Neural mechanisms of motor adaptation for an internally driven movement

内部驱动运动的运动适应神经机制

• 批准号: 10417657
• 负责人: Yoshiko Kojima
• 金额: $ 45.78万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10417657
• 关键词: Address; Aging; Behavioral; Brain; Calibration; Characteristics; Cognitive; Cues; Disease; Error Sources; Exhibits; Fingers; Goals; Growth; Injury; Knowledge; Life; Location; Memory; Motor; Movement; Muscle; Nervous System; Neuronal Plasticity; Neurons; Outcome; Patients; Plants; Play; Positioning Attribute; Property; Role; Saccades; Short-Term Memory; Signal Transduction; Site; Structure; System; Time; Visual; Visual impairment; Visuospatial; Work; experimental study; gaze; improved; innovation; interest; member; neural; neuromechanism; rapid eye movement; rehabilitation strategy; response; superior colliculus Corpora quadrigemina; vector; visual stimulus

Project Summary/Abstract The object of interest is not always visible at the time of movement. Visuospatial working memory plays an essential role in directing movements in such situations. This system stores the position of an object in the visual world and can be used to direct a movement to engage it. This is an internally driven movement. In contrast, we make so-called externally cued movement when the object is visible at the time of movement. To make movements accurate in both situations, visuospatial working memory and the visual signal need to be appropriately transformed to a motor command signal. The mechanism that maintains the motor accuracy is called motor adaptation. The behavioral characteristics and neural mechanisms of motor adaptation for an externally cued movement are well understood, however, little is known about motor adaptation of an internally driven movement. Do adaptations for both types of movement engage the same neural mechanism? If they are different, how are they different in their behavioral characteristics and neural mechanisms, and do they interact? We will use saccadic eye movements to study motor adaptation. Saccades, rapid eye movements that direct the gaze to targets of interest, can be induced by an external visual signal (visually-guided saccade, VGS) or by an internal visuospatial working memory (memory-guided saccade, MGS). Also, saccades are very precise. Because saccades remain accurate throughout life, despite the neural and muscular changes due to aging or injury, the saccadic system must be continually recalibrated through saccade adaptation. When we examined the VGS after MGS adaptation, VGS remained unchanged. Therefore, we hypothesize that the neural mechanism for MGS adaptation is distinct from that for VGS adaptation. In this project, we propose to investigate the adaptation of MGS and compare it with that of VGS. The main innovation of this study is that it could reveal a yet unknown motor adaptation mechanism for internally driven movement. The innovative concept is that the neural basis of motor adaptation for internally and externally driven movements could be separate but interact. Understanding the neuronal basis of motor adaptation for both externally and internally driven movements will provide a comprehensive picture of motor adaptation.

项目摘要/摘要 在移动时，感兴趣的对象并不总是可见的。视觉空间工作记忆播放 在这种情况下指导运动的重要作用。该系统将对象的位置存储在 视觉世界，可用于指导运动以吸引它。这是一个内部驱动的运动。在 对比，当物体在移动时可见时，我们会进行所谓的外部提示运动。到 在两种情况下，视觉空间工作记忆和视觉信号都需要使运动准确 适当地转换为电动机命令信号。 维持电动机精度的机制称为电动机适应。行为 运动适应的特征和神经机制，用于外部提示运动很好 然而，人们对内部驱动运动的运动适应性知之甚少。进行改编 对于这两种运动，都具有相同的神经机制？如果它们与众不同，它们在 它们的行为特征和神经机制，它们是否相互作用？ 我们将使用Saccadic眼动运动来研究运动适应。扫视，直接的快速移动 可以通过外部视觉信号（视觉引导的扫视，VG）或 通过内部视觉空间工作记忆（内存引导的扫视，MGS）。而且，扫视非常精确。 由于扫视在一生中保持准确，尽管由于衰老或 损伤，必须通过扫视适应来不断重新校准囊泡系统。 当我们在MGS适应后检查VG时，VG保持不变。因此，我们假设 MGS适应的神经机制与VG适应的神经机制不同。在这个项目中，我们 建议研究MGS的适应并将其与VG的适应性进行比较。 这项研究的主要创新是它可以揭示一种但未知的电机适应机制 内部驱动的运动。创新的概念是运动适应的神经基础 外部驱动的运动可能是分开但相互作用的。了解电机的神经元基础 对外部和内部驱动的动作的适应将为电动机提供全面的了解 适应。