Inflammasome function in protection against infectious disease and autoimmunity

炎症小体在预防传染病和自身免疫方面的功能

• 批准号: nhmrc : 1059729
• 负责人: A/Pr Katryn Stacey
• 金额: $ 42.08万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/inflammasome-function-protection-disease-autoimmunity/454778
• 关键词: Inflammasome; function; protection; against; infectious

Inflammation, characterised by swelling, heat, pain and redness, is a normal response to injury and infection. Many human diseases such as gout, athersclerosis, diabetes and Alzheimer’s disease involve some inflammation, mediated through a common pathway termed the inflammasome. This project will investigate the proteins involved in this pathway and how they interact in their normal role of combatting infections, as well as a possible defect in this pathway in autoimmune patients.

炎症，其特征是肿胀，发热，疼痛和发红，是对损伤和感染的正常反应。许多人类疾病如痛风、动脉粥样硬化、糖尿病和阿尔茨海默病涉及一些炎症，通过称为炎性体的共同途径介导。该项目将研究参与这一途径的蛋白质，以及它们在对抗感染的正常作用中如何相互作用，以及自身免疫性患者中这一途径可能存在的缺陷。