CSHL 2023 Conference on Systems Immunology

冷泉港系统免疫学会议 冷泉港，纽约州 2023年4月18日至22日 摘要 免疫反应是由不同的细胞和分子在空间和时间上运作而协调的， 例如，在不同的尺度上，极其复杂的淋巴细胞受体库可以区分 在自身和非自身抗原之间，随后触发动态的细胞-细胞相互作用，最终导致 产生效应子功能，包括抗体和杀死病毒感染的细胞。关键的发现 由实验免疫学家研究单个分子，细胞及其相互作用。由于 这些不同的免疫成分之间相互作用的复杂性， 与免疫调节和反应协调相关的问题仍未得到解决。要取得进一步进展， 集成高维多组学方法，以及计算和定量建模来分析 在系统的各种尺度上的细胞行为。这些属性不能被分析或直观的， 常规实验。很明显，实验免疫学家和 计算和系统生物学家需要推进我们对免疫系统的系统级理解。 应答这次会议是两年一次的系列会议中的第三次， 在快速发展和扩大的系统免疫学领域的想法和技术。基础上 2019年和2021年在CSHL举行的前两次会议的成功，已经建立了这个经常性会议， 这是一个领先的论坛，可以维持一个高度互动的系统免疫学家社区。 拟议的会议将重点关注免疫学和系统界面的最新进展， 计算生物学，包括工程免疫颗粒和细胞的合理设计和应用。 会议将突出多维实验平台和计算方法， 用于分析控制离散效应器应答的单个免疫细胞的信号传导和基因组状态 以时空的方式。在不同时间点整合免疫原性、致耐受性或病理生理学应答 将探索小鼠和人类的细胞、组织和器官的规模水平。共享和独特的设计 免疫系统的发展，功能和进化的基础原则将从 分析的观点。关于人类系统免疫学的会议将包括以下方面的高维分析： 对SARS-CoV-2感染以及COVID-19疫苗的免疫反应。会议将培养和 培养一个系统免疫学家社区，将高维分析和成像与 计算和定量分析，以加深对免疫系统状态和反应的理解。 一组杰出的特邀讲者和选定的讲者将作口头报告 提交的摘要。选定的演讲者将主要包括研究生，博士后研究员和 初级教师旨在最大限度地纳入年轻的研究人员。特别重要的是两张海报 在这些会议上，许多与会者可以在有利于非正式讨论的气氛中介绍他们的工作。 会议将是中等规模，我们预计约250-300人参加的人，大多数 其中将展示海报或演讲，另外还有150-200名虚拟观众， 扩大了那些本来无法参与的人的参与机会。预计演讲者将出席 亲自参加，并根据具体情况给予豁免。混合格式将允许扩大访问， 由于旅行/签证限制、家庭义务或其他原因而无法参加的科学家 经济负担。青年研究人员、少数民族和女科学家的参与将得到大力支持。 鼓励。该提议包括为支持早期职业调查员参与工作而请拨的资金。

Cold Spring Harbor Conference on Systems Immunology Cold Spring Harbor, NY April 18 – 22, 2023 ABSTRACT Immune responses are orchestrated by diverse cells and molecules operating over space and time and across different scales, for example, extremely complex repertoires of lymphocyte receptors can discriminate between self and non-self antigens and subsequently trigger dynamic cell-cell interactions culminating in the production of effector functions including antibodies and killing of virus infected cells. Critical discoveries have been made by experimental immunologists studying individual molecules, cells, and their interactions. Due to the complexity of the interactions among these diverse immune components, many fundamental issues associated with immune regulation and response orchestration remain unresolved. Further progress requires an integration of high-dimensional multi-omic approaches, and computational and quantitative modeling to analyze cellular behaviors at various scales of the system. These properties cannot be analyzed or intuited by conventional experiments. It is clear that effective collaborations between experimental immunologists and computational and systems biologists are required to advance our systems-level understanding of immune responses. This meeting is the third in a biennial series that catalyzing a cross-disciplinary exchange of new ideas and technologies in the rapidly evolving and expanding field of systems immunology. Building on the successes of the first two meetings held at CSHL in 2019 and 2021, have established this recurring meeting as the leading forum that can sustain a highly interactive community of Systems Immunologists. The proposed meeting will focus on recent advances at the interface of immunology and systems and computational biology, including rational design and applications of engineered immune particles and cells. Sessions will highlight multi-dimensional experimental platforms and computational approaches that are being used to analyze signaling and genomic states of individual immune cells that control discrete effector responses in a spatiotemporal manner. Integration of immunogenic, tolerogenic or pathophysiologic responses at different levels of scale – cellular, tissues and organs in mice and humans will be explored. Shared and unique design principles that underlie the development, functioning and evolution of the immune system will be discussed from an analytic standpoint. The session on Human Systems Immunology will include high-dimensional analyses of immune responses to SARS-CoV-2 infection as well as to COVID-19 vaccines. The meeting will nurture and foster a community of systems immunologists that are coupling high-dimensional profiling and imaging with computational and quantitative analyses to deepen the understanding of immune system states and responses. Oral presentations will be given by a group of distinguished invited speakers as well as speakers selected from submitted abstracts. Selected speakers will include primarily graduate students, postdoctoral fellows and junior faculty aiming for maximal inclusion of young investigators. Of special importance are the two poster sessions, where many participants can present their work in an atmosphere conducive to informal discussion. The meeting will be of moderate size and we expect about 250-300 people to participate in person, the majority of whom will be presenting a poster or talk, with an additional virtual audience of 150-200 layered over to provide broadened access to those who would otherwise be unable to participate. Presenters will be expected to attend in-person with exemptions granted on a case-by-case basis. The hybrid format will allow broadened access to scientists who would otherwise be unable to attend because of travel/visa restrictions, family obligations or financial burden. The participation of young investigators, minority, and women scientists will be strongly encouraged. This proposal includes requested funding to support the participation of early career Investigators.