CSHL 2022 Glia in Health & Disease Conference

2022年冷泉港实验室会议 胶质细胞在健康和疾病中的作用 摘要 关于健康与疾病中胶质细胞的拟议会议将在冷泉港举行 实验室从2022年7月21日至25日。本次会议的目标是为以下方面提供一个积极的论坛： 在神经胶质生物学和神经元-神经胶质相互作用的快速发展领域的成果交流。 神经胶质细胞是一组非神经元细胞，是神经系统的重要组成部分 发育、电路功能和神经系统疾病。这些细胞执行许多重要的 作用，如塑造发育中的电路，调节神经递质之间的信号传导， 神经元，为神经元和其他神经胶质细胞提供代谢支持，支持快速和 动作电位的有效传播，调节血管发育和血流，以及 调节疾病中的炎症级联反应。随着基因工具的进步， 特别是针对神经胶质细胞，我们现在正在获得更深入的机械理解， 其他神经胶质细胞功能的健康和疾病。这包括一个新的认识，胶质细胞积极 调节神经回路功能、可塑性和健康、稳态条件下的行为。 我们现在也意识到这些功能在疾病中是如何出错的， 功能障碍、慢性炎症和神经元及其突触连接的破坏。 也有明确的迹象表明，胶质细胞可能不仅对患病的神经元作出反应， 疾病，但它们是潜在病因的一部分。例如，许多基因突变 与神经退行性疾病有关，如阿尔茨海默病和多发性硬化症（MS）， 都存在于富含神经胶质的基因中。进一步的基因操纵研究开始揭示 这些突变改变神经胶质细胞功能并导致疾病。增加了 疾病，神经胶质细胞也可以是有益的，并促进再生和组织修复， 功能如提供代谢支持、吞噬碎片和形成保护性神经胶质 伤疤本次会议将突出神经胶质细胞生物学的最新进展， 研究无脊椎动物和脊椎动物模型系统，以及人体组织和细胞，使用 最先进的遗传学、分子生物学、生物化学、生理学和成像技术 技术.利用前八次非常成功的会议的目标和形式， 指导，我们计划：1）召集一次从事神经胶质细胞研究的科学家国际会议， 生物学和神经胶质细胞的相互作用; 2）讨论新的和令人兴奋的发展领域， 根据科学价值从公开提交的摘要中选择演讲; 3）提供一个 不同背景的年轻科学家有机会展示他们的数据， 与更成熟的研究人员进行科学讨论; 4）促进合作 互动，以加快发现的步伐，并确定新的方法，以更好地 了解神经系统功能，并最终靶向神经胶质细胞治疗神经系统疾病 疾病

2022 Cold Spring Harbor Laboratory Conference GLIA IN HEALTH & DISEASE Abstract The proposed meeting on Glia in Health & Disease will be held at Cold Spring Harbor Laboratory from July 21 – 25, 2022. The goal of this conference is to provide an active forum for exchange of results in the rapidly advancing fields of glial biology and neuron-glia interactions. Glial cells comprise a diverse group of non-neuronal cells that are essential for nervous system development, circuit function, and neurological disease. These cells perform many important roles, such as sculpting developing circuits, regulating neurotransmitter signaling between neurons, providing metabolic support to neurons and other glial cells, supporting the fast and efficient propagation of action potentials, modulating vascular development and blood flow, and regulating inflammatory cascades in disease. With the advancement of genetic tools to specifically target glia, we are now gaining a deeper mechanistic understanding of these and other glial cell functions in health and disease. This includes a new realization that glia actively modulate neural circuit function, plasticity, and behavior under healthy, steady-state conditions. We are also now appreciating how these functions go awry in disease, leading to circuit dysfunction, chronic inflammation, and destruction of neurons and their synaptic connections. There are also clear indications that glia may not only react to diseased neurons to propagate disease, but they are a part of the underlying etiology. For example, many gene mutations linked to neurodegenerative diseases, such as Alzheimer's disease and multiple sclerosis (MS), are in genes enriched in glia. Further genetic manipulation studies are beginning to reveal how these mutations alter glial cell function and contribute to disease. Adding to the complexity in disease, glia can also be beneficial and promote regeneration and tissue repair by performing functions such as providing metabolic support, engulfing debris, and forming protective glial scars. This meeting will highlight the latest developments in glial cell biology obtained through studies of invertebrate and vertebrate model systems, as well as human tissue and cells, using the most up-to-date genetics, molecular biology, biochemistry, physiology, and imaging technologies. Using the goals and format of the eight prior extremely successful meetings as a guide, we plan to: 1) assemble an international meeting of scientists engaged in studies of glial biology and neuron-glia interactions; 2) discuss new and exciting developments in the field by selecting talks from openly submitted abstracts on the basis of scientific merit; 3) provide an opportunity for junior scientists of diverse backgrounds to present their data and engage in scientific discourse with more established investigators; and 4) promote collaborative interactions to accelerate the pace of discovery and identify novel approaches to better understand nervous system function and, ultimately, target glial cells to treat neurological diseases.