CSHL 2022 Glia in Health & Disease Conference

CSHL 2022 神经胶质细胞健康

• 批准号: 10387663
• 负责人: DAVID J. STEWART
• 金额: $ 2.3万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10387663
• 关键词: Action Potentials; Advanced Development; Aging; Alzheimer' s Disease; Area; Axon; Behavior; Biochemistry; Biological Models; Biology; Blood Vessels; Blood flow; Brain; Cell physiology; Cells; Cellular biology; Chronic; Cicatrix; Communities; Data; Development; Disease; Ensure; Environment; Etiology; Faculty; Fostering; Functional disorder; Future; Gene Mutation; Genes; Genetic; Goals; Health; Human; Image; Imaging technology; Industry; Inflammation; Inflammatory; Injury; International; Invertebrates; Laboratories; Lead; Length of Stay; Link; Metabolic; Methodology; Minority; Molecular; Molecular Biology; Molecular Genetics; Multiple Sclerosis; Mutation; Natural regeneration; Nerve Regeneration; Nervous System Physiology; Neurodegenerative Disorders; Neuroglia; Neurons; Neurophysiology - biologic function; Neurotransmitters; Oral; Participant; Physiology; Play; Postdoctoral Fellow; Research; Research Institute; Research Personnel; Role; Schedule; Scientist; Series; Signal Transduction; Synapses; Synaptic plasticity; System; Woman; Work; base; genetic manipulation; graduate student; human disease; human tissue; imaging approach; interest; laboratory facility; meetings; member; nervous system development; nervous system disorder; neural circuit; new therapeutic target; notch protein; novel strategies; novel therapeutic intervention; novel therapeutics; posters; relating to nervous system; repaired; success; symposium; therapeutic target; tissue repair; tool; unpublished works; virtual

2022 Cold Spring Harbor Laboratory Conference GLIA IN HEALTH & DISEASE Abstract The proposed meeting on Glia in Health & Disease will be held at Cold Spring Harbor Laboratory from July 21 – 25, 2022. The goal of this conference is to provide an active forum for exchange of results in the rapidly advancing fields of glial biology and neuron-glia interactions. Glial cells comprise a diverse group of non-neuronal cells that are essential for nervous system development, circuit function, and neurological disease. These cells perform many important roles, such as sculpting developing circuits, regulating neurotransmitter signaling between neurons, providing metabolic support to neurons and other glial cells, supporting the fast and efficient propagation of action potentials, modulating vascular development and blood flow, and regulating inflammatory cascades in disease. With the advancement of genetic tools to specifically target glia, we are now gaining a deeper mechanistic understanding of these and other glial cell functions in health and disease. This includes a new realization that glia actively modulate neural circuit function, plasticity, and behavior under healthy, steady-state conditions. We are also now appreciating how these functions go awry in disease, leading to circuit dysfunction, chronic inflammation, and destruction of neurons and their synaptic connections. There are also clear indications that glia may not only react to diseased neurons to propagate disease, but they are a part of the underlying etiology. For example, many gene mutations linked to neurodegenerative diseases, such as Alzheimer's disease and multiple sclerosis (MS), are in genes enriched in glia. Further genetic manipulation studies are beginning to reveal how these mutations alter glial cell function and contribute to disease. Adding to the complexity in disease, glia can also be beneficial and promote regeneration and tissue repair by performing functions such as providing metabolic support, engulfing debris, and forming protective glial scars. This meeting will highlight the latest developments in glial cell biology obtained through studies of invertebrate and vertebrate model systems, as well as human tissue and cells, using the most up-to-date genetics, molecular biology, biochemistry, physiology, and imaging technologies. Using the goals and format of the eight prior extremely successful meetings as a guide, we plan to: 1) assemble an international meeting of scientists engaged in studies of glial biology and neuron-glia interactions; 2) discuss new and exciting developments in the field by selecting talks from openly submitted abstracts on the basis of scientific merit; 3) provide an opportunity for junior scientists of diverse backgrounds to present their data and engage in scientific discourse with more established investigators; and 4) promote collaborative interactions to accelerate the pace of discovery and identify novel approaches to better understand nervous system function and, ultimately, target glial cells to treat neurological diseases.

2022年冷泉港实验室会议 健康与疾病的神经胶质 抽象的 拟议的有关健康与疾病神经胶质的会议将在冷春港举行 从2022年7月21日至25日的实验室。这次会议的目标是为 在神经胶质生物学和神经胶质相互作用的迅速发展领域的结果交换。 神经胶质细胞包括一组对神经系统必不可少的非神经元细胞的潜水 发育，电路功能和神经疾病。这些细胞执行许多重要 角色，例如雕刻开发电路，调节神经递质信号传导 神经元，为神经元和其他神经胶质细胞提供代谢支持，支持快速和 有效地传播动作电位，调节血管发育和血流，以及 调节疾病中的炎症级联反应。随着遗传工具的发展 特别是针对神经胶质的，我们现在正在对它们进行更深入的机械理解，并且 其他神经胶质细胞在健康和疾病中起作用。这包括一个新的认识，即神经胶质积极 调节在健康，稳态条件下的神经回路功能，可塑性和行为。 我们现在也很欣赏这些功能如何在疾病中出现问题，导致电路 神经元及其突触连接的功能障碍，慢性炎症和破坏。 还有清楚的迹象表明，神经胶质不仅可能对脱离神经元反应以传播 疾病，但它们是基本病因的一部分。例如，许多基因突变 与神经退行性疾病有关，例如阿尔茨海默氏病和多发性硬化症（MS）， 在富含神经胶质的基因中。进一步的遗传操纵研究开始揭示 这些突变改变了神经胶质细胞功能并有助于疾病。增加复杂性 疾病，神经胶质也可能是有益的，并通过执行来促进再生和组织修复 诸如提供代谢支持，吞噬碎片和形成保护性神经胶质等功能 疤痕。这次会议将强调通过 使用无脊椎动物和脊椎动物模型系统以及人体组织和细胞的研究，使用 最新的遗传学，分子生物学，生物化学，生理学和成像 技术。使用八个先前的极其成功的会议的目标和格式作为 指南，我们计划：1）组建一场从事神经胶质研究的科学家会议 生物学和神经胶质相互作用； 2）讨论该领域的新事态发展 根据科学功绩从公开提交的摘要中选择谈判； 3）提供一个 潜水员背景的初级科学家提供数据并参与的机会 与更既定的研究人员的科学论述； 4）促进合作 相互作用以加速发现空间并确定新颖的方法以更好 了解神经系统功能，并最终靶向神经胶质细胞以治疗神经系统 疾病。