Aging and cerebral regulation of physiological responses to social emotions

衰老和大脑对社会情绪生理反应的调节

• 批准号: 9312926
• 负责人: Chiang-Shan Ray Li
• 金额: $ 21.7万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9312926
• 关键词: Address; Adult; Affect; Affective; Age; Age-Years; Aging; Amygdaloid structure; Anterior; Anxiety; Area; Brain; Brain Stem; Brain imaging; Brain region; Cell Nucleus; Cerebrum; Cognitive; Complex; Conflict (Psychology); Conscious; Data; Elderly; Emotional; Emotions; Environment; Etiology; Evaluation; Exclusion; Exhibits; Frequencies; Fright; Functional Magnetic Resonance Imaging; Functional disorder; Galvanic Skin Response; Gender; General Population; Heart Rate; Individual; Insula of Reil; Knowledge; Light; Mathematics; Medial; Mood Disorders; Neurosciences; Neurosciences Research; Perception; Phenotype; Physiological; Prefrontal Cortex; Process; Reaction; Recruitment Activity; Regulation; Research; Signal Transduction; Social Anxiety Disorder; Social Environment; Social Interaction; Taxonomy; Temporal Lobe; Testing; Thalamic structure; Woman; Work; affective neuroscience; age effect; age group; age related; base; emotion regulation; emotional experience; emotional stimulus; experience; gender difference; healthy aging; heart rate variability; imaging study; indexing; insight; men; neural circuit; peer; positive emotional state; relating to nervous system; response; social; social anxiety; social exclusion; somatosensory

PROJECT SUMMARY Many cognitive and affective functions are preserved during aging and it has been suggested that older people are better at regulating negative emotions. Previous studies have elucidated regional brain activations in response to social emotional stimuli. However, the neural circuits regulating physiological responses to social emotions and how these processes differ between young and old people have not been explored. Emotion is represented in complex interactions between frontal limbic areas and subcortical circuits that embody physiological reactions. Emotional, compared to non-emotional, stimuli elicit robust autonomic responses congruent with interoceptive perception. Negative emotions are associated with decreased heart rate variability (HRV) and increased skin conductance level (SCL); in contrast, positive emotions are associated with increased HRV and decreased SCL. On the other hand, less is known about how cerebral activations to emotional stimuli in a social context are related to autonomic responses. No studies have examined the causal relationship between cerebral activities and autonomic responses to social emotional stimulation or the effects of aging on these regulatory activities. This R21 application aims to address these gaps of research. We will assess and recruit young and old adults to participate in brain imaging while exposed to social emotions. We will examine (a) whether and how social, compared to neutral, emotion scenarios, evoke changes in HRV and SCL, and how these changes vary between young and old individuals; and (b) how regional responses to social emotions correlate with and Granger cause HRV and SCL, building on our work of Granger causality analysis, and how these regulatory activities vary between young and old individuals. We will also explore how autonomic responses, regional activations to social emotional stimulation and their regulation of autonomic responses relate to social anxiety as well as age and gender effects on the relations. Together, the study will elucidate cerebral responses to social emotions, how regional and circuit activities regulate physiological responses to social emotions, and the influence of aging on these neural regulatory activities. The potential findings may advance our knowledge of the effects of aging on emotional experience and move aging and affective neuroscience research in new directions.

项目摘要 许多认知和情感功能在衰老过程中得以保留， 更擅长调节负面情绪以前的研究已经阐明了大脑的局部激活， 对社会情绪刺激的反应。然而，调节对社交活动的生理反应的神经回路 情绪以及这些过程在年轻人和老年人之间的差异还没有被探索过。 情绪表现在额叶边缘区和皮层下回路之间复杂的相互作用中， 体现生理反应。与非情绪性刺激相比，情绪性刺激会引发强烈的自主神经功能。 与内感受性知觉一致的反应。负面情绪与心脏功能下降有关 心率变异性（HRV）和皮肤电导水平（SCL）增加;相反，积极情绪 与HRV升高和SCL降低相关。另一方面，我们对大脑的 在社会环境中对情绪刺激的激活与自主反应有关。没有研究 研究了大脑活动与社会情绪自主反应之间的因果关系， 刺激或老化对这些调节活动的影响。此R21应用程序旨在解决这些问题 研究的差距。 我们将评估和招募年轻人和老年人参加大脑成像，同时暴露于社会 情绪我们将研究（a）与中性情感情景相比，社会情感情景是否以及如何唤起 HRV和SCL的变化，以及这些变化在年轻人和老年人之间如何变化;以及（B）如何 社会情绪的区域反应与HRV和SCL相关，格兰杰导致HRV和SCL，建立在我们的工作， 格兰杰因果关系分析，以及这些调节活动如何在年轻和老年个体之间变化。我们将 并探讨自主反应，区域激活社会情绪刺激和他们的调节 自主神经反应与社交焦虑的关系以及年龄和性别的影响。 总之，这项研究将阐明大脑对社会情绪的反应，区域和回路活动如何影响大脑的活动。 调节社会情绪的生理反应，以及衰老对这些神经调节的影响。 活动这些潜在的发现可能会促进我们对衰老对情感体验影响的认识 并将衰老和情感神经科学研究推向新的方向。