Training Grant: Functional Protemics of Aging

培训补助金：衰老的功能蛋白质学

• 批准号: 8792316
• 负责人: Deborah Ann Ferrington
• 金额: $ 28.27万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8792316
• 关键词: Aging; Grant; Training

DESCRIPTION (provided by applicant): A group of investigators at the University of Minnesota seeks to renew "Functional Proteomics of Aging", an interdisciplinary Training Program that supports 4 predoctoral and 4 postdoctoral trainees. Program faculty members draw trainees from four graduate programs at the University of Minnesota: Biochemistry, Molecular Biology and Biophysics (BMBB), Rehabilitation Sciences (RSc), Neuroscience (NSc), and Chemistry (Chem). This Training Program contains two major components: (1) Research training that focuses on the use of proteomic technology to reveal the molecular details behind the age-related loss in tissue function and/or age-related disease. (2) Didactic and experiential training in gerontology and proteomics to provide trainees with a solid foundation for launching successful careers in aging research. The research component consists of three research areas that focus on retaining physiological function during aging or understanding disease mechanism: muscle (Ervasti, Lowe, Metzger, Thomas, Thompson), the central nervous system (Ferrington, Li, Low) and energy metabolism and longevity (Arriaga, Bernlohr, Griffin, Hendrickson, Kim). While these areas are broad in scope, they are thematically related through a shared interest in proteomics and aging. Proteomic analysis is utilized by Training faculty to reveal altered protein content, binding partners, and post-translational modifications that occur in aged tissue. This information aids in determining the mechanistic basis for age- and disease-related changes in protein structure and function. Our research is supported by outstanding cores equipped with a variety of state-of-the-art mass spectrometers in the Center for Mass Spectrometry and Proteomics and bioinformatics platforms in the Minnesota Supercomputers Institute. Training faculty laboratories also contain specialized analytical equipment that is commonly shared between Program faculty. This has helped foster extensive interdisciplinary collaborations among faculty and trainees. The Training Program also includes both didactic training via coursework in gerontology and proteomics, as well as experiential training in aging research via conferences, seminars, symposia, journal clubs, and group meetings with Program faculty members. The experiential training is designed to maximize interaction among trainees and Training faculty from multiple labs and with scientists outside the U of MN. In summary, the primary goal of this Training Program is to help exceptional young scientists develop the intellectual and technical tools needed for productive careers as independent investigators and educators in aging research.

描述(由申请者提供)：明尼苏达大学的一组研究人员试图更新“衰老的功能蛋白质组学”，这是一个支持4名博士前和4名博士后实习生的跨学科培训计划。该项目的教职员工来自明尼苏达大学的四个研究生项目：生物化学、分子生物学和生物物理学(BMBB)、康复科学(RSC)、神经科学(NSC)和化学(Chem)。这一培训计划包括两个主要部分：(1)研究培训，重点是使用蛋白质组技术来揭示与年龄相关的组织功能丧失和/或与年龄相关的疾病背后的分子细节。(2)老年学和蛋白质组学的授课和体验式培训，为学员在老龄研究领域取得成功奠定坚实的基础。研究部分由三个研究领域组成，重点是在衰老过程中保持生理功能或了解疾病机制：肌肉(Erasti，Lowe，Metzger，Thomas，Thompson)，中枢神经系统(Ferrington，Li，Low)以及能量代谢和长寿(Arriaga，Bernlohr，Griffin，Hendrickson，Kim)。虽然这些领域的范围很广，但它们通过对蛋白质组学和衰老的共同兴趣而在主题上相互关联。蛋白质组学分析被培训人员用来揭示发生在老化组织中的改变的蛋白质含量、结合伙伴和翻译后修饰。这些信息有助于确定与年龄和疾病相关的蛋白质结构和功能变化的机制基础。我们的研究得到了出色的核心的支持，这些核心配备了明尼苏达超级计算机研究所的质谱学和蛋白质组学中心的各种最先进的质谱仪和生物信息学平台。培训教员实验室还包括专门的分析设备，这些设备通常由项目教员共享。这有助于促进教职员工和实习生之间广泛的跨学科合作。培训计划还包括通过老年学和蛋白质组学的课程教学培训，以及通过会议、研讨会、座谈会、期刊俱乐部和与计划教职员工的小组会议进行的老龄研究经验培训。体验式培训旨在最大限度地促进来自多个实验室的受训者和培训教师之间的互动，以及与明尼苏达大学以外的科学家的互动。总而言之，该培训计划的主要目标是帮助杰出的年轻科学家开发所需的智力和技术工具，以在老龄化研究中作为独立调查人员和教育工作者从事富有成效的职业生涯。