Dengue virus NS1 protein as a mediator of pathology

登革热病毒 NS1 蛋白作为病理介质

• 批准号: nhmrc : GNT1109738
• 负责人: A/Pr Katryn Stacey
• 金额: $ 62.2万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dengue-virus-ns1-mediator-pathology/1346694
• 关键词: Dengue; virus; NS1; protein; mediator

Dengue virus is an increasing problem in the tropical world, with estimated infection of more than 300 million people annually. Severe dengue disease can cause life-threatening bleeding and shock. Our project investigates the basis for the pathology of the disease. We have found that a viral protein termed NS1 binds to a receptor on immune cells and leads to production of inflammatory proteins which can promote vessel leakage. We will investigate drugs blocking this, in a disease model.

登革热病毒在热带世界是一个日益严重的问题，估计每年有3亿多人感染。严重的登革热可导致危及生命的出血和休克。我们的项目研究了这种疾病的病理学基础。我们发现一种名为NS1的病毒蛋白与免疫细胞上的受体结合，导致炎症蛋白的产生，从而促进血管渗漏。我们将在疾病模型中研究阻断这种作用的药物。