Vitamin D, Respiratory Function, and Illness in Chronic SCI

维生素 D、呼吸功能和慢性 SCI 中的疾病

• 批准号: 8593481
• 负责人: ERIC GARSHICK
• 金额: --
• 依托单位: VA BOSTON HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-10-01 至 2017-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8593481
• 关键词: Accounting; Address; Adverse effects; Age; Basic Science; Biological; Blood specimen; Boston; Cardiopulmonary; Cardiovascular system; Chest; Chronic; Chronic Obstructive Airway Disease; Clinical; Clinical Trials; Disease; Enrollment; Epidemiologic Studies; Epidemiology; Forced expiratory volume function; Future; Health; Height; Hospitalization; Individual; Infection; Injury; Learning; Literature; Lung; Measurement; Measures; Morbidity - disease rate; Neurologic; Pathway interactions; Persons; Physiological; Pilot Projects; Predisposition; Program Reviews; Pulmonary Function Test/Forced Expiratory Volume 1; Questionnaires; Recording of previous events; Recruitment Activity; Reporting; Research; Respiratory Muscles; Respiratory Tract Infections; Respiratory physiology; Risk; Risk Factors; Role; Seasons; Severities; Smoking; Spinal cord injury; Spirometry; Supplementation; Testing; Time; Vitamin D; Vitamin D Deficiency; Weight; Wheezing; abstracting; base; bone health; bone metabolism; cohort; design; disability; disorder prevention; follow-up; mortality; muscle strength; pressure; programs; prospective; public health relevance; pulmonary function; pulmonary function decline; respiratory; response

DESCRIPTION Abstract: The role of vitamin D in bone metabolism is well established, but recent epidemiologic and basic science studies suggest that vitamin D related pathways are involved in the determination of pulmonary function, risk of infection, and respiratory health, all factors influencing morbidity and mortality in chronic SCI. These observations regarding vitamin D are highly significant as vitamin D deficiency and insufficiency is common in chronic spinal cord injury. Previous research conducted at VA Boston in persons with chronic SCI has demonstrated that longitudinal decline in pulmonary function and chest illness risk are not attributable to level and severity of injury, but to other potentially modifiable factors. The VA Boston SCI research program has conducted epidemiologic studies focused on identifying factors responsible for pulmonary function decline and pulmonary-related illness in chronic SCI. In a cohort of 330 persons with chronic SCI, it is proposed to longitudinally assess the relationship between vitamin D levels with pulmonary function and the risk of future chest illness. Understanding these adverse effects of lower vitamin D levels is particularly important in SCI because of the increased risk of pulmonary-related diseases and infection. Our approach is efficient because it will take advantage of a large SCI cohort enrolled in an ongoing longitudinal health study. The demonstration of an association between pulmonary function decline and an increased risk of chest illness with lower levels of vitamin D would result in a clinical trial assessing the potential benefits of vitamin D supplementation that would potentially identify an approach to disease prevention in SCI.

描述 摘要：维生素D在骨代谢中的作用已经确定，但是最近的流行病学和基础科学研究表明，与维生素D相关的途径与确定肺功能，感染风险和呼吸健康有关，所有影响慢性SCI发病率和死亡率的因素。这些有关维生素D的观察结果非常重要，因为维生素D缺乏症和不足在慢性脊髓损伤中很常见。先前在波士顿对患有慢性SCI的人进行的研究表明，肺功能和胸部疾病风险的纵向下降并不归因于伤害的水平和严重程度，而是其他潜在的可修改因素。 VA波士顿SCI研究计划进行了流行病学研究，重点是识别导致肺部功能下降和肺部科学肺相关疾病的因素。在一组330名患有慢性SCI的人群中，提议纵向评估维生素D水平与肺功能与未来胸部疾病的风险之间的关系。了解较低维生素D水平的这些不良影响在 SCI是因为与肺部相关疾病和感染的风险增加。我们的方法是有效的，因为它将利用正在进行的纵向健康研究中的大型SCI队列。肺功能下降与胸部疾病风险增加与维生素D较低的风险之间的相关性的证明将导致一项临床试验评估补充维生素D的潜在益处，该试验有可能确定SCI中预防疾病的方法。