Genome-Wide Association Studies of Adiposity in Samoans

萨摩亚人肥胖的全基因组关联研究

• 批准号: 8598505
• 负责人: Stephen T. McGarvey
• 金额: $ 55.61万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8598505
• 关键词: Abdomen; Accounting; Adult; Alcohol consumption; American; American Samoa; Architecture; Behavior; Bioinformatics; Biological; Blood Pressure; Blood specimen; Body fat; Candidate Disease Gene; China; Chinese People; Clinical Chemistry Tests; Clinical Data; Collection; Complex; Consensus; Croatia; DNA; Data; Demographic Factors; Developed Countries; Developing Countries; Diet; Disease; Economic Development; Education; Environment; Epidemiologic Studies; Exposure to; Fasting; Fatty Acids; Gene Family; Genes; Genetic; Genetic Variation; Genomics; Genotype; Glucose; Goals; Height; Heterogeneity; Hip region structure; Inherited; Insulin; Knowledge; Leptin; Life; Life Style; Lipids; Measurement; Measures; Methods; Morbidity - disease rate; Nutritional; Obesity; Occupations; Overweight; Pacific Island Americans; Pathway interactions; Pattern; Phenotype; Plasma; Population; Public Health; Recording of previous events; Recruitment Activity; Research; Risk; Rural; Samoa; Samoan; Sampling; Sampling Studies; Serum; Single Nucleotide Polymorphism; Staging; Statistical Methods; Techniques; Testing; United States; Variant; Weight; adiponectin; base; cigarette smoking; design; effective intervention; experience; follow-up; gene environment interaction; genetic analysis; genetic epidemiology; genetic linkage analysis; genetic risk factor; genetic variant; genome wide association study; high risk; mortality; novel; prevent; rural area; success; therapy development; trait

Project Summary - "Genome-wide association studies of adiposity in Samoans" The goal of this new application is to define the genetic variation that underlies obesity and obesity-related phenotypes among adult Samoans. We will use genome-wide association methods to take advantage of newer more powerful techniques to identify single nucleotide polymorphism (SNP) variants that are associated with adiposity phenotypes. We will conduct these studies using a population sample of 2,500 adults from rural areas of Samoa, an independent nation experiencing the nutritional transition. We will replicate the findings from our genome-wide association studies of important SNPs by further analysis in three different study samples: an independent sample of 2,500 Samoans from earlier studies in American Samoa and Samoa, and 1,500 adults from Croatia and 1,000 adults from China. We will then determine the sequences of the important genes and determine the specific genetic variants in the sequenced genes that are associated with obesity in these three samples. Finally, we will explore gene-environment interactions, taking advantage of identified genetic variants in the sequenced regions and the substantial environmental heterogeneity in lifestyle and nutritional behaviors within Samoa. The knowledge gained from this research will aid the development of interventions on obesity among Samoans including those in the US and may be generalizable to other Pacific Islander groups.

项目摘要-“萨摩亚人肥胖症的全基因组关联研究” 这项新应用的目标是确定肥胖和肥胖相关疾病的遗传变异。 成年萨摩亚人的表型。我们将使用全基因组关联方法， 更强大的技术来识别与以下疾病相关的单核苷酸多态性（SNP）变体 肥胖表型我们将使用来自农村的2,500名成年人的人口样本进行这些研究。 萨摩亚是一个正在经历营养转型的独立国家。我们会复制 从我们的全基因组关联研究的重要SNPs通过进一步分析在三个不同的研究， 样本：从早先在美属萨摩亚和萨摩亚进行的研究中获得的2 500名萨摩亚人的独立样本，以及 1,500名来自克罗地亚的成年人和1,000名来自中国的成年人。然后我们将确定重要的 基因，并确定与肥胖相关的测序基因中的特定遗传变异， 这三个样本。最后，我们将探讨基因与环境的相互作用，利用已确定的 测序区域的遗传变异和生活方式的巨大环境异质性， 萨摩亚境内的营养行为。从这项研究中获得的知识将有助于 萨摩亚人的肥胖干预措施，包括美国的干预措施， 岛民团体。