Training Grant: Functional Protemics of Aging

描述（由申请人提供）：明尼苏达大学的一组研究人员寻求更新“衰老功能蛋白质组学”，这是一个跨学科的培训计划，支持4名博士前和4名博士后学员。计划教师从明尼苏达大学的四个研究生课程中抽取学员：生物化学，分子生物学和生物物理学（BMBB），康复科学（RSc），神经科学（NSc）和化学（Chem）。该培训计划包括两个主要部分：（1）研究培训，重点是使用蛋白质组学技术来揭示与年龄相关的组织功能丧失和/或与年龄相关的疾病背后的分子细节。(2)在老年学和蛋白质组学的教学和经验培训，为学员提供一个坚实的基础，在老龄化研究成功的职业生涯。研究部分包括三个研究领域，重点是在衰老过程中保持生理功能或了解疾病机制：肌肉（Ervasti，Lowe，Metzger，托马斯，Thompson），中枢神经系统（Ferrington，Li，Low）和能量代谢和长寿（Arriaga，Bernlohr，Griffin，Hendrickson，Kim）。虽然这些领域的范围很广，但它们通过对蛋白质组学和衰老的共同兴趣而在主题上相关。蛋白质组学分析是利用培训教师揭示改变蛋白质含量，结合伙伴，和翻译后修饰发生在老化的组织。这些信息有助于确定蛋白质结构和功能中与年龄和疾病相关的变化的机制基础。我们的研究得到了明尼苏达州超级计算机研究所质谱和蛋白质组学中心配备各种最先进质谱仪和生物信息学平台的优秀核心的支持。培训教师实验室还包含专业分析设备，这些设备通常在计划教师之间共享。这有助于促进教师和学员之间广泛的跨学科合作。培训计划还包括通过老年学和蛋白质组学课程的教学培训，以及通过会议，研讨会，专题讨论会，期刊俱乐部和与计划教职员工的小组会议进行老龄化研究的体验式培训。体验式培训旨在最大限度地提高学员之间的互动和培训教师从多个实验室和科学家以外的MN的U。总而言之，该培训计划的主要目标是帮助杰出的年轻科学家开发作为老龄化研究中的独立调查员和教育工作者的富有成效的职业所需的知识和技术工具。

DESCRIPTION (provided by applicant): A group of investigators at the University of Minnesota seeks to renew "Functional Proteomics of Aging", an interdisciplinary Training Program that supports 4 predoctoral and 4 postdoctoral trainees. Program faculty members draw trainees from four graduate programs at the University of Minnesota: Biochemistry, Molecular Biology and Biophysics (BMBB), Rehabilitation Sciences (RSc), Neuroscience (NSc), and Chemistry (Chem). This Training Program contains two major components: (1) Research training that focuses on the use of proteomic technology to reveal the molecular details behind the age-related loss in tissue function and/or age-related disease. (2) Didactic and experiential training in gerontology and proteomics to provide trainees with a solid foundation for launching successful careers in aging research. The research component consists of three research areas that focus on retaining physiological function during aging or understanding disease mechanism: muscle (Ervasti, Lowe, Metzger, Thomas, Thompson), the central nervous system (Ferrington, Li, Low) and energy metabolism and longevity (Arriaga, Bernlohr, Griffin, Hendrickson, Kim). While these areas are broad in scope, they are thematically related through a shared interest in proteomics and aging. Proteomic analysis is utilized by Training faculty to reveal altered protein content, binding partners, and post-translational modifications that occur in aged tissue. This information aids in determining the mechanistic basis for age- and disease-related changes in protein structure and function. Our research is supported by outstanding cores equipped with a variety of state-of-the-art mass spectrometers in the Center for Mass Spectrometry and Proteomics and bioinformatics platforms in the Minnesota Supercomputers Institute. Training faculty laboratories also contain specialized analytical equipment that is commonly shared between Program faculty. This has helped foster extensive interdisciplinary collaborations among faculty and trainees. The Training Program also includes both didactic training via coursework in gerontology and proteomics, as well as experiential training in aging research via conferences, seminars, symposia, journal clubs, and group meetings with Program faculty members. The experiential training is designed to maximize interaction among trainees and Training faculty from multiple labs and with scientists outside the U of MN. In summary, the primary goal of this Training Program is to help exceptional young scientists develop the intellectual and technical tools needed for productive careers as independent investigators and educators in aging research.