Mapping Neural Response to Infant Distress in Depressed New Mothers

绘制抑郁新妈妈对婴儿窘迫的神经反应

基本信息

  • 批准号:
    7693809
  • 负责人:
  • 金额:
    $ 5.12万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-09-16 至 2010-09-15
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The long-term objective of this research is to elucidate the biosocial mechanisms involved in the etiology and impact of perinatal depression (PD) by linking early deficits in mother-infant coregulation to specific patterns of brain/neuroendocrine development that confer vulnerability to emotional dysregulation in the face of life stressors such as pregnancy and parenthood. These insights will be used to highlight women at risk for PD and to inform psychosocial and/or pharmacological treatment targets that block the transmission of depression risk. The immediate goal of this study is to test the hypothesis that PD mothers are distinguished by impaired emotion regulation in the context of their infant's distress at several interrelated levels of response: neural, neuroendocrine, and behavioral. To achieve this goal, I propose to 1) compare PD and non-PD mothers' patterns of neural response to their own infants' distress signals, 2) relate these patterns to mothers' hypothalamic-pituitary-adrenal (HPA) axis activity, and 3) relate these patterns to mothers' observed sensitivity to their infant. For this preliminary study, primiparous mothers who either show elevated depression across the perinatal period (PD group) or consistently low depression (non-PD group) are exposed to cry recordings and cry face images from their own and unfamiliar infants while undergoing functional neuroimaging. Contrasts between BOLD activity in different conditions (e.g., own vs. unfamiliar infant cry) will test response patterns within mothers/groups, as well as differences in response between PD and non-PD mothers. Mothers' salivary cortisol levels (indexing HPA activity) and behavioral sensitivity scores (both from a separate postnatal assessment) will also be entered as predictors of neural response to test brain-hormone-behavior associations in PD. PUBLIC HEALTH RELEVANCE: This research is important for public health because of the high cost of perinatal depression (PD), not only for the mother, but also for her infant's future development and mental health risk. However, the neurobiological basis for PD and its effects on the mother-infant dyad are not well understood. By identifying the patterns of neural response that distinguish perinatally depressed mothers and their relationship to aspects of behavioral and neuroendocrine dysregulation shown to harm the infant, we will be able to better characterize who is at risk and why, allowing for the development of more precise and efficacious treatment targets that will reduce the propagation of disorder.
描述(由申请人提供):本研究的长期目标是通过将母婴协同调节的早期缺陷与大脑/神经内分泌发育的特定模式联系起来,阐明围产期抑郁症(PD)的病因和影响所涉及的生物社会机制,这些模式在面对生活压力(如怀孕和为人父母)时易受情绪失调的影响。这些见解将用于突出有PD风险的女性,并为阻断抑郁风险传播的心理社会和/或药物治疗目标提供信息。本研究的直接目标是检验这一假设,即PD母亲的区别受损的情绪调节的背景下,他们的婴儿的痛苦在几个相互关联的反应水平:神经,神经内分泌和行为。为了实现这一目标,我建议1)比较PD和非PD母亲对自己婴儿的痛苦信号的神经反应模式,2)将这些模式与母亲的下丘脑-垂体-肾上腺(HPA)轴活动联系起来,3)将这些模式与母亲观察到的对婴儿的敏感性联系起来。在这项初步研究中,在围产期(PD组)或持续低抑郁(非PD组)表现出抑郁升高的母亲在接受功能性神经成像时暴露于自己和不熟悉婴儿的哭泣录音和哭泣面部图像。不同条件下BOLD活性之间的对比(例如,自己的婴儿哭声与不熟悉的婴儿哭声)将测试母亲/组内的反应模式,以及PD和非PD母亲之间的反应差异。母亲的唾液皮质醇水平(指示HPA活性)和行为敏感性评分(均来自单独的产后评估)也将作为神经反应的预测因子输入,以测试PD中的脑激素行为相关性。公共卫生相关性:这项研究对公共卫生很重要,因为围产期抑郁症(PD)的成本很高,不仅对母亲,而且对婴儿的未来发展和心理健康风险。然而,PD的神经生物学基础及其对母婴二分体的影响还没有很好的理解。通过识别区分围产期抑郁母亲的神经反应模式及其与表现出伤害婴儿的行为和神经内分泌失调方面的关系,我们将能够更好地描述谁处于风险中以及为什么,从而允许开发更精确和有效的治疗靶点,以减少疾病的传播。

项目成果

期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Mothers Who Were Neglected in Childhood Show Differences in Neural Response to Their Infant's Cry.
童年时期被忽视的母亲对婴儿哭声的神经反应存在差异。
  • DOI:
    10.1177/1077559516683503
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    5.1
  • 作者:
    Wright,DorianneB;Laurent,HeidemarieK;Ablow,JenniferC
  • 通讯作者:
    Ablow,JenniferC
Neural correlates of hypothalamic-pituitary-adrenal regulation of mothers with their infants.
  • DOI:
    10.1016/j.biopsych.2011.06.011
  • 发表时间:
    2011-11-01
  • 期刊:
  • 影响因子:
    10.6
  • 作者:
    Laurent, Heidemarie K;Stevens, Alexander;Ablow, Jennifer C
  • 通讯作者:
    Ablow, Jennifer C
Emotion Regulation in Parenthood.
  • DOI:
    10.1016/j.dr.2014.12.008
  • 发表时间:
    2015-06-01
  • 期刊:
  • 影响因子:
    6.6
  • 作者:
    Rutherford, Helena J. V.;Wallace, Norah S.;Laurent, Heidemarie K.;Mayes, Linda C.
  • 通讯作者:
    Mayes, Linda C.
A face a mother could love: depression-related maternal neural responses to infant emotion faces.
  • DOI:
    10.1080/17470919.2012.762039
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    2
  • 作者:
    Laurent HK;Ablow JC
  • 通讯作者:
    Ablow JC
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HEIDEMARIE KAISER LAURENT其他文献

HEIDEMARIE KAISER LAURENT的其他文献

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{{ truncateString('HEIDEMARIE KAISER LAURENT', 18)}}的其他基金

Maternal Depression Calibrates Infants' Neuroendocrine, Autonomic, and Inflammatory Stress Responsiveness
母亲抑郁症可调节婴儿的神经内分泌、自主神经和炎症应激反应
  • 批准号:
    10401874
  • 财政年份:
    2018
  • 资助金额:
    $ 5.12万
  • 项目类别:
Maternal Depression Calibrates Infants' Neuroendocrine, Autonomic, and Inflammatory Stress Responsiveness
母亲抑郁症可调节婴儿的神经内分泌、自主神经和炎症应激反应
  • 批准号:
    9754851
  • 财政年份:
    2018
  • 资助金额:
    $ 5.12万
  • 项目类别:
Maternal Depression Calibrates Infants' Neuroendocrine, Autonomic, and Inflammatory Stress Responsiveness
母亲抑郁症可调节婴儿的神经内分泌、自主神经和炎症应激反应
  • 批准号:
    9524011
  • 财政年份:
    2018
  • 资助金额:
    $ 5.12万
  • 项目类别:
Maternal Depression Calibrates Infants' Neuroendocrine, Autonomic, and Inflammatory Stress Responsiveness
母亲抑郁症可调节婴儿的神经内分泌、自主神经和炎症应激反应
  • 批准号:
    10531793
  • 财政年份:
    2018
  • 资助金额:
    $ 5.12万
  • 项目类别:
Mapping Neural Response to Infant Distress in Depressed New Mothers
绘制抑郁新妈妈对婴儿窘迫的神经反应
  • 批准号:
    7612335
  • 财政年份:
    2008
  • 资助金额:
    $ 5.12万
  • 项目类别:

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