Cerebral Correlates of Early Habitual Drinking

早期习惯性饮酒的大脑相关性

• 批准号: 8503268
• 负责人: Chiang-Shan Ray Li
• 金额: $ 24.53万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-05 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8503268
• 关键词: Address; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcoholic beverage heavy drinker; Alcohols; Anterior; Behavior; Behavioral; Biological Markers; Brain; Brain imaging; Cerebrum; Clinical; Clinical assessments; Corpus striatum structure; Data; Development; Diffusion Magnetic Resonance Imaging; Early Intervention; Environment; Etiology; Frequencies; Functional Magnetic Resonance Imaging; Future; Genetic; Glucuronides; Goals; Grant; Hair; Head; Heavy Drinking; Image; Impulsivity; Individual; Light; Magnetic Resonance Imaging; Measures; Medial; Mediating; Medical; National Institute on Alcohol Abuse and Alcoholism; Neural Pathways; Participant; Pathway interactions; Personality Traits; Phenotype; Prefrontal Cortex; Process; Psychological Factors; Recruitment Activity; Reporting; Research; Risk; Risk Factors; Risk-Taking; Sampling; Structure; Substance of Abuse; Time; Visit; Woman; alcohol craving; alcohol cue; alcohol expectancy; alcohol misuse; base; chronic alcohol ingestion; cognitive control; cue reactivity; drinking; drinking behavior; early drinking; endophenotype; follow-up; gray matter; indexing; men; morphometry; problem drinker; prospective; public health relevance; relating to nervous system; response; social; volunteer; white matter

DESCRIPTION (provided by applicant): Early and habitual alcohol use is prodromal to alcohol dependence. Multiple factors including genetics and environment contribute to early and habitual drinking. Numerous studies have suggested cerebral structures and functions as an intermediate phenotype of alcohol misuse and vulnerability to alcohol dependence. On the other hand, while there is abundant information on how cerebral structures and functions are altered as a result of chronic alcohol use, little is known about these influences in non-dependent early and habitual drinking. In particular, what are the neural correlates that would predict increase in problem drinking and the quantity and frequency of alcohol use in non-dependent individuals? To address this question, we propose to recruit a large sample of early alcohol drinkers for magnetic resonance imaging (MRI) studies and clinical follow-up. Volunteers will undergo detailed medical and psychiatric assessments including their drinking behaviors, participate in MRI studies to evaluate cerebral structures (voxel-based morphometry or VBM), white matter integrity (diffusion tensor imaging or DTI), and functions of the component processes of cognitive control and alcohol cue reactivity (functional MRI or fMRI). We will engage all participants in a two-year clinical follow-up with tri-monthly assessments of their drinking behaviors. Head hair ethyl glucuronide will be quantified at baseline and every other follow-up, as a complementary index of alcohol consumption. For each of these neural measures, we will examine how they predict changes in drinking behavior, both independently and synergistically. Our overarching goal is to identify cerebral endophenotypes that best describe non-dependent early, habitual drinking and predict changes in problem drinking as well as the frequency and quantity of drinking. The potential findings would characterize the circuit biomarkers of early habitual drinking at a level of details that are critically needed and yet not currently available. Most importantly, these neural markers would help identify and facilitate early intervention for individuals at risk of developing heavy drinking and alcohol dependence.

描述（由申请人提供）：早期和习惯性饮酒是酒精依赖的前兆。遗传和环境等多种因素导致早期饮酒和习惯性饮酒。大量研究表明，大脑结构和功能是酒精滥用和酒精依赖脆弱性的中间表型。另一方面，虽然有大量关于长期饮酒如何改变大脑结构和功能的信息，但人们对这些对非依赖性早期和习惯性饮酒的影响知之甚少。特别是，预测增加的神经相关因素是什么？ 非受抚养人的饮酒问题以及饮酒的数量和频率？ 为了解决这个问题，我们建议招募大量早期饮酒者样本进行磁共振成像（MRI）研究和临床随访。志愿者将接受详细的医学和精神评估，包括饮酒行为，参与 MRI 研究以评估大脑结构（基于体素的形态测量或 VBM）、白质完整性（弥散张量成像或 DTI）以及认知控制和酒精提示反应的组成过程的功能（功能 MRI 或 fMRI）。我们将让所有参与者参与为期两年的临床随访，每三个月评估一次他们的饮酒行为。头发乙基葡萄糖醛酸将在基线和其他后续随访中进行量化，作为酒精消耗的补充指标。对于这些神经测量中的每一个，我们将研究它们如何独立和协同地预测饮酒行为的变化。 我们的首要目标是确定最能描述非依赖性早期习惯性饮酒的大脑内表型，并预测饮酒问题以及饮酒频率和数量的变化。潜在的发现将在迫切需要但目前尚不可用的细节水平上描述早期习惯性饮酒的循环生物标志物。 最重要的是，这些神经标记将有助于识别和促进对有酗酒和酒精依赖风险的个体进行早期干预。