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Imaging Cognitive Control in Cocaine Dependence

可卡因依赖中的认知控制成像

基本信息

批准号：
8513955
负责人：
Chiang-Shan Ray Li
金额：
$ 12.78万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8513955
关键词：
Abstinence Address Algorithms Anterior Award Behavior Behavioral Binding Brain Brain region Characteristics Chronic Clinical Clinical Research Clinical Treatment Cocaine Cocaine Dependence Cognitive Conflict (Psychology)Data Development Discriminant Analysis Dorsal Drug usage Ethics Etiology Experimental Psychology Functional Magnetic Resonance Imaging Funding Gender Health Image Imaging Techniques Impairment Independent Scientist Award Inpatients Knowledge Link Logistic Regressions Maps Measures Medial Mediating Mental disorders Mentors Methodology Methods Molecular Monitor National Institute of Drug Abuse Neurosciences Occipital lobe Outcome Measure Participant Patients Performance Positron-Emission Tomography Prefrontal Cortex Principal Investigator Procedures Process Psychophysics Publications Recruitment Activity Regression Analysis Regulation Relapse Reporting Research Research Personnel Self-control as a personality trait Sensitivity and Specificity Signal Transduction Substance Use Disorder Substance abuse problem Thalamic structure Time Tissue Model Training Translational Research Treatment outcome United States National Institutes of Health Woman base blood oxygen level dependent career career development cingulate cortex cocaine exposure cocaine use cognitive control craving demographics experience follow-up hazard human subject innovation men neuromechanism neurotransmission noradrenaline transporter noradrenergic novel psychologic radioligand relating to nervous system response skills success trend

项目摘要

DESCRIPTION (provided by applicant): This K02 application seeks support that is essential for the candidate's continued training and career development in substance abuse research. With the support of mentored career awards both from the NIDA and the NIH, the candidate has developed considerable expertise in cognitive and imaging neuroscience. His has shown a record of publication in combining functional magnetic resonance imaging (fMRI) and experimental psychology to delineate the component neural processes of cognitive control, a critical factor contributing to relapse in cocaine dependent patients. He has obtained independent funding to investigate the altered neural processes of cognitive control and how these deficits may predict drug use behavior during follow-up of patients with cocaine dependence. Collaborating with colleagues at the Yale Positron Emission Tomography (PET) Center, he is also proposing to examine the molecular bases in association with altered cognitive control in these patients. Thus, the candidate has proposed a systematic training in (a) advanced data including connectivity analysis of fMRI; (b) PET imaging methodology and procedure; (c) neuropsychopharmacology; (d) clinical treatment outcome and relapse study; and (e) ethics and human subject study training to enhance his knowledge and skills in performing translational and clinical research in substance use disorders. He will acquire the expertise by focusing on three projects during the award period. In the R01 project he will elucidate the neural predictors of relapse in cocaine dependent patients. In the R03 project he will examine these neural processes in the patients with pharmacologically induced cocaine craving. He is also actively seeking funding to examine the regulation of noradrenergic neurotransmission as a molecular basis of "loss of control" during cocaine craving. Thus, this K02 award is vital for the candidate to receive additional training required to perform the proposed research, to broaden his research scope, and to remain productive in his development into a leading investigator in substance abuse research.

描述（由申请人提供）：此K 02应用程序寻求支持，这是候选人的继续培训和职业发展在药物滥用研究必不可少的。在NIDA和NIH的指导职业奖的支持下，候选人在认知和成像神经科学方面积累了相当多的专业知识。他的研究结合了功能性磁共振成像（fMRI）和实验心理学，描绘了认知控制的组成神经过程，这是导致可卡因依赖患者复发的关键因素。他已经获得了独立的资金来研究认知控制的神经过程的改变，以及这些缺陷如何预测可卡因依赖患者随访期间的药物使用行为。与耶鲁大学正电子发射断层扫描（PET）中心的同事合作，他还建议检查与这些患者认知控制改变相关的分子基础。因此，候选人建议接受以下方面的系统培训：（a）先进数据，包括功能磁共振成像的连通性分析;（B）PET成像方法和程序;（c）神经精神药理学;（d）临床治疗结果和复发研究;（e）伦理学和人类受试者研究培训，以增强其在物质使用障碍方面进行转化和临床研究的知识和技能。他将通过在获奖期间专注于三个项目来获得专业知识。在R 01项目中，他将阐明可卡因依赖患者复发的神经预测因素。在R 03项目中，他将研究这些神经过程在患者与海洛因诱导可卡因渴望。他还积极寻求资金，以研究去甲肾上腺素能神经传递的调节作为可卡因渴望期间“失控”的分子基础。因此，这个K 02奖是至关重要的候选人接受所需的额外培训，以执行拟议的研究，扩大他的研究范围，并保持在他的发展成为一个领先的研究药物滥用研究生产力。

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Depression in chronic ketamine users: Sex differences and neural bases.

DOI：
10.1016/j.pscychresns.2017.09.001
发表时间：
2017-11-30
期刊：
Psychiatry research. Neuroimaging
影响因子：
0
作者：
Li CR;Zhang S;Hung CC;Chen CM;Duann JR;Lin CP;Lee TS
通讯作者：
Lee TS

Long noncoding RNAs in psychiatric disorders.

DOI：
10.1097/ypg.0000000000000129
发表时间：
2016-06
期刊：
Psychiatric genetics
影响因子：
0.9
作者：
Zuo L;Tan Y;Wang Z;Wang KS;Zhang X;Chen X;Li CS;Wang T;Luo X
通讯作者：
Luo X

Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence.

DOI：
10.3390/genes7110095
发表时间：
2016-11-07
期刊：
Genes
影响因子：
3.5
作者：
Zuo L;Garcia-Milian R;Guo X;Zhong C;Tan Y;Wang Z;Wang J;Wang X;Kang L;Lu L;Chen X;Li CR;Luo X
通讯作者：
Luo X

Altered resting-state functional connectivity of the insula in young adults with Internet gaming disorder.