Training Grant: Functional Protemics of Aging

培训补助金：衰老的功能蛋白质学

• 批准号: 8850365
• 负责人: Deborah Ann Ferrington
• 金额: $ 28.26万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8850365
• 关键词: Aging; Grant; Training

DESCRIPTION (provided by applicant): A group of investigators at the University of Minnesota seeks to renew "Functional Proteomics of Aging", an interdisciplinary Training Program that supports 4 predoctoral and 4 postdoctoral trainees. Program faculty members draw trainees from four graduate programs at the University of Minnesota: Biochemistry, Molecular Biology and Biophysics (BMBB), Rehabilitation Sciences (RSc), Neuroscience (NSc), and Chemistry (Chem). This Training Program contains two major components: (1) Research training that focuses on the use of proteomic technology to reveal the molecular details behind the age-related loss in tissue function and/or age-related disease. (2) Didactic and experiential training in gerontology and proteomics to provide trainees with a solid foundation for launching successful careers in aging research. The research component consists of three research areas that focus on retaining physiological function during aging or understanding disease mechanism: muscle (Ervasti, Lowe, Metzger, Thomas, Thompson), the central nervous system (Ferrington, Li, Low) and energy metabolism and longevity (Arriaga, Bernlohr, Griffin, Hendrickson, Kim). While these areas are broad in scope, they are thematically related through a shared interest in proteomics and aging. Proteomic analysis is utilized by Training faculty to reveal altered protein content, binding partners, and post-translational modifications that occur in aged tissue. This information aids in determining the mechanistic basis for age- and disease-related changes in protein structure and function. Our research is supported by outstanding cores equipped with a variety of state-of-the-art mass spectrometers in the Center for Mass Spectrometry and Proteomics and bioinformatics platforms in the Minnesota Supercomputers Institute. Training faculty laboratories also contain specialized analytical equipment that is commonly shared between Program faculty. This has helped foster extensive interdisciplinary collaborations among faculty and trainees. The Training Program also includes both didactic training via coursework in gerontology and proteomics, as well as experiential training in aging research via conferences, seminars, symposia, journal clubs, and group meetings with Program faculty members. The experiential training is designed to maximize interaction among trainees and Training faculty from multiple labs and with scientists outside the U of MN. In summary, the primary goal of this Training Program is to help exceptional young scientists develop the intellectual and technical tools needed for productive careers as independent investigators and educators in aging research.

描述（由申请人提供）：明尼苏达大学的一组调查员试图续签“衰老的功能蛋白质组学”，这是一个跨学科培训计划，支持4位前学位和4位博士后学员。计划教师从明尼苏达大学的四个研究生课程中吸引了学员：生物化学，分子生物学和生物物理学（BMBB），康复科学（RSC），神经科学（NSC）和化学（Chem）。该培训计划包含两个主要组成部分：（1）研究培训的重点是使用蛋白质组学技术来揭示组织功能和/或与年龄相关疾病的年龄相关损失背后的分子细节。 （2）老年病学和蛋白质组学领域的教学和体验培训，为受训者提供稳固的基础，以启动衰老研究的成功职业。该研究组成部分由三个研究领域组成，旨在在衰老或理解疾病机制期间保持生理功能：肌肉（Ervasti，Lowe，Metzger，Metzger，Thomas，Thompson），中枢神经系统（Ferrington，Li，Low）和能量代谢和寿命（Enseralist和寿命）尽管这些领域的范围很广，但它们通过对蛋白质组学和衰老的共同兴趣在主题上是相关的。蛋白质组学分析用于培训教师来揭示蛋白质含量，结合伴侣和老年组织中发生的翻译后修饰的改变。该信息有助于确定蛋白质结构和功能与年龄和疾病相关的变化的机理基础。我们的研究得到了明尼苏达州超级计算机研究所的质谱和蛋白质组学和生物信息学平台中心的各种最先进的质谱仪的支持。培训教师实验室还包含专业的分析设备，这些设备通常在课程教师之间共享。这有助于培养教师和学员之间的广泛跨学科合作。该培训计划还包括通过老年学课程和蛋白质组学课程进行教学培训，以及通过会议，研讨会，研讨会，期刊俱乐部和与计划教职员工的小组会议进行老化研究的体验培训。经验培训旨在最大程度地提高学员之间的互动和来自多个实验室的培训教师以及MN以外的科学家。总而言之，该培训计划的主要目标是帮助杰出的年轻科学家开发成生产力职业所需的智力和技术工具，成为独立的研究人员和教育工作者的老龄化研究。