Aging and cerebral regulation of physiological responses to social emotions

衰老和大脑对社会情绪生理反应的调节

• 批准号: 9312926
• 负责人: Chiang-Shan Ray Li
• 金额: $ 21.7万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9312926
• 关键词: Address; Adult; Affect; Affective; Age; Age-Years; Aging; Amygdaloid structure; Anterior; Anxiety; Area; Brain; Brain Stem; Brain imaging; Brain region; Cell Nucleus; Cerebrum; Cognitive; Complex; Conflict (Psychology); Conscious; Data; Elderly; Emotional; Emotions; Environment; Etiology; Evaluation; Exclusion; Exhibits; Frequencies; Fright; Functional Magnetic Resonance Imaging; Functional disorder; Galvanic Skin Response; Gender; General Population; Heart Rate; Individual; Insula of Reil; Knowledge; Light; Mathematics; Medial; Mood Disorders; Neurosciences; Neurosciences Research; Perception; Phenotype; Physiological; Prefrontal Cortex; Process; Reaction; Recruitment Activity; Regulation; Research; Signal Transduction; Social Anxiety Disorder; Social Environment; Social Interaction; Taxonomy; Temporal Lobe; Testing; Thalamic structure; Woman; Work; affective neuroscience; age effect; age group; age related; base; emotion regulation; emotional experience; emotional stimulus; experience; gender difference; healthy aging; heart rate variability; imaging study; indexing; insight; men; neural circuit; peer; positive emotional state; relating to nervous system; response; social; social anxiety; social exclusion; somatosensory

PROJECT SUMMARY Many cognitive and affective functions are preserved during aging and it has been suggested that older people are better at regulating negative emotions. Previous studies have elucidated regional brain activations in response to social emotional stimuli. However, the neural circuits regulating physiological responses to social emotions and how these processes differ between young and old people have not been explored. Emotion is represented in complex interactions between frontal limbic areas and subcortical circuits that embody physiological reactions. Emotional, compared to non-emotional, stimuli elicit robust autonomic responses congruent with interoceptive perception. Negative emotions are associated with decreased heart rate variability (HRV) and increased skin conductance level (SCL); in contrast, positive emotions are associated with increased HRV and decreased SCL. On the other hand, less is known about how cerebral activations to emotional stimuli in a social context are related to autonomic responses. No studies have examined the causal relationship between cerebral activities and autonomic responses to social emotional stimulation or the effects of aging on these regulatory activities. This R21 application aims to address these gaps of research. We will assess and recruit young and old adults to participate in brain imaging while exposed to social emotions. We will examine (a) whether and how social, compared to neutral, emotion scenarios, evoke changes in HRV and SCL, and how these changes vary between young and old individuals; and (b) how regional responses to social emotions correlate with and Granger cause HRV and SCL, building on our work of Granger causality analysis, and how these regulatory activities vary between young and old individuals. We will also explore how autonomic responses, regional activations to social emotional stimulation and their regulation of autonomic responses relate to social anxiety as well as age and gender effects on the relations. Together, the study will elucidate cerebral responses to social emotions, how regional and circuit activities regulate physiological responses to social emotions, and the influence of aging on these neural regulatory activities. The potential findings may advance our knowledge of the effects of aging on emotional experience and move aging and affective neuroscience research in new directions.

项目摘要 在衰老期间保留了许多认知和情感功能，并有人提出老年人 更好地调节负面情绪。先前的研究已经阐明了区域大脑的激活 对社交情感刺激的反应。但是，神经回路调节对社会的生理反应 尚未探索年轻人和老年人之间的情绪以及这些过程的不同。 情绪在额叶边缘区域和皮层下电路之间的复杂相互作用中表示 体现生理反应。与非情感刺激相比，情绪激发了强大的自主神经 响应与感受性的感知一致。负面情绪与心脏减少有关 速率变异性（HRV）和皮肤电导水平增加（SCL）；相反，积极的情绪是 与HRV增加并减少SCL有关。另一方面，对脑的了解很少 在社会环境中激活情绪刺激与自主反应有关。没有研究 研究了脑活动与对社会情感的自主反应之间的因果关系 刺激或衰老对这些调节活动的影响。此R21应用程序旨在解决这些问题 研究差距。 我们将评估和招募年轻人和老年人参加大脑成像，同时接触社交 情绪。我们将研究（a）与中立，情感场景相比，社交是否以及如何唤起社会 HRV和SCL的变化以及这些变化在年轻人和老年人之间的变化各不相同； （b）如何 社会情感的区域反应与Granger相关，并引起HRV和SCL，以我们的工作为基础 Granger因果关系分析以及这些监管活动在年轻人和老年人之间如何有所不同。我们将 还探讨了自主性反应，社会情绪刺激的区域激活及其调节 自主反应与社交焦虑以及年龄和性别对关系的影响有关。 该研究将共同​​阐明对社会情绪的脑反应，区域和电路活动的方式 调节对社会情绪的生理反应，以及衰老对这些神经调节的影响 活动。潜在的发现可能会提高我们对衰老对情感体验的影响的了解 并在新方向上移动衰老和情感神经科学研究。