Maternal Depression Calibrates Infants' Neuroendocrine, Autonomic, and Inflammatory Stress Responsiveness
母亲抑郁症可调节婴儿的神经内分泌、自主神经和炎症应激反应
基本信息
- 批准号:10401874
- 负责人:
- 金额:$ 58.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-03 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdrenal GlandsAgeAutonomic nervous systemBehaviorBiologicalCalibrationChildChild DevelopmentChronicClinicalCommunitiesDepressive disorderDevelopmentDiagnosisDiagnosticDiseaseEarly InterventionEmotionalEmotionsExposure toFosteringGoalsHealthHydrocortisoneHypothalamic structureInfantInflammation MediatorsInflammatoryInformal Social ControlInterleukin-6InterruptionInterventionInvestigationKnowledgeLife ExperienceLinkMediator of activation proteinMental DepressionMental HealthMental disordersModelingMothersNeurosecretory SystemsOutcomeParentsPatternPersonsPhysiologicalPhysiologyPituitary GlandPregnancyPregnant WomenProblem behaviorPsychopathologyRegulationReportingResearchResearch Project GrantsRestRiskRisk MarkerSalivarySamplingSeveritiesShapesStressSymptomsSystemSystems DevelopmentTNF geneTestingTimeToddlerTranslatingalpha-amylasebehavior measurementbiological adaptation to stressdepressive symptomsearly childhoodemotion regulationexecutive functionfollow-uphypothalamic-pituitary-adrenal axisinfancyinsightintergenerationalmaternal depressionnoveloffspringpostnatalprenatalpsychosocial adjustmentrecruitresponsesingle episode major depressive disorderstress related disorderstress resiliencestressortransmission process
项目摘要
PROJECT SUMMARY
The objective of the current proposal is to determine when and how infants' stress responsivity is calibrated by
maternal depression, and how this calibration translates into child emotional and behavioral problems.
Psychological health relies on the regulation of stress-responsive physiological systems—i.e., hypothalamic-
pituitary-adrenal (HPA) axis, autonomic nervous system (ANS), and inflammatory mediator (IM) responses
that match the demands of a given stressor and recover promptly once it has passed. It is important to clarify
how these systems become dysregulated in order to identify and intervene on risk trajectories. Previous cross-
sectional research highlights maternal predictors and child outcomes related to dysregulation of one or more of
these systems but fails to address the possibility that within-person development of stress responsivity across
systems offers a critical window into early risk. We will test the central hypothesis that early exposure
to maternal depression predicts sensitization of HPA, ANS, and/or IM function that
undermines the child's psychological health through the following specific aims: (1) Determine whether
maternal depression induces upward calibration of infant stress responsivity across systems; (2) Identify
maternal depression profiles with the strongest impact on infant stress calibration; and (3) [Characterize
maladaptive stress system development through associations between infant stress response trajectories and
deficits in self-regulatory functions.] A community sample of [250 expectant mothers—over half with a
diagnosed major depressive episode and the rest with no diagnoses]—will be recruited during pregnancy and
followed through the first 2 postnatal years. At 3, 8, 15, and 24 months the infant will be exposed to
developmentally appropriate interpersonal stressors to assess stress responsivity, with salivary cortisol tapping
HPA, alpha-amylase (sAA) tapping ANS, and a composite of IL-1b, IL-6, TNF-a, and CRP tapping IM
activation. Child self-regulatory development will be assessed via both mother-report and behavioral measures
at 24 months. We hypothesize that mothers' depression symptoms will predict child stress sensitization from
3-24 months, evidenced by a trajectory of increasing/nonrecovering multi-system activation over time. The
strongest effects are expected for early (prenatal, 3-month postnatal) depression symptoms in mothers who
have crossed a diagnostic threshold for a lifetime depressive disorder. We further expect child stress
sensitization—[especially high/increasing concordant activation across HPA and IM, but low/decreasing
concordance across HPA and ANS]—will predict poorer executive function and emotion regulation at 24
months. Achieving these aims will clarify how stress-responsive systems are calibrated by maternal depression
and how this calibration confers risk for later disorder. The findings will inform a truly developmental model of
stress-related dysregulation while defining novel stress physiology targets for early mother/infant intervention
to mitigate psychological health risks in children of depressed mothers.
项目摘要
目前建议的目的是确定婴儿的压力反应何时以及如何校准,
母亲抑郁症,以及这种校准如何转化为儿童情绪和行为问题。
心理健康依赖于应激反应生理系统的调节,即,下丘脑的
垂体-肾上腺(HPA)轴、自主神经系统(ANS)和炎症介质(IM)反应
它能满足特定压力源的需求,并在压力源消失后迅速恢复。有必要澄清
这些系统如何变得失调,以识别和干预风险轨迹。前交叉-
部分研究强调了与一种或多种调节障碍有关的孕产妇预测因素和儿童结局,
这些系统,但未能解决的可能性,在人的发展压力反应,
系统为早期风险提供了一个关键窗口。我们将检验中心假设,即早期接触
母亲抑郁症预测HPA,ANS和/或IM功能的敏感化,
通过以下具体目的破坏儿童的心理健康:(1)确定是否
母亲抑郁症引起婴儿压力反应在系统中的向上校准;(2)识别
对婴儿压力校准影响最大的母亲抑郁特征;以及(3)[表征
通过婴儿应激反应轨迹与
自我调节功能的缺陷]。一个社区样本[250名孕妇-超过一半的孕妇
诊断为重度抑郁发作,其余未诊断]-将在怀孕期间招募,
在出生后的前两年进行随访。在3个月、8个月、15个月和24个月时,婴儿将暴露于
发展适当的人际压力,以评估压力反应,唾液皮质醇轻拍
HPA、α-淀粉酶(sAA)标记ANS,以及IL-1b、IL-6、TNF-α和CRP标记IM的复合物
activation.儿童自我调节的发展将通过母亲报告和行为措施进行评估
在24个月的时候。我们假设,母亲的抑郁症状将预测儿童的压力敏感性,
3-24月,证明了随着时间的推移,多系统激活的增加/不可恢复的轨迹。的
最强的影响,预计早期(产前,产后3个月)抑郁症状的母亲,
已经超过了终生抑郁症的诊断门槛我们进一步预计儿童压力
致敏-[HPA和IM的一致性激活特别高/增加,但低/降低
HPA和ANS之间的一致性]-将预测24岁时执行功能和情绪调节较差
个月实现这些目标将阐明压力反应系统是如何被母亲抑郁校准的
以及这种校准是如何赋予日后紊乱的风险的。这些发现将为一个真正的发展模型提供信息,
压力相关的失调,同时为早期母婴干预定义新的压力生理学目标
减轻抑郁母亲的孩子的心理健康风险。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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HEIDEMARIE KAISER LAURENT其他文献
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{{ truncateString('HEIDEMARIE KAISER LAURENT', 18)}}的其他基金
Maternal Depression Calibrates Infants' Neuroendocrine, Autonomic, and Inflammatory Stress Responsiveness
母亲抑郁症可调节婴儿的神经内分泌、自主神经和炎症应激反应
- 批准号:
9754851 - 财政年份:2018
- 资助金额:
$ 58.11万 - 项目类别:
Maternal Depression Calibrates Infants' Neuroendocrine, Autonomic, and Inflammatory Stress Responsiveness
母亲抑郁症可调节婴儿的神经内分泌、自主神经和炎症应激反应
- 批准号:
9524011 - 财政年份:2018
- 资助金额:
$ 58.11万 - 项目类别:
Maternal Depression Calibrates Infants' Neuroendocrine, Autonomic, and Inflammatory Stress Responsiveness
母亲抑郁症可调节婴儿的神经内分泌、自主神经和炎症应激反应
- 批准号:
10531793 - 财政年份:2018
- 资助金额:
$ 58.11万 - 项目类别:
Mapping Neural Response to Infant Distress in Depressed New Mothers
绘制抑郁新妈妈对婴儿窘迫的神经反应
- 批准号:
7693809 - 财政年份:2008
- 资助金额:
$ 58.11万 - 项目类别:
Mapping Neural Response to Infant Distress in Depressed New Mothers
绘制抑郁新妈妈对婴儿窘迫的神经反应
- 批准号:
7612335 - 财政年份:2008
- 资助金额:
$ 58.11万 - 项目类别:
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