Genome-Wide Association Studies of Adiposity in Samoans

项目摘要--“萨摩亚人肥胖的全基因组关联研究” 这一新应用的目标是定义肥胖及其相关的遗传变异 成年萨摩亚人的表型。我们将使用全基因组关联方法来利用较新的 更强大的技术来识别与以下基因相关的单核苷酸多态性(SNP)变体 肥胖表型。我们将使用2500名农村成年人的人口样本进行这些研究 萨摩亚是一个正在经历营养转型的独立国家。我们将重复这些发现 通过对三个不同研究的进一步分析，来自我们对重要SNPs的全基因组关联研究 样本：来自美属萨摩亚和萨摩亚早期研究的2500名萨摩亚人的独立样本，以及 克罗地亚1,500名成年人和中国1,000名成年人。然后我们将确定重要的 基因，并确定测序基因中与肥胖有关的特定遗传变异 这三个样本。最后，我们将探索基因与环境的相互作用，利用已识别的 测序区域的遗传变异和生活方式和环境的实质性异质性 萨摩亚境内的营养行为。从这项研究中获得的知识将有助于 在包括美国在内的萨摩亚人中进行肥胖干预，并可能推广到其他太平洋地区 岛民群体。

Project Summary - "Genome-wide association studies of adiposity in Samoans" The goal of this new application is to define the genetic variation that underlies obesity and obesity-related phenotypes among adult Samoans. We will use genome-wide association methods to take advantage of newer more powerful techniques to identify single nucleotide polymorphism (SNP) variants that are associated with adiposity phenotypes. We will conduct these studies using a population sample of 2,500 adults from rural areas of Samoa, an independent nation experiencing the nutritional transition. We will replicate the findings from our genome-wide association studies of important SNPs by further analysis in three different study samples: an independent sample of 2,500 Samoans from earlier studies in American Samoa and Samoa, and 1,500 adults from Croatia and 1,000 adults from China. We will then determine the sequences of the important genes and determine the specific genetic variants in the sequenced genes that are associated with obesity in these three samples. Finally, we will explore gene-environment interactions, taking advantage of identified genetic variants in the sequenced regions and the substantial environmental heterogeneity in lifestyle and nutritional behaviors within Samoa. The knowledge gained from this research will aid the development of interventions on obesity among Samoans including those in the US and may be generalizable to other Pacific Islander groups.