GENOME SCAN FOR OBESITY SUSCEPTIBILITY LOCI IN SAMOANS

描述(改编自研究人员摘要)：肥胖是一个复杂的问题 以全身和局部脂肪组织过剩为特征的表型。它是 发病率和死亡率上升的强烈风险因素，以及主要公众 发达国家和发展中国家的健康问题。肥胖症有很大的 在家系研究和分离分析中显示了遗传成分，但 在识别主要易感基因座方面几乎没有一致性。 治疗肥胖症。在这项研究中，研究人员提议进行全基因组 在波利尼西亚的成年萨摩亚人中扫描肥胖易感基因。的确有 萨摩亚人肥胖率很高，从80%到90%不等 美属萨摩亚人迅速现代化，达到40%-60%，属于更传统的 西萨摩亚人。萨摩亚人由于其独特的基因多样性而减少了遗传多样性 人口历史以及他们对肥胖的快速反应 改变饮食和活动模式，我们怀疑他们会有不同的肥胖 易感基因座多于其他人群。这项研究的目标是 通过三个具体目标来实现。首先，肥胖表型将是 收集的数据包括脂肪质量和体脂百分比、体重指数(BMI)、脂肪 使用人体测量法从周长和皮肤褶皱分布，以及 空腹血清瘦素数据，来自1200名成年人，在大约60名延长 美属萨摩亚的家谱和西萨摩亚的60个延伸家系。第二, 全基因组扫描将使用高度多态的 标记间平均间距为10 cM的遗传标记。第三， 肥胖易感基因的定位将由多点确定 连锁分析主要基于强大而灵活的方差 组件方法。从科学上讲，萨摩亚人提供了一个令人信服的机会 研究肥胖易感人群中肥胖的遗传学。 这项研究具有公共卫生意义，因为它可能会发现肥胖 除萨摩亚人外，易感基因座也适用于普通人群 为长期努力了解 萨摩亚人肥胖的病因和开发针对高危人群的干预措施 和家人。

DESCRIPTION (Adapted from investigator's abstract): Obesity is a complex phenotype characterized by general and regional excess of adipose tissue. It is a strong risk factor for increased morbidity and mortality and a major public health problem in the developed and developing world. Obesity has a substantial genetic component demonstrated in family studies and segregation analyses, but there is little consistency in the identification of major susceptibility loci for obesity. In this study the investigators propose to conduct a genome-wide scan for obesity susceptibility loci among adult Samoans of Polynesia. There is a high prevalence of obesity among Samoans, ranging from 80-90 percent among rapidly modernizing American Samoans to 40-60 percent among more traditional Western Samoans. Samoans have reduced genetic diversity due to their unique population history, and in combination with their rapid obesity responses to altered diet and activity patterns, we suspect they will have different obesity susceptibility loci than in other populations. The objectives of the study will be achieved through three specific aims. First, obesity phenotypes will be collected including fat mass and percent body fat, body mass index (BMI), fat distribution from circumferences and skin folds using anthropometry, and fasting serum leptin data, from 1,200 adults in approximately 60 extended pedigrees in American Samoa and 60 extended pedigrees in Western Samoa. Second, a genome-wide scan will be conducted using a panel of highly polymorphic genetic markers with average spacing of 10 cM between markers. Third, the location of obesity susceptibility loci will be determined by multipoint linkage analysis primarily based on the powerful and flexible variance components approach. Scientifically, Samoans offer a compelling opportunity to study the genetics of obesity in a population highly susceptible to obesity. The study has public health significance because it may identify obesity susceptibility loci applicable for general populations besides Samoans, as well as providing valuable information for the long-term effort to understand the etiology of Samoan obesity and develop interventions with high-risk individuals and families.