权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Measuring gene-environment transactions to identify sensitive periods for infant social behavior & brain growth

测量基因-环境变化以确定婴儿社会行为的敏感期

基本信息

批准号：
10355527
负责人：
Warren Jones
金额：
$ 73.48万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-02 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10355527
关键词：
Accounting Adolescence Affect Age Atlases Behavioral Behavioral Genetics Biological Birth Brain Child Child Development Competence Data Development Developmental Course Dizygotic Twins Ecosystem Elderly Enrollment Environment Future Genes Genetic Genetic Variation Genetic study Growth Human Individual Infant Intervention Laboratories Learning Life Magnetic Resonance Imaging Measures Modeling Monozygotic twins Nature Neurodevelopmental Disability Pathway interactions Pattern Personality Phenotype Process Research Shapes Social Behavior Social Development Standardization Testing Therapeutic Time Transact Twin Multiple Birth Variant Visual Walking autism spectrum disorder autistic children behavior change clinically significant cognitive ability cohort disability early childhood experience improved infancy insight neuroimaging preempt prevent prospective psychologic social social learning spatiotemporal standardize measure visual tracking

项目摘要

PROJECT SUMMARY/ABSTRACT This project builds on recent research in our laboratory that showed for the first time that genes directly shape the way a child sees the world: what a child spends time looking at—as well as how, when, and where she looks—are all strongly influenced by genetic variation (Constantino et al, Nature, 2017). Identical twins, who share the same genetic variation, effectively synchronize their looking to social content. Moreover, these same measures of social looking are markedly and differentially decreased in children with autism spectrum disorder (ASD) (Χ2= 64.03, P < 0.0001). In the current project, we will measure genetic and environmental influence on social visual engagement and brain growth from birth through toddlerhood, quantifying effects of gene- environment transactions over time. We will use eye-tracking to measure how infants look at the social world and MRI to measure changing brain connectivity under conditions of controlled genetic variation: identical & fraternal twins followed from the first week after birth. We will enroll 240 twins (120 pairs), collecting eye- tracking data at 10 time points, neuroimaging data at 5 time points, and standardized assessments of social- communicative competency at 3 time points. This application will test the hypothesis that gene-by- environment-by-age transactions in the first years of life serve as a powerful developmental canalizing mechanism, a mechanism capable of providing the necessary shared medium for typical social development, and yet equally capable of channeling diverse initial liabilities off-course, into atypical social development resulting in the syndromic social disability called autism spectrum disorder. By quantifying the developmental timing of gene-environment transactions, together with their impact on phenotypic presentation of social behavior and brain growth, this project will provide insights into modifiable behavioral pathways that offer the greatest therapeutic potential to prevent or preempt the emergence of deleterious consequences of atypical development as found in ASD and other neurodevelopmental disabilities.

项目总结/文摘