Does the Neighborhood Environment Modify Genetic Risk for Cognitive Decline?

社区环境是否会改变认知能力下降的遗传风险?

基本信息

  • 批准号:
    8369883
  • 负责人:
  • 金额:
    $ 7.78万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-09-30 至 2013-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Dementia is a common and disabling brain disorder among older adults that has consequences for independence, functional decline, institutionalization, and mortality. Previous research has identified multiple biological, genetic, and behavioral factors that are associated with cognitive impairment and decline. For example, a relatively common polymorphism in the apolipoprotein E (ApoE) gene, the e4allele, is strongly associated with cognitive decline and is significantly higher among those with Alzheimer's disease compared to rest of the population. Recently, a parallel literature has looked beyond individual-level factors to consider the role of the social and built environment. Findings suggest that residence in socioeconomically advantaged neighborhoods may promote cognitive function and/or buffer cognitive decline in part through their greater density of physical resources (recreational centers, gyms, parks, walking paths) as well as social and institutional resources (libraries, bookstores, community centers, social clubs) that promote physical activity and facilitate mental stimulation. However, an interesting question remains as to whether there are specific sub-populations of older adults who may especially benefit from residence in resource-intensive neighborhoods by virtue of the fact that they are at higher risk for cognitive decline because they carry the e4 allele. We propose to conduct a secondary analysis of data from the Chicago Health and Aging Project, a prospective NIA-funded population based cohort study of older adults in the city of Chicago who were surveyed 5 times over a 16 year period (1993-2009). In addition to being a longitudinal study collecting genetic markers for dementia (APOE e4allele), the study also collected objectively measured, detailed environmental data (including the presence of parks, trees, libraries, churches, community centers). As such, the data provide an ideal opportunity to examine the possible role of neighborhood environments in modifying cognitive decline among older adults who are genetically at risk. PUBLIC HEALTH RELEVANCE: An estimated 5.4 million people in the U.S. over age 70 have cognitive impairment, with consequences for quality of life, functional decline, institutionalizatin, and mortality. Although people with severe impairment in cognition may be concentrated in institutions, the majority of older adults with cognitive impairment live in the community. The proposed research builds on earlier work demonstrating the cognitive benefits of living in resource intensive neighborhoods, by examining whether these benefits are particularly salient in attenuating cognitive decline among older adults who are genetically at risk.
描述(由申请人提供):痴呆症是老年人中常见的致残性脑部疾病,对独立性、功能下降、制度化和死亡率有影响。之前的研究已经发现了多种生物、基因、

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Philippa Clarke其他文献

Philippa Clarke的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Philippa Clarke', 18)}}的其他基金

A National Neighborhood Data Resource to Understand Inequities in the Health and Socioeconomic Impacts of COVID-19 in the United States
用于了解美国 COVID-19 健康和社会经济影响中的不平等现象的全国邻里数据资源
  • 批准号:
    10609939
  • 财政年份:
    2022
  • 资助金额:
    $ 7.78万
  • 项目类别:
Cognitive Resilience and Community Context: Examining the role of Neighborhood Built and Social Environments for Slowing the Progression of Dementia among older Americans
认知弹性和社区背景:研究社区建设和社会环境对减缓美国老年人痴呆症进展的作用
  • 批准号:
    9923497
  • 财政年份:
    2017
  • 资助金额:
    $ 7.78万
  • 项目类别:
Understanding the Role of the Built Environment for Mobility in Older Adults
了解建筑环境对老年人出行的作用
  • 批准号:
    8581483
  • 财政年份:
    2013
  • 资助金额:
    $ 7.78万
  • 项目类别:
Understanding the Role of the Built Environment for Mobility in Older Adults
了解建筑环境对老年人出行的作用
  • 批准号:
    8712308
  • 财政年份:
    2013
  • 资助金额:
    $ 7.78万
  • 项目类别:
Urban Built Environments and Trajectories of Disability Among Older Adults
城市建筑环境和老年人残疾轨迹
  • 批准号:
    7497113
  • 财政年份:
    2007
  • 资助金额:
    $ 7.78万
  • 项目类别:
Urban Built Environments and Trajectories of Disability Among Older Adults
城市建筑环境和老年人残疾轨迹
  • 批准号:
    7680996
  • 财政年份:
    2007
  • 资助金额:
    $ 7.78万
  • 项目类别:
Urban Built Environments and Trajectories of Disability Among Older Adults
城市建筑环境和老年人残疾轨迹
  • 批准号:
    7395209
  • 财政年份:
    2007
  • 资助金额:
    $ 7.78万
  • 项目类别:

相似国自然基金

靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
  • 批准号:
    JCZRQN202500010
  • 批准年份:
    2025
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
  • 批准号:
    2025JJ70209
  • 批准年份:
    2025
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
  • 批准号:
  • 批准年份:
    2024
  • 资助金额:
    0 万元
  • 项目类别:
    面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
  • 批准号:
    2023JJ50274
  • 批准年份:
    2023
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
  • 批准号:
  • 批准年份:
    2022
  • 资助金额:
    33 万元
  • 项目类别:
    地区科学基金项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
  • 批准号:
    n/a
  • 批准年份:
    2022
  • 资助金额:
    10.0 万元
  • 项目类别:
    省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
  • 批准号:
    81973577
  • 批准年份:
    2019
  • 资助金额:
    55.0 万元
  • 项目类别:
    面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
  • 批准号:
    81602908
  • 批准年份:
    2016
  • 资助金额:
    18.0 万元
  • 项目类别:
    青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
  • 批准号:
    81501928
  • 批准年份:
    2015
  • 资助金额:
    18.0 万元
  • 项目类别:
    青年科学基金项目

相似海外基金

The Phenomenon of Stem Cell Aging according to Methylation Estimates of Age After Hematopoietic Stem Cell Transplantation
根据造血干细胞移植后甲基化年龄估算干细胞衰老现象
  • 批准号:
    23K07844
  • 财政年份:
    2023
  • 资助金额:
    $ 7.78万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Analysis of Age-dependent Functional Changes in Skeletal Muscle CB1 Receptors by an in Vitro Model of Aging-related Muscle Atrophy
通过衰老相关性肌肉萎缩的体外模型分析骨骼肌 CB1 受体的年龄依赖性功能变化
  • 批准号:
    22KJ2960
  • 财政年份:
    2023
  • 资助金额:
    $ 7.78万
  • 项目类别:
    Grant-in-Aid for JSPS Fellows
Joint U.S.-Japan Measures for Aging and Dementia Derived from the Prevention of Age-Related and Noise-induced Hearing Loss
美日针对预防与年龄相关和噪声引起的听力损失而导致的老龄化和痴呆症联合措施
  • 批准号:
    23KK0156
  • 财政年份:
    2023
  • 资助金额:
    $ 7.78万
  • 项目类别:
    Fund for the Promotion of Joint International Research (International Collaborative Research)
The Effects of Muscle Fatigability on Gait Instability in Aging and Age-Related Falls Risk
肌肉疲劳对衰老步态不稳定性和年龄相关跌倒风险的影响
  • 批准号:
    10677409
  • 财政年份:
    2023
  • 资助金额:
    $ 7.78万
  • 项目类别:
Characterizing gut physiology by age, frailty, and sex: assessing the role of the aging gut in "inflamm-aging"
按年龄、虚弱和性别表征肠道生理学特征:评估衰老肠道在“炎症衰老”中的作用
  • 批准号:
    497927
  • 财政年份:
    2023
  • 资助金额:
    $ 7.78万
  • 项目类别:
Role of AGE/RAGEsignaling as a driver of pathological aging in the brain
AGE/RAGE信号传导作为大脑病理性衰老驱动因素的作用
  • 批准号:
    10836835
  • 财政年份:
    2023
  • 资助金额:
    $ 7.78万
  • 项目类别:
Deciphering the role of osteopontin in the aging eye and age-related macular degeneration
破译骨桥蛋白在眼睛老化和年龄相关性黄斑变性中的作用
  • 批准号:
    10679287
  • 财政年份:
    2023
  • 资助金额:
    $ 7.78万
  • 项目类别:
Targeting Age-Activated Proinflammatory Chemokine Signaling by CCL2/11 to Enhance Skeletal Muscle Regeneration in Aging
通过 CCL2/11 靶向年龄激活的促炎趋化因子信号传导以增强衰老过程中的骨骼肌再生
  • 批准号:
    478877
  • 财政年份:
    2023
  • 资助金额:
    $ 7.78万
  • 项目类别:
    Operating Grants
Elucidation of the protein kinase NLK-mediated aging mechanisms and treatment of age-related diseases
阐明蛋白激酶NLK介导的衰老机制及年龄相关疾病的治疗
  • 批准号:
    23K06378
  • 财政年份:
    2023
  • 资助金额:
    $ 7.78万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Underlying mechanisms of age-related changes in ingestive behaviors: From the perspective of the aging brain and deterioration of the gustatory system.
与年龄相关的摄入行为变化的潜在机制:从大脑老化和味觉系统退化的角度来看。
  • 批准号:
    23K10845
  • 财政年份:
    2023
  • 资助金额:
    $ 7.78万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了