2012 CSHL Neurodegenerative Diseases Conference

描述（由申请人提供）：本提案寻求对将于2012年11月28日至12月1日在冷泉港实验室（CSHL）举行的神经退行性疾病两年一度会议的支持。这次会议汇集了研究神经退行性疾病（如阿尔茨海默病，帕金森病和肌萎缩侧索硬化症）的基本和转化方面的科学家。对于许多这样的疾病，疾病过程中的步骤仍然不清楚，因此尚未确定生物标志物。对于其他疾病，现有的治疗方法主要是为了缓解症状，而不是解决潜在的退行性过程。因此，需要转化研究来开发和验证新的诊断策略以及可能阻止或阻止疾病进展的新疗法，而不仅仅是缓解症状。该会议将通过提供一个论坛，使来自不同实验室和机构的科学家，无论是学术界还是工业界，都可以相互交流，从而促进神经退行性疾病的知识。它将包括朊病毒样神经变性，风险因素和共病，RNA代谢，神经胶质生物学，免疫和小分子治疗，以及基因失活策略的会议。对于利用新疗法治疗神经退行性疾病的人类研究来说，至关重要的是，研究这些治疗方法不同方面的科学家必须定期在CSHL这样的环境中交流数据和想法。2012年CSHL神经退行性疾病会议将在之前CSHL会议成功的基础上，召集国际科学家聚会，讨论该领域的新发展，并促进创新研究合作，所有这些都将最终加快发现的步伐。

DESCRIPTION (provided by applicant): This proposal seeks support for the biennial conference on Neurodegenerative Diseases, which will take place November 28-December 1, 2012, at Cold Spring Harbor Laboratory (CSHL). This meeting brings together scientists who investigate both basic and translational aspects of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. For many such disorders, steps in the disease processes remain unclear and thus biomarkers have not yet been identified. For other disorders, existing treatments are designed primarily to provide relief from symptoms, and do not address the underlying degenerative processes. Translational research is therefore needed to develop and validate novel diagnostic strategies as well as new therapeutics that might halt or stem disease progression, rather than simply alleviate symptoms. The conference will advance knowledge in neurodegeneration by providing a forum where scientists from distinct laboratories and institutions, both academic and from industry, can interact with each other. It will include sessions on prion-like neurodegeneration, risk factors an co-morbidities, RNA metabolism, glial biology, immune and small-molecule therapies, and gene inactivation strategies. For human studies utilizing new treatments for neurodegeneration to be informative, it is crucial that scientists who research different aspects of those treatments meet regularly in a setting like CSHL to exchange data and ideas. The 2012 CSHL meeting on Neurodegenerative Diseases will build on the successes of prior CSHL meetings to assemble an international gathering of scientists, discuss new developments in the field, and catalyze innovative research collaborations, all of which will ultimately accelerate the pace of discovery.