GENOME SCAN FOR OBESITY SUSCEPTIBILITY LOCI IN SAMOANS

描述（改编自研究者摘要）：肥胖是一种复杂的 以脂肪组织普遍和局部过量为特征的表型。是 发病率和死亡率增加的一个强有力的风险因素， 发达国家和发展中国家的健康问题。肥胖症有很大的 遗传成分在家系研究和分离分析中得到证实， 主要易感基因座的鉴定缺乏一致性 治疗肥胖症在这项研究中，研究人员建议进行全基因组的 在波利尼西亚的成年萨摩亚人中扫描肥胖易感基因位点。有 萨摩亚人的肥胖率很高， 快速现代化的美属萨摩亚人， 西萨摩亚人。萨摩亚人的遗传多样性因其独特的 人口历史，并结合他们对肥胖的快速反应， 改变饮食和活动模式，我们怀疑他们会有不同的肥胖 比其他人群的易感基因座。研究的目标将 通过三个具体目标实现。首先，肥胖表型将是 收集的数据包括脂肪量和体脂百分比、体重指数（BMI）、脂肪含量、体重指数（BMI）、体重指数（ 使用人体测量法从周长和皮肤褶皱中获得的分布，以及 空腹血清瘦素数据，来自1,200名成年人，约60个扩展 在美属萨摩亚和60个扩展谱系在西萨摩亚。第二、 将使用一组高度多态的 遗传标记之间的平均间距为10 cM。三是 肥胖易感性基因座的位置将通过多点 以强大而灵活的方差为基础的连锁分析 组件方法。在科学上，萨摩亚人提供了一个引人注目的机会， 研究肥胖症易感人群中肥胖症的遗传学。 这项研究具有公共卫生意义，因为它可能识别肥胖 易感基因座适用于除萨摩亚人以外的一般人群，以及 为长期努力了解 萨摩亚肥胖症的病因，并制定针对高危人群的干预措施 和家人

DESCRIPTION (Adapted from investigator's abstract): Obesity is a complex phenotype characterized by general and regional excess of adipose tissue. It is a strong risk factor for increased morbidity and mortality and a major public health problem in the developed and developing world. Obesity has a substantial genetic component demonstrated in family studies and segregation analyses, but there is little consistency in the identification of major susceptibility loci for obesity. In this study the investigators propose to conduct a genome-wide scan for obesity susceptibility loci among adult Samoans of Polynesia. There is a high prevalence of obesity among Samoans, ranging from 80-90 percent among rapidly modernizing American Samoans to 40-60 percent among more traditional Western Samoans. Samoans have reduced genetic diversity due to their unique population history, and in combination with their rapid obesity responses to altered diet and activity patterns, we suspect they will have different obesity susceptibility loci than in other populations. The objectives of the study will be achieved through three specific aims. First, obesity phenotypes will be collected including fat mass and percent body fat, body mass index (BMI), fat distribution from circumferences and skin folds using anthropometry, and fasting serum leptin data, from 1,200 adults in approximately 60 extended pedigrees in American Samoa and 60 extended pedigrees in Western Samoa. Second, a genome-wide scan will be conducted using a panel of highly polymorphic genetic markers with average spacing of 10 cM between markers. Third, the location of obesity susceptibility loci will be determined by multipoint linkage analysis primarily based on the powerful and flexible variance components approach. Scientifically, Samoans offer a compelling opportunity to study the genetics of obesity in a population highly susceptible to obesity. The study has public health significance because it may identify obesity susceptibility loci applicable for general populations besides Samoans, as well as providing valuable information for the long-term effort to understand the etiology of Samoan obesity and develop interventions with high-risk individuals and families.