Response of the body to microbes, and development of autoimmunity

身体对微生物的反应以及自身免疫的发展

• 批准号: nhmrc : GNT1059729
• 负责人: A/Pr Katryn Stacey
• 金额: $ 60.14万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/response-body-microbes-development-autoimmunity/1344704
• 关键词: Response; body; microbes; development; autoimmunity

Inflammation, characterised by swelling, heat, pain and redness, is a normal response to injury and infection. Many human diseases such as gout, athersclerosis, diabetes and Alzheimer’s disease involve some inflammation, mediated through a common pathway termed the inflammasome. This project will investigate the proteins involved in this pathway and how they interact in their normal role of combatting infections, as well as a possible defect in this pathway in autoimmune patients.

炎症，其特征是肿胀，发热，疼痛和发红，是对损伤和感染的正常反应。许多人类疾病如痛风、动脉粥样硬化、糖尿病和阿尔茨海默病涉及一些炎症，通过称为炎性体的共同途径介导。该项目将研究参与这一途径的蛋白质，以及它们在对抗感染的正常作用中如何相互作用，以及自身免疫性患者中这一途径可能存在的缺陷。