Regional Oncology Research Center

描述（由申请人提供）：约翰霍普金斯的西德尼·金梅尔综合癌症中心（SKCCC）致力于癌症和相关疾病的研究和教育，并迅速将新知识应用于患者的治疗和肿瘤疾病的预防。本申请请求CCSG继续支持SKCCC的研究计划和共享资源。SKCCC是约翰霍普金斯大学的一个多学科、跨部门的中心。约翰霍普金斯大学正在进行的癌症研究有着广泛的基础。癌症中心的特殊科学计划是跨学科的，并专注于人类疾病。从人类肿瘤发生的分子遗传学基础研究到新的抗肿瘤治疗的临床试验，涵盖了广泛的活动。 癌症中心已建立了12个主要研究项目：癌症生物学（Baylin，Velculescu），血液学恶性肿瘤和BMT（Ambinder，Jones），癌症免疫学（Pardoll），病毒肿瘤学（海沃德，罗登），癌症预防和控制（Groopman，Platz），化学治疗（科尔），前列腺癌（Carducci，Getzenberg），乳腺癌（Stearns，Sukumar），胃肠道癌（Jaffee，克恩）上呼吸消化道癌症（Rudin，Sidransky），脑癌（Grossman，Brem，Laterra），和癌症分子和功能成像（Bhujwalla，Pomper）。二十二个共享资源支持癌症中心研究人员的需求：动物资源，生物信息学，微阵列，癌症功能成像，细胞成像，常用设备，细胞遗传学，实验辐射器，流式细胞术，玻璃器皿清洗，质谱，标本分离核心（SAC），组织微阵列核心，药理学分析核心，人类免疫学，细胞处理和基因治疗，细胞治疗（GEL），生物统计学，临床研究办公室的研究药物、下一代测序、图像反应评估。

DESCRIPTION (provided by applicant): The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (SKCCC) is dedicated to research and education in cancer and related disorders and to the prompt application of new knowledge to the treatment of patients and to the prevention of neoplastic diseases. This application requests continued CCSG support for SKCCC's research programs and shared resources. The SKCCC is a multi-disciplinary, interdepartmental center of the Johns Hopkins University. There is a broad base of ongoing cancer research at Johns Hopkins. The special scientific programs of the Cancer Center are interdisciplinary in character and are focused on human disease. A wide range of activity is encompassed ranging from fundamental research into the molecular genetics of human tumorigenesis to clinical trials of new antitumor treatments. The Cancer Center has established twelve major research programs: Cancer Biology (Baylin, Velculescu), Hematologic Malignancies and BMT (Ambinder, Jones), Cancer Immunology (Pardoll), Viral Oncology (Hayward, Roden), Cancer Prevention and Control (Groopman, Platz), Chemical Therapeutics (Cole), Prostate Cancer (Carducci, Getzenberg), Breast Cancer (Stearns, Sukumar), Gastrointestinal Cancer (Jaffee, Kern) Upper Aerodigestive Cancer (Rudin, Sidransky), Brain Cancer (Grossman, Brem, Laterra), and Cancer Molecular & Functional Imaging (Bhujwalla, Pomper). Twenty-two Shared Resources support the needs of Cancer Center investigators: Animal Resources, Bioinformatics, Microarray, Cancer Functional Imaging, Cell Imaging, Common Equipment, Cytogenetics, Experimental Irradiators, Flow Cytometry, Glassware Washing, Mass Spectrometry, Specimen Accessioning Core (SAC), Tissue Microarray Core, Pharmacology Analytical Core, Human Immunology, Cell Processing and Gene Therapy, Cellular Therapy (GEL),Biostatistics, Research Pharmacy, Next Generation Sequencing, Image Response Assessment the Clinical Research Office.