Cerebral Correlates of Early Habitual Drinking

早期习惯性饮酒的大脑相关性

• 批准号: 8901746
• 负责人: Chiang-Shan Ray Li
• 金额: $ 22.89万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-05 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8901746
• 关键词: Address; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcoholic beverage heavy drinker; Alcohols; Anterior; Behavior; Behavioral; Biological Markers; Brain; Brain imaging; Cerebrum; Clinical; Clinical assessments; Corpus striatum structure; Data; Development; Diffusion Magnetic Resonance Imaging; Early Intervention; Environment; Etiology; Frequencies; Functional Magnetic Resonance Imaging; Future; Genetic; Genetic study; Glucuronides; Goals; Grant; Hair; Head; Heavy Drinking; Image; Impulsivity; Individual; Light; Magnetic Resonance Imaging; Measures; Medial; Mediating; Medical; National Institute on Alcohol Abuse and Alcoholism; Neural Pathways; Participant; Pathway interactions; Personality Traits; Phenotype; Prefrontal Cortex; Process; Psychological Factors; Recruitment Activity; Reporting; Research; Risk; Risk Factors; Risk-Taking; Sampling; Structure; Substance of Abuse; Time; Visit; Woman; alcohol craving; alcohol cue; alcohol expectancy; alcohol misuse; base; chronic alcohol ingestion; cognitive control; cue reactivity; drinking; drinking behavior; early drinking; endophenotype; follow-up; gray matter; indexing; men; morphometry; neural correlate; problem drinker; prospective; public health relevance; relating to nervous system; response; social; volunteer; white matter

DESCRIPTION (provided by applicant): Early and habitual alcohol use is prodromal to alcohol dependence. Multiple factors including genetics and environment contribute to early and habitual drinking. Numerous studies have suggested cerebral structures and functions as an intermediate phenotype of alcohol misuse and vulnerability to alcohol dependence. On the other hand, while there is abundant information on how cerebral structures and functions are altered as a result of chronic alcohol use, little is known about these influences in non-dependent early and habitual drinking. In particular, what are the neural correlates that would predict increase in problem drinking and the quantity and frequency of alcohol use in non-dependent individuals? To address this question, we propose to recruit a large sample of early alcohol drinkers for magnetic resonance imaging (MRI) studies and clinical follow-up. Volunteers will undergo detailed medical and psychiatric assessments including their drinking behaviors, participate in MRI studies to evaluate cerebral structures (voxel-based morphometry or VBM), white matter integrity (diffusion tensor imaging or DTI), and functions of the component processes of cognitive control and alcohol cue reactivity (functional MRI or fMRI). We will engage all participants in a two-year clinical follow-up with tri-monthly assessments of their drinking behaviors. Head hair ethyl glucuronide will be quantified at baseline and every other follow-up, as a complementary index of alcohol consumption. For each of these neural measures, we will examine how they predict changes in drinking behavior, both independently and synergistically. Our overarching goal is to identify cerebral endophenotypes that best describe non-dependent early, habitual drinking and predict changes in problem drinking as well as the frequency and quantity of drinking. The potential findings would characterize the circuit biomarkers of early habitual drinking at a level of details that are critically needed and yet not currently available. Most importantly, these neural markers would help identify and facilitate early intervention for individuals at risk of developing heavy drinking and alcohol dependence.

描述（由申请人提供）：早期和习惯性饮酒是酒精依赖的前驱症状。包括遗传和环境在内的多种因素导致过早和习惯性饮酒。大量研究表明，大脑结构和功能是酒精滥用和酒精依赖易感性的中间表型。另一方面，虽然有大量关于长期饮酒如何改变大脑结构和功能的信息，但对非依赖性早期和习惯性饮酒的影响知之甚少。特别是，哪些神经关联会预测增加