Balancing expression of PRRs in epithelial innate immune responses to bacteria
Balancing expression of PRRs in epithelial innate immune responses to bacteria
批准号:
8270367
负责人:
Whasun Oh Chung
金额:
$34.4万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-08-01 至 2014-04-30
关键词:
AddressBacteriaCCL20 geneCXCL5 geneCell surfaceCharacteristicsCommunicationDataEnvironmentEnzymesEpithelialEpithelial CellsEpithelial Receptor CellEquilibriumExposure toGoalsHomeostasisImmune responseIndividualInflammatory ResponseInvestigationLeadLigandsMAP Kinase GeneMAPK Signaling Pathway PathwayMediator of activation proteinMolecularMouth DiseasesNatural ImmunityOral cavityPathogenicityPatternPattern recognition receptorPeriodontal DiseasesRNA InterferenceRegulationSignal PathwaySignal TransductionSmall Interfering RNASumTestingTissuesWorkabstractingcytokinemRNA Expressionmicrobialnew therapeutic targetnoveloral bacteriaoral cavity epitheliumpathogenic bacteriapreventprotein expressionreceptorresponse
中文摘要
摘要
上皮组织作为宿主与外界环境之间的第一道防线,
其包括致病性和非致病性细菌。在口腔中,上皮组织是
他们经常暴露在各种细菌中,但大多数人保持健康的体内平衡。
然而,很少有人知道这种自我平衡的关系是如何协调的。初步数据
通过siRNA利用RNA干扰表明,模式之间存在代偿机制,
识别受体(PRRs)。此外,当PRR被激活时,其他PRR的表达也会被抑制。
增大这些数据有力地表明,上皮细胞有新的机制来平衡
PRRs的表达对细菌的应答。本提案中要检验的假设是,
在暴露于口腔细菌后平衡其上皮先天免疫反应,
细菌的特性和致病性。这项工作的目的是了解跨-
上皮受体之间的通讯以及参与的特定信号通路
在上皮先天免疫的PRR交叉通讯中。该提案将调查各种
上皮细胞受体补偿彼此的激活或缺失,
上皮先天免疫反应。此外,本提案将审查是否启动PRR,
差异调节NF B和MAPK信号通路,从而定制上皮先天免疫
对单个细菌的反应。由于细菌具有多种微生物相关的分子模式,
并且上皮细胞表达多种PRR,因此可以合理地预期存在交叉交流
以及在上皮对各种细菌的反应中这些PRR之间的平衡,
适当的先天免疫反应。拟议的研究将有助于更好地了解
口腔上皮细胞对致病性和非致病性的天然免疫反应的方式
细菌,指导一种新的治疗目标,以预防和治疗口腔疾病,如牙周病,
疾病
英文摘要
Abstract
Epithelial tissues function as the first line of defense between the host and the outside environment,
which includes pathogenic and non-pathogenic bacteria. In the oral cavity, epithelial tissues are
constantly exposed to a variety of bacteria, but most individuals maintain a healthy homeostasis.
However, little is known about how this homeostatic relationship is orchestrated. Preliminary data
utilizing RNA interference via siRNA suggest that compensatory mechanisms exist among Pattern
Recognition Receptors (PRRs). Additionally, when a PRR is activated, the expression of other PRRs
increases. These data strongly suggest that epithelial cells have novel mechanisms to balance
expression of PRRs in response to bacteria. The hypothesis to be tested in this proposal is that PRRs
balance their responses in epithelial innate immunity upon exposure to oral bacteria depending on the
characteristics and pathogenicity of the bacteria. The goal of this work is to understand cross-
communication between epithelial receptors as well as the specific signaling pathways that are involved
in the PRR cross-communication in epithelial innate immunity. This proposal will investigate how various
epithelial cell receptors compensate for the activation or absence of one another in inducing appropriate
epithelial innate immune responses. In addition, this proposal will examine if activation of PRRs
differentially regulate the NF¿B and MAPK signaling pathways, thus tailoring epithelial innate immune
responses to individual bacterium. Since bacteria have multiple Microbial-Associated Molecular Patterns
and epithelial cells express multiple PRRs, it is reasonable to expect that there is cross-communication
and balancing between these PRRs in epithelial responses to various bacteria in order to induce
appropriate innate immune responses. The proposed studies will lead to a better understanding of the
way oral epithelia produce appropriate innate immune responses to pathogenic and non-pathogenic
bacteria, guiding a way to new therapeutic targets to prevent and treat oral diseases, such as periodontal
disease.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Dynamics of HIV-infection, Oral Innate Immunity and The Development of Oral Diseases in Children
-
批准号:10534585
-
项目类别:
-
资助金额:$23.36万
-
财政年份:2022
-
负责人:Whasun Oh Chung
-
依托单位:
Dynamics of HIV-infection, Oral Innate Immunity and The Development of Oral Diseases in Children
-
批准号:10653227
-
项目类别:
-
资助金额:$19.48万
-
财政年份:2022
-
负责人:Whasun Oh Chung
-
依托单位:
Balancing expression of PRRs in epithelial innate immune responses to bacteria
-
批准号:8460434
-
项目类别:
-
资助金额:$33.03万
-
财政年份:2009
-
负责人:Whasun Oh Chung
-
依托单位:
Balancing expression of PRRs in epithelial innate immune responses to bacteria
-
批准号:8063062
-
项目类别:
-
资助金额:$33.71万
-
财政年份:2009
-
负责人:Whasun Oh Chung
-
依托单位:
Balancing expression of PRRs in epithelial innate immune responses to bacteria
-
批准号:7825367
-
项目类别:
-
资助金额:$34.75万
-
财政年份:2009
-
负责人:Whasun Oh Chung
-
依托单位:
Balancing expression of PRRs in epithelial innate immune responses to bacteria
-
批准号:7631989
-
项目类别:
-
资助金额:$35.1万
-
财政年份:2009
-
负责人:Whasun Oh Chung
-
依托单位:
Epithelial Innate Immune Response to Oral Bacteria
-
批准号:7255493
-
项目类别:
-
资助金额:$34.14万
-
财政年份:2005
-
负责人:Whasun Oh Chung
-
依托单位:
Epithelial Innate Immune Response to Oral Bacteria
-
批准号:7458100
-
项目类别:
-
资助金额:$33.76万
-
财政年份:2005
-
负责人:Whasun Oh Chung
-
依托单位:
Regulation of Human Beta-Defensins in Epithelia
-
批准号:6954202
-
项目类别:
-
资助金额:$13.55万
-
财政年份:2004
-
负责人:Whasun Oh Chung
-
依托单位:
Regulation of Human Beta-Defensins in Epithelia
-
批准号:7111856
-
项目类别:
-
资助金额:$13.88万
-
财政年份:2004
-
负责人:Whasun Oh Chung
-
依托单位:
Regulation of Human Beta-Defensins in Epithelia
-
批准号:6866735
-
项目类别:
-
资助金额:$13.22万
-
财政年份:2004
-
负责人:Whasun Oh Chung
-
依托单位:
Regulation of Beta-Defensin Expression in Oral Epithelia
-
批准号:7430469
-
项目类别:
-
资助金额:$34.47万
-
财政年份:2000
-
负责人:Whasun Oh Chung
-
依托单位:
Regulation of Beta-Defensin Expression in Oral Epithelia
-
批准号:7637406
-
项目类别:
-
资助金额:$34.47万
-
财政年份:2000
-
负责人:Whasun Oh Chung
-
依托单位:
国内基金
海外基金
Segmented Filamentous Bacteria激活宿主免疫系统抑制其拮抗菌 Enterobacteriaceae维持菌群平衡及其机制研究
-
批准号:81971557
-
项目类别:面上项目
-
资助金额:65.0万元
-
批准年份:2019
-
负责人:毛开睿
-
依托单位:
电缆细菌(Cable bacteria)对水体沉积物有机污染的响应与调控机制
-
批准号:51678163
-
项目类别:面上项目
-
资助金额:64.0万元
-
批准年份:2016
-
负责人:许玫英
-
依托单位: