasses a strong and novel exposure component linked to clinically relevant and mechanistic outcomes. These are relevant to the health of COPD patients, which is a common disease affecting approximately 11% of the US population older than age 55 years.

氡(Rn)是一种放射性气体，会衰变成能够诱导细胞产生辐射的子体 伤害一旦吸入。居民接触氡是很常见的；然而，当前的健康问题和 监管仅基于其作为肺癌致癌物的影响。目前尚不清楚暴露在氡中是否会衰变。 产品会导致其他非癌症的不良健康影响，正如我们在慢性阻塞性肺疾病中所建议的那样 疾病(COPD)患者。在这种探索性和发展性的应用中，我们将评估暴露于 利用半衰期最长的子体铅-210(210Pb)评估的Rn衰变产物，增强了 空气污染颗粒物的毒性(和健康影响)。 在170名马萨诸塞州东部的COPD患者中，我们之前评估了室内和家庭暴露在PM2.5中的情况 在一年的时间里，通过季节性收集最多四个7天的样本，来获得碳和炭黑。因为210Ph是 在与归档PM2.5过滤样品上的α(α)排放子体保持平衡的情况下，总α的测量- 从它们发出的辐射将允许反向计算住宅的210Pb水平(作为 Rn子代)在采样时存在。因此，我们将调查是否暴露于Rn子代 (As210Pb)修饰(增加)PM2.5和黑碳对：1)系统性血浆生物标志物的影响 炎症(C-反应蛋白和白介素6)；2)脂质氧化损伤的尿液生物标志物 (丙二醛)和DNA(8-羟基-2‘-脱氧鸟苷)；以及3)肺功能(FEV1、FVC和 FEV1/FVC)。这项研究设计包含一种强大而新颖的暴露成分，与临床上 相关和机械性的结果。这些都与COPD患者的健康有关，这是一种常见的 影响美国55岁以上人口的约11%的疾病。

项目成果

Geomagnetic disturbances reduce heart rate variability in the Normative Aging Study.

• DOI: 10.1016/j.scitotenv.2022.156235
• 发表时间: 2022-09-15
• 期刊: SCIENCE OF THE TOTAL ENVIRONMENT
• 影响因子: 9.8
• 作者: Vieira, Carolina L. Zilli;Chen, Kelly;Garshick, Eric;Liu, Man;Vokonas, Pantel;Ljungman, Petter;Schwartz, Joel;Koutrakis, Petros
• 通讯作者: Koutrakis, Petros

The role of solar and geomagnetic activity in endothelial activation and inflammation in the NAS cohort.

• DOI: 10.1371/journal.pone.0268700
• 发表时间: 2022
• 期刊: PloS one
• 影响因子: 3.7

Solar and geomagnetic activity reduces pulmonary function and enhances particulate pollution effects.

• DOI: 10.1016/j.scitotenv.2022.156434
• 发表时间: 2022-09-10
• 期刊: SCIENCE OF THE TOTAL ENVIRONMENT
• 影响因子: 9.8
• 作者: Anand, Kritika;Vieira, Carolina L. Z.;Garshick, Eric;Wang, Veronica;Blomberg, Annelise;Gold, Diane R.;Schwartz, Joel;Vokonas, Pantel;Koutrakis, Petros
• 通讯作者: Koutrakis, Petros