Biostatistics and Bioinformatics Core

生物统计和生物信息学核心资源将提供全面的生物统计和 为拟议中的Johns Hopikins Head and Neck的所有项目提供生物信息学咨询和合作 孢子。此外，它还将为数据存储、信息学和计算提供支持，并协助 识别和解决项目活动过程中出现的复杂数据任务。核心成员将 与项目调查人员在广泛的活动中合作，包括数据获取(包括 研究设计、目标的可行性、可供公众获取的基因组信息和数据存储)， 统计质量控制(包括人工产物检测和基因组技术数据的预处理)， 数据分析(包括可视化、生物统计建模和手稿写作辅助)，以及 如果需要，开发创新的定制生物统计和生物信息学方法和工具 具体项目。拟议的头和颈部孢子生物统计核心将设在 肿瘤科肿瘤学生物统计学/生物信息学，这是一个积极和致力于 生物统计学和生物信息学教职员工，拥有最先进的设备和广泛的 一系列专业知识。此核心资源是现有资源的延续，具有原始和 约翰·霍普金斯大学目前的头颈部孢子项目。核心成员坚定地致力于 这个孢子，源于(I)与这一事件以及其他案件的调查人员的合作历史 孢子项目，(2)积极和独立资助的协同项目议程，和(3)a 对生物社会学和分析性问题和挑战表现出兴趣和理解。全 预计拟议的项目将在每个目标中利用这一资源。

The Biostatistics and Bioinformatics Core resource will provide comprehensive biostatistics and bioinformatics consultation and collaboration to all projects in the proposed Johns Hopikins Head and Neck SPORE. In addition, it will provide support for data storage, informatics, and computing, and assist with the identification and solution of complex data tasks arising in the course of project activities. Core members will work with project investigators across a wide spectrum of activities, encompassing data acquisition (including study design, feasibility of objectives, availability of public-access genomic information, and data storage), statistical quality control (including artifact detection and preprocessing of data from genomic technologies), data analysis (including visualization, biostatistical modeling, and assistance with manuscript writing), and development of innovative customized biostatistics and bioinformatics methodologies and tools if required by specific projects. The proposed Head and Neck SPORE Biostatistics Core will be housed in the Division of Oncology Biostatistics/Bioinformatics of the Department of Oncology, an active and committed group of the biostatistics and bioinformatics faculty members, with access to state-of-the-art equipment and a broad range of expertise. This Core resource is the continuation of an existing resource wthin the original and current Head and Neck SPORE program at Johns Hopkins. Core members have a strong commitment to this SPORE, stemming from (i) a history of collaboration with the investigators ofthis as well as other SPORE projects, (ii) an active and independentiy funded agenda of synergistic projects, and (iii) a demonstrated interest and understanding of both the biologocial and analytical questions and challenges. All proposed projects are anticipated to make use ofthis resource in every aim.