Imaging Cognitive Control in Cocaine Dependence

可卡因依赖中的认知控制成像

基本信息

批准号：
8513955
负责人：
Chiang-Shan Ray Li
金额：
$ 12.78万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8513955
关键词：
Abstinence Address Algorithms Anterior Award Behavior Behavioral Binding Brain Brain region Characteristics Chronic Clinical Clinical Research Clinical Treatment Cocaine Cocaine Dependence Cognitive Conflict (Psychology)Data Development Discriminant Analysis Dorsal Drug usage Ethics Etiology Experimental Psychology Functional Magnetic Resonance Imaging Funding Gender Health Image Imaging Techniques Impairment Independent Scientist Award Inpatients Knowledge Link Logistic Regressions Maps Measures Medial Mediating Mental disorders Mentors Methodology Methods Molecular Monitor National Institute of Drug Abuse Neurosciences Occipital lobe Outcome Measure Participant Patients Performance Positron-Emission Tomography Prefrontal Cortex Principal Investigator Procedures Process Psychophysics Publications Recruitment Activity Regression Analysis Regulation Relapse Reporting Research Research Personnel Self-control as a personality trait Sensitivity and Specificity Signal Transduction Substance Use Disorder Substance abuse problem Thalamic structure Time Tissue Model Training Translational Research Treatment outcome United States National Institutes of Health Woman base blood oxygen level dependent career career development cingulate cortex cocaine exposure cocaine use cognitive control craving demographics experience follow-up hazard human subject innovation men neuromechanism neurotransmission noradrenaline transporter noradrenergic novel psychologic radioligand relating to nervous system response skills success trend

项目摘要

DESCRIPTION (provided by applicant): This K02 application seeks support that is essential for the candidate's continued training and career development in substance abuse research. With the support of mentored career awards both from the NIDA and the NIH, the candidate has developed considerable expertise in cognitive and imaging neuroscience. His has shown a record of publication in combining functional magnetic resonance imaging (fMRI) and experimental psychology to delineate the component neural processes of cognitive control, a critical factor contributing to relapse in cocaine dependent patients. He has obtained independent funding to investigate the altered neural processes of cognitive control and how these deficits may predict drug use behavior during follow-up of patients with cocaine dependence. Collaborating with colleagues at the Yale Positron Emission Tomography (PET) Center, he is also proposing to examine the molecular bases in association with altered cognitive control in these patients. Thus, the candidate has proposed a systematic training in (a) advanced data including connectivity analysis of fMRI; (b) PET imaging methodology and procedure; (c) neuropsychopharmacology; (d) clinical treatment outcome and relapse study; and (e) ethics and human subject study training to enhance his knowledge and skills in performing translational and clinical research in substance use disorders. He will acquire the expertise by focusing on three projects during the award period. In the R01 project he will elucidate the neural predictors of relapse in cocaine dependent patients. In the R03 project he will examine these neural processes in the patients with pharmacologically induced cocaine craving. He is also actively seeking funding to examine the regulation of noradrenergic neurotransmission as a molecular basis of "loss of control" during cocaine craving. Thus, this K02 award is vital for the candidate to receive additional training required to perform the proposed research, to broaden his research scope, and to remain productive in his development into a leading investigator in substance abuse research.

描述（由申请人提供）：此K02申请寻求支持，这对于候选人在药物滥用研究中的持续培训和职业发展至关重要。在NIDA和NIH的指导职业奖项的支持下，候选人在认知和成像神经科学方面已开发了相当大的专业知识。他在结合功能磁共振成像（fMRI）和实验心理学方面显示出发表记录，以描绘认知控制的成分神经过程，这是有助于可卡因患者复发的关键因素。他获得了独立的资金来研究认知控制的神经过程改变，以及这些缺陷如何预测可卡因依赖患者随访期间的药物使用行为。在耶鲁大学正电子发射断层扫描中心（PET）中心与同事合作，他还建议检查这些患者的认知控制改变的分子碱基。因此，候选人提出了（a）高级数据的系统培训，包括fMRI的连通性分析；（b）宠物成像方法和程序；（c）神经心理药理学；（d）临床治疗结果和复发研究；（e）伦理学和人类学科研究培训，以增强他在进行物质使用障碍的转化和临床研究方面的知识和技能。他将在奖励期间重点关注三个项目，从而获得专业知识。在R01项目中，他将阐明可卡因依赖性患者复发的神经预测因子。在R03项目中，他将检查药理学诱导可卡因渴望的患者的这些神经过程。他还积极寻求资金，以研究对可卡因渴望期间“失去控制”的分子基础的去甲肾上腺素能的调节。因此，这一K02奖对于候选人来说是进行拟议研究所需的额外培训，扩大其研究范围，并保持其发展效率的额外培训至关重要的至关重要的。

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Depression in chronic ketamine users: Sex differences and neural bases.

DOI：
10.1016/j.pscychresns.2017.09.001
发表时间：
2017-11-30
期刊：
Psychiatry research. Neuroimaging
影响因子：
0
作者：
Li CR;Zhang S;Hung CC;Chen CM;Duann JR;Lin CP;Lee TS
通讯作者：
Lee TS

Long noncoding RNAs in psychiatric disorders.

DOI：
10.1097/ypg.0000000000000129
发表时间：
2016-06
期刊：
Psychiatric genetics
影响因子：
0.9
作者：
Zuo L;Tan Y;Wang Z;Wang KS;Zhang X;Chen X;Li CS;Wang T;Luo X
通讯作者：
Luo X

Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence.

DOI：
10.3390/genes7110095
发表时间：
2016-11-07
期刊：
Genes
影响因子：
3.5
作者：
Zuo L;Garcia-Milian R;Guo X;Zhong C;Tan Y;Wang Z;Wang J;Wang X;Kang L;Lu L;Chen X;Li CR;Luo X
通讯作者：
Luo X

Association of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers.